2024-03-28T22:22:26Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1831882020-10-19T07:25:59Zcom_10261_54com_10261_1col_10261_307
2019-06-03T12:55:29Z
urn:hdl:10261/183188
The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia
Mecha, Miriam
Yanguas-Casás, Natalia
Feliú, Ana
Mestre, Leyre
Carrillo-Salinas, F. J.
Azcoitia, I.
Yong, Y. W.
Guaza, Carmen
Ministerio de Economía y Competitividad (España)
Red Española de Esclerosis Múltiple
Instituto de Salud Carlos III
Remyelination
Endocannabinoids
Microglia
Phagocytosis
TMEV
Remyelination is an endogenous process by which functional recovery of damaged neurons is achieved by reinstating the myelin sheath around axons. Remyelination has been documented in multiple sclerosis (MS) lesions and experimental models, although it is often incomplete or fails to affect the integrity of the axon, thereby leading to progressive disability. Microglia play a crucial role in the clearance of the myelin debris produced by demyelination and in inflammation-dependent OPC activation, two processes necessary for remyelination to occur. We show here that following corpus callosum demyelination in the TMEV-IDD viral murine model of MS, there is spontaneous and partial remyelination that involves a temporal discordance between OPC mobilization and microglia activation. Pharmacological treatment with the endocannabinoid 2-AG enhances the clearance of myelin debris by microglia and OPC differentiation, resulting in complete remyelination and a thickening of the myelin sheath. These results highlight the importance of targeting microglia during the repair processes in order to enhance remyelination.
2019-06-03T12:55:29Z
2019-06-03T12:55:29Z
2019-03
artículo
Brain, Behavior, and Immunity 77: 110-126 (2019)
0889-1591
http://hdl.handle.net/10261/183188
10.1016/j.bbi.2018.12.013
1090-2139
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100007747
eng
Publisher's version
https://doi.org/10.1016/j.bbi.2018.12.013
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-42784-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-76449-R
https://creativecommons.org/licenses/by-nc-nd/4.0/
openAccess
Elsevier