2024-03-28T20:18:21Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1360862018-10-03T09:40:38Zcom_10261_22com_10261_1col_10261_275
2016-08-30T10:40:54Z
urn:hdl:10261/136086
Long-term dietary folate deficiency accelerates progressive hearing loss on CBA/Ca mice
Martínez-Vega, Raquel
Murillo-Cuesta, Silvia
Partearroyo, Teresa
Varela-Moreiras, Gregorio
Varela-Nieto, Isabel
Pajares, María A.
Ministerio de Economía y Competitividad (España)
European Commission
Consejo Superior de Investigaciones Científicas (España)
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Dietary folic acid deficiency induced early hearing loss in C57BL/6J mice after two-months, corroborating the epidemiological association previously described between vitamin deficiency and this sensory impairment. However, this strain is prone to early hearing loss, and hence we decided to analyze whether the effects exerted by folate deprivation follow the same pattern in a mouse strain such as CBA/Ca, which is resistant to hearing impairment. Here, we show results of a long-term study on hearing carried out on CBA/Ca mice subjected to dietary folate deprivation. Systemic changes included decreased serum folate levels, hyperhomocysteinemia and signs of anemia in the group fed the folate-deficient diet. Initial signs of hearing loss were detected in this strain after 8-months of vitamin deficiency, and correlated with histological damage in the cochleae. In conclusion, the data presented reinforce the importance of adequate folic acid levels for the auditory system and suggest that the impact of dietary deficiencies may depend on the genetic background.
2016-08-30T10:40:54Z
2016-08-30T10:40:54Z
2016
artículo
Frontiers in Aging Neuroscience 8: 209 (2016)
http://hdl.handle.net/10261/136086
10.3389/fnagi.2016.00209
1663-4365
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003339
27630560
eng
Publisher's version
http://dx.doi.org/10.3389/fnagi.2016.00209
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-53979-R
info:eu-repo/grantAgreement/EC/FP7/304900
info:eu-repo/grantAgreement/EC/FP7/612261
http://creativecommons.org/licenses/by/4.0/
openAccess
Frontiers Media