2024-03-29T09:38:06Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1239342018-08-13T10:48:47Zcom_10261_22com_10261_1col_10261_275
2015-10-27T12:43:31Z
urn:hdl:10261/123934
Estrogens regulate the hepatic effects of growth hormone, a hormonal interplay with multiple fates
Fernández-Pérez, Leandro
Guerra, Borja
Díaz-Chico, Juan C.
Flores-Morales, Amilcar
Ministerio de Economía y Competitividad (España)
European Commission
Gobierno de Canarias
Instituto Canario de Investigación del Cáncer
This is an open-access article distributed under the terms of the Creative Commons Attribution License.
The liver responds to estrogens and growth hormone (GH) which are critical regulators of body growth, gender-related hepatic functions, and intermediate metabolism. The effects of estrogens on liver can be direct, through the direct actions of hepatic ER, or indirect, which include the crosstalk with endocrine, metabolic, and sex-differentiated functions of GH. Most previous studies have been focused on the influence of estrogens on pituitary GH secretion, which has a great impact on hepatic transcriptional regulation. However, there is strong evidence that estrogens can influence the GH-regulated endocrine and metabolic functions in the human liver by acting at the level of GHR-STAT5 signaling pathway. This crosstalk is relevant because the widespread exposition of estrogen or estrogen-related compounds in human. Therefore, GH or estrogen signaling deficiency as well as the influence of estrogens on GH biology can cause a dramatic impact in liver physiology during mammalian development and in adulthood. In this review, we will summarize the current status of the influence of estrogen on GH actions in liver. A better understanding of estrogen-GH interplay in liver will lead to improved therapy of children with growth disorders and of adults with GH deficiency. © 2013 Fernández-Pérez, Guerra, Díaz-Chico and Flores-Morales.
2015-10-27T12:43:31Z
2015-10-27T12:43:31Z
2013
2015-10-27T12:43:32Z
artículo
Frontiers in Endocrinology 4: 66 (2013)
http://hdl.handle.net/10261/123934
10.3389/fendo.2013.00066
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000780
23761784
eng
Publisher's version
http://dx.doi.org/10.3389/fendo.2013.00066
Sí
http://creativecommons.org/licenses/by/4.0/
openAccess
Frontiers Media