2024-03-29T15:30:09Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1511292017-12-18T14:14:55Zcom_10261_22com_10261_1col_10261_275
2017-06-09T09:35:22Z
urn:hdl:10261/151129
Colon cancer-associated fibroblast establishment and culture growth
Herrera, Mercedes
Larriba, María Jesús
Ferrer-Mayorga, Gemma
García de Herreros, Antonio
Bonilla, Félix
Baulida, Josep
Peña, Cristina
European Commission
Comunidad de Madrid
Fundación Banco Santander
Ministerio de Economía y Competitividad (España)
Instituto de Salud Carlos III
Fundación Científica Asociación Española Contra el Cáncer
Cancer-associated fibroblasts (CAFs) are one of the major players in tumor-stroma
crosstalk. Findings in experimental studies suggest important roles for CAFs in regulation of tumor growth, metastasis and drug response (Hanahan and Coussens, 2012). Furthermore, their clinical relevance is supported by new findings from tumor analyses, demonstrating the prognostic and response-predictive significance of CAF-derived markers or gene signatures (Berdiel-hacer et al., 2014; Finak et al., 2008; Navab et al., 2011; Paulsson and Micke, 2014). CAFs are a heterogeneous pool of cell subsets with distinct functions which needs to be better defined by their marker expressions. The development of a methodology for the establishment of fibroblast primary cultures derived from human colon tumors allowed us to characterize their
functional and molecular properties (Herrera et al., 2013). In addition, the different molecular mechanisms through which CAFs affect tumor growth and metastasis are still to be clarified. Therefore, functional and molecular characterization of the cancer-associated fibroblasts is essential to fully understand their role in tumor progression.
2017-06-09T09:35:22Z
2017-06-09T09:35:22Z
2016
2017-06-09T09:35:22Z
artículo
Bio-protocol 6(7): e1773 (2016)
http://hdl.handle.net/10261/151129
10.21769/BioProtoc.1773
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/100008049
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100002704
http://dx.doi.org/10.13039/100012818
eng
Publisher's version
https://doi.org/10.21769/BioProtoc.1773
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-48849-C2-1-R
S2010/BMD-2344/Colomics2
openAccess
Bio-protocol LLC