2024-03-28T16:45:20Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2401012022-05-01T04:30:30Zcom_10261_48com_10261_5col_10261_301
http://hdl.handle.net/10261/240101
10.1021/acs.orglett.1c01345
421523
Short and Modular Synthesis of Substituted 2-Aminopyrroles
American Chemical Society
2021
artículo
Diana-Rivero, Raquel
Halsvik, Beate
García-Tellado, Fernando
rp02101
Tejedor, David
rp13289
Hydrocarbons
Chemical reactions
Aromatic compounds
Rearrangement
Pyrroles
2021-04-30
We herein describe a simple and metal-free domino methodology to synthesize 2-aminopyrroles from alkynyl vinyl hydrazides. The domino reaction involves a novel propargylic 3,4-diaza-Cope rearrangement and a tandem isomerization/5-exo-dig N-cyclization reaction. By using this approach, a number of 2-aminopyrroles with diverse substituents have been prepared.
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
University of Oslo
Organic Letters 23(10): 4078–4082