2024-03-29T00:40:54Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2383172022-05-11T06:33:15Zcom_10261_11773com_10261_1col_10261_11774
http://hdl.handle.net/10261/238317
10.1016/j.ebiom.2020.103077
419674
High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients
Elsevier
2020
artículo
Yeregui, Elena
Viladés, Consuelo
Domingo, Pere
Ceausu, Andra
Pacheco, Yolanda M.
Veloso, Sergi
Inciarte, Alexy
Vidal-González, Judit
Peraire, Maria
Perpiñán, Carles
Falcó, Vicenç
Masip, Jenifer
Alba, Verónica
Vargas, Montserrat
Martí, Anna
Reverté, Laia
Mallolas, Josep
Vidal, Francesc
Peraire, Joaquim
Rull, Anna
Chemokines
Chemokine receptors
HIV
Poor immune recovery
Polymorphisms variants
2020-12
© 2020 The Authors.
[Background]: The underlying mechanisms of incomplete immune reconstitution in treated HIV-positive patients are very complex and may be multifactorial, but perturbation of chemokine secretion could play a key role in CD4+ T-cell turnover.
[Methods]: We evaluated the circulating baseline and 48-week follow-up concentrations of SDF-1/CXCL12, fractalkine/CX3CL1, MCP-1/CCL2, MIP-α/CCL3, MIP-β/CCL4 and RANTES/CCL5, and we estimated their association with CXCL12, CX3CR1, CCR2, CCL5 and CCR5 single nucleotide polymorphisms (SNPs) to investigate multiple chemokine-chemokine receptor signatures associated with immune dysregulation preceding poor immune recovery.
[Findings]: The circulating concentrations and gene expression patterns of SDF-1/CXCL12 (CXCL12 rs1801157) and MCP-1/CCL2 (CCR2 rs1799864_814) were associated with immune recovery status. CCR2 rs1799864_814 and CCR5 rs333_814 (Δ32) determine the baseline plasma RANTES and MIP-α concentrations, respectively, in participants with poor immune response.
[Interpretation]: SDF-1/CXCL12 and MCP-1/CCL2 could be considered prognostic markers of immune failure despite suppressive antiretroviral therapy. The strong linkage disequilibrium (LD) between CCR2 rs1799864_814 and CCR5 rs1800024 indicated that the alleles of each gene are inherited together more often than would be expected by chance.
Instituto de Salud Carlos III
European Commission
Generalitat de Catalunya
Junta de Andalucía
EBioMedicine
2020
62
103077