2024-03-29T12:47:18Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/889292021-12-28T15:47:47Zcom_10261_3284com_10261_1com_10261_54col_10261_3285col_10261_307
http://hdl.handle.net/10261/88929
10.1038/tp.2012.149
142534
Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia
Nature Publishing Group
2013
artículo
Urigüen, Leyre
Munarriz-Cuezva, E.
Pazos, Ángel
Castro, Elena
Sánchez-Blázquez, Pilar
rp12081
Ferrer-Alcón, M.
Pazos, Ángel
Garzón, Javier
rp13479
Meana, J. J.
2013
This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License.-- et al.
Overexpression of the mammalian homolog of the unc-18 gene (munc18-1) has been described in the brain of subjects with schizophrenia. Munc18-1 protein is involved in membrane fusion processes, exocytosis and neurotransmitter release. A transgenic mouse strain that overexpresses the protein isoform munc18-1a in the brain was characterized. This animal displays several schizophrenia-related behaviors, supersensitivity to hallucinogenic drugs and deficits in prepulse inhibition that reverse after antipsychotic treatment. Relevant brain areas (that is, cortex and striatum) exhibit reduced expression of dopamine D(1) receptors and dopamine transporters together with enhanced amphetamine-induced in vivo dopamine release. Magnetic resonance imaging demonstrates decreased gray matter volume in the transgenic animal. In conclusion, the mouse overexpressing brain munc18-1a represents a new valid animal model that resembles functional and structural abnormalities in patients with schizophrenia. The animal could provide valuable insights into phenotypic aspects of this psychiatric disorder.
Centro de Investigación Biomédica en Red Salud Mental (España)
Instituto de Salud Carlos III
Ministerio de Ciencia e Innovación (España)
Eusko Jaurlaritza
Universidad del País Vasco
Federación Española de Enfermedades Raras
Universidad Complutense de Madrid
Translational psychiatry
2013
3
e221