2024-03-28T09:26:20Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/813172016-02-17T16:59:18Zcom_10261_22com_10261_1col_10261_275
http://hdl.handle.net/10261/81317
10.4161/cbt.5.8.3118
85660
Long term responses with cetuximab therapy in glioblastoma multiforme
Landes Bioscience
2006
artículo
Belda-Iniesta, Cristobal
Castro Carpeño, Javier de
Casado, Enrique
Gutiérrez, Manuel
Perona Abellón, Rosario
González Barón, Manuel
2006
Open Access: License to Transfer or the CC-BY-NC.
Glioblastoma multiforme (GBM) is responsible for most of the deaths associated with primary brain tumors. Standard treatment includes maximal surgical resection followed by chemotherapy and concomitant radiotherapy. Most patients, however, recur shortly after treatment. Second line treatment has little efficacy and the majority of patients die soon from the disease. Recent advances in molecular biology have implicated the epidermal growth factor receptor (EGFR) signaling pathways in the progression and resistance to standard therapies for GBM. This has prompted the evaluation of EGFR tyrosine- kinase inhibitors with encouraging results. Cetuximab is a monoclonal antibody targeted against the extra cellular domain of the EGFR with activity against different tumor types, either alone or in combination with chemotherapy and/or radiation therapy. Here we describe three patients with recurrent, heavily pretreated, EGFR expressing GBM who responded to treatment with single agent cetuximab. ©2006 Landes Bioscience.
Cancer Biology and Therapy
2006
5
912
914