2024-03-28T22:57:32Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1770122020-07-16T11:16:34Zcom_10261_5063com_10261_5col_10261_5066
2019-03-01T09:48:15Z
urn:hdl:10261/177012
NLCs as a potential carrier system for transdermal delivery of forskolin
Lasoń, Elwira
Solans, Conxita
Llinàs, Meritxell
Ogonowski, Jan
Ministerio de Economía y Competitividad (España)
Foskolin
Nanostructured lipid carrier
NLC
Skin permeation
Lipids
Nanoparticles
Nanostructured lipid carriers (NLC) composed of the substances generally recognized as safe (GRAS) were obtained by using a hot high-pressure homogenization technique (HPH). The influence of the number of homogenization cycles and concentration of a decyl glucoside surfactant on the NLC properties were studied. The system's stability was assessed by macroscopic observation, light backscattering and zeta potential measurements. NLC particle size was measured using dynamic light scattering (DLS). The kinetically stable formulations were loaded with forskolin and selected for in vitro drug permeation study using the Franz cell method. Concentration of forskolin in the receptor solution (i.e. ethanol/ PBS mixture) was analyzed with high performance liquid chromatography (HPLC) with UV detection. The obtained results have shown that NLC formulations could be used as effective carriers for forskolin permeation through the skin. © by Pawel Pomorski and Polish Biochemical Society 2015.
2019-03-01T09:48:15Z
2019-03-01T09:48:15Z
2018-09-15
artículo
Acta Biochimica Polonica
http://hdl.handle.net/10261/177012
10.18388/abp.2018_2554
http://dx.doi.org/10.13039/501100003329
eng
Publisher's version
https://doi.org/10.18388/abp.2018_2554
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ 2011-29336-CO3-01
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ 2011-29336-CO3-03
openAccess
Polish Biochemical Society