2024-03-28T10:40:33Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1564122017-12-18T13:59:22Zcom_10261_52707com_10261_5col_10261_52719
2017-10-18T11:22:57Z
urn:hdl:10261/156412
Multicomponent reactions in the synthesis of target molecules
Radtke, Lea
Marqués-López, Eugenia
Herrera, Raquel P.
Dihydropyrimidine
Spiro compound
Fused polyheterocycle
Asymmetric catalysis
Indole
Heterocycle
Target molecule
Natural product
Multicomponent reaction
Drug discovery
Multicomponent reactions are a powerful tool in the synthesis of complex target molecules because multiple bonds are effectively built up in one step from relatively simple building blocks. They introduce molecular diversity in only one step and do so in a highly efficient and convergent manner. Heterocycles are structural motifs that are often found in bioactive molecules or drugs, therefore the high yielding and fewer steps synthesis of these compounds is of great interest for Medicinal Chemistry. Here, we will discuss some multicomponent strategies to synthesize heterocycles like indoles, pyrroles, spiro-type polyheterocycles, fused polyheterocycles, dihydropyrimidines, thiazines, as well as amino acids.
2017-10-18T11:22:57Z
2017-10-18T11:22:57Z
2015
2017-10-18T11:22:57Z
capítulo de libro
Multicomponent Reactions: Concepts and Applications for Design and Synthesis (Cap.6): 198-246 (2015)
http://hdl.handle.net/10261/156412
10.1002/9781118863992.ch6
eng
Sí
closedAccess
John Wiley & Sons