2024-03-28T15:00:42Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1140742016-02-18T03:09:09Zcom_10261_105com_10261_1col_10261_358
2015-04-23T09:48:21Z
urn:hdl:10261/114074
Past and future approaches to ischemia-reperfusion lesion associated with liver transplantation
Casillas-Ramírez, Araní
Mosbah, Ismail Ben
Ramalho, Fernando Silva
Roselló-Catafau, Joan
Peralta, Carmen
Ischemia-reperfusion
Gene therapy
Liver transplantation
Preservation solutions
Pharmacological strategies
Ischemic preconditioning
Ischemia-reperfusion (I/R) injury associated with liver transplantation remains a serious complication in clinical practice, in spite of several attempts to solve the problem. The present review focuses on the complexity of I/R injury, summarizing conflicting results obtained from the literature about the mechanisms responsible for it. We also review the therapeutic strategies designed in past years to reduce I/R injury, attempting to explain why most of them have not been applied clinically. These strategies include improvements in pharmacological treatments, modifications of University of Wisconsin (UW) preservation solution based on a variety of additives, and gene therapy. Finally, we will consider new potential protective strategies using trimetazidine, 5-amino-4-imidazole carboxamide riboside (AICAR), melatonin, modulators of the renin-angiotensin system (RAS) and the phosphatidylinositol-3-OH kinase (PI3K)-Akt and the p42/p44 extracellular signal-regulated kinases (Erk 1/2) pathway. These strategies have shown promising results for I/R injury but have not been tested in experimental liver transplantation to date. Moreover, we will review ischemic preconditioning, taking into account the recent clinical studies that suggest that this surgical strategy could be appropriate for liver transplantation. © 2006 Elsevier Inc. All rights reserved.
2015-04-23T09:48:21Z
2015-04-23T09:48:21Z
2006-10-12
2015-04-23T09:48:21Z
artículo
Life Sciences 79(20): 1881-1894 (2006)
http://hdl.handle.net/10261/114074
10.1016/j.lfs.2006.06.024
eng
http://dx.doi.org/10.1016/j.lfs.2006.06.024
closedAccess
Elsevier