2024-03-29T01:21:49Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1684772020-12-13T09:18:03Zcom_10261_112com_10261_1col_10261_365
2018-08-09T09:23:59Z
urn:hdl:10261/168477
Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; The American Academy of Allergy, Asthma & Immunology; And the European Academy of Allergology and Clinical Immunology
Hartmann, Karin
Escribano, Luis
Grattan, Clive
Brockow, Knut
Carter, Melody C.
Álvarez-Twose, Iván
Matito, Almudena
Broesby-Olsen, Sigurd
Siebenhaar, Frank
Lange, Magdalena
Niedoszytko, Marek
Castells, Mariana
Oude Elberink, Joanna N. G.
Bonadonna, Patrizia
Zanotti, Roberta
Hornick, Jason L.
Torrelo, Antonio
Grabbe, Jürgen
Rabenhorst, Anja
Nedoszytko, Boguslaw
Butterfield, Joseph H.
Gotlib, Jason
Reiter, Andreas
Radia, Deepti
Hermine, Olivier
Sotlar, Karl
George, Tracy I.
Kristensen, Thomas K.
Kluin-Nelemans, Hanneke C.
Yavuz, Selim
Hägglund, Hans
Sperr, Wolfgang R.
Schwartz, Lawrence B.
Triggiani, Massimo
Maurer, Marcus
Nilsson, Gunnar
Horny, Hans-Peter
Arock, Michel
Orfao, Alberto
Metcalfe, Dean D.
Akin, Cem
Valent, Peter
Austrian Science Fund
European Academy of Allergy and Clinical Immunology
German Research Foundation
National Institute of Allergy and Infectious Diseases (US)
Mast cell
Urticaria pigmentosa
Standardization
Classification
Cutaneous mastocytosis
Diagnostic criteria
Mastocytosis
Cutaneous lesions in patients with mastocytosis are highly heterogeneous and encompass localized and disseminated forms. Although a classification and criteria for cutaneous mastocytosis (CM) have been proposed, there remains a need to better define subforms of cutaneous manifestations in patients with mastocytosis. To address this unmet need, an international task force involving experts from different organizations (including the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology) met several times between 2010 and 2014 to discuss the classification and criteria for diagnosis of cutaneous manifestations in patients with mastocytosis. This article provides the major outcomes of these meetings and a proposal for a revised definition and criteria. In particular, we recommend that the typical maculopapular cutaneous lesions (urticaria pigmentosa) should be subdivided into 2 variants, namely a monomorphic variant with small maculopapular lesions, which is typically seen in adult patients, and a polymorphic variant with larger lesions of variable size and shape, which is typically seen in pediatric patients. Clinical observations suggest that the monomorphic variant, if it develops in children, often persists into adulthood, whereas the polymorphic variant may resolve around puberty. This delineation might have important prognostic implications, and its implementation in diagnostic algorithms and future mastocytosis classifications is recommended. Refinements are also suggested for the diagnostic criteria of CM, removal of telangiectasia macularis eruptiva perstans from the current classification of CM, and removal of the adjunct solitary from the term solitary mastocytoma.
2018-08-09T09:23:59Z
2018-08-09T09:23:59Z
2016
2018-08-09T09:24:00Z
artículo
Journal of Allergy and Clinical Immunology 137(1): 35-45 (2016)
http://hdl.handle.net/10261/168477
10.1016/j.jaci.2015.08.034
http://dx.doi.org/10.13039/501100002428
http://dx.doi.org/10.13039/501100001659
http://dx.doi.org/10.13039/100000060
http://dx.doi.org/10.13039/501100011824
http://dx.doi.org/10.13039/100006492
26476479
eng
Sí
closedAccess
Elsevier
American College of Allergy, Asthma & Immunology