Título,Autor,palabras clave,Fecha publicación,Editor,citación,Resumen,url,doi,issn,isbn,tipología "Exposure to hexachlorobenzene during pregnancy and children's social behavior at 4 years of age","Ribas-Fitó, Núria; Torrent, Maties; Carrizo, Daniel; Júlvez, Jordi; Grimalt, Joan O.; Sunyer, Jordi","Behavior; Children; Cord serum; Hexachlorobenzene (HCB); Hyperactivity; Prenatal exposure; Social competence","2007-03","National Institute of Environmental Health Sciences (U.S.)","Environmental Health Perspectives 115(3): 447-450 (2007)","[Background] Hexachlorobenzene (HCB) is an organochlorine chemical that has been used inagriculture and industrial processes. Behavioral impairment after HCB exposure has been describedin animal models, but little information is available in humans.; [Objectives] Our goal was to study the association of prenatal exposure to HCB with the social behavior of preschool children.; [Methods] Two birth cohorts in Ribera d?Ebre and Menorca (Spain) were set up between 1997 and1999 (n = 475). The California Preschool Social Competence Scale and the Attention-DeficitHyperactivity Disorder (ADHD) were scored by each 4-year-old child?s teacher. Organochlorinecompounds were measured in cord serum. Children?s diet and parental sociodemographic information were obtained through questionnaire.; [Results] Children with concentrations of HCB > 1.5 ng/mL at birth had a statistically significant increased risk of having poor Social Competence [relative risk (RR) = 4.04; 95% confidence interval (CI), 1.76?9.58] and ADHD (RR = 2.71; 95% CI, 1.05?6.96) scores. No association was found between HCB and the cognitive and psychomotor performance of these children.; [Conclusions] Prenatal exposure to current concentrations of HCB in Spain is associated with a decrease in the behavioral competence at preschool ages. These results should be considered when evaluating the potential neurotoxicologic effects of HCB.","http://hdl.handle.net/10261/10449","10.1289/ehp.9314","0091-6765","","Artículo"