Título,Autor,palabras clave,Fecha publicación,Editor,citación,Resumen,url,doi,issn,isbn,tipología "Transcriptomal profiling of the cellular response to DNA damage mediated by Slug (Snai2)","Pérez-Caro, M.; Bermejo-Rodríguez, C.; Sánchez García, Isidro; González-Herrero, Inés","Snai2; MEFs; Microarray analysis; Stem cells; DNA damage","2008","Nature Publishing Group","British Journal of Cancer 98(2): 480-488 (2008)","Snai2-deficient cells are radiosensitive to DNA damage. The function of Snai2 in response to DNA damage seems to be critical for itsfunction in normal development and cancer. Here, we applied a functional genomics approach that combined gene-expressionprofiling and computational molecular network analysis to obtain global dissection of the Snai2-dependent transcriptional response toDNA damage in primary mouse embryonic fibroblasts (MEFs), which undergo p53-dependent growth arrest in response to DNAdamage. Although examination of the response showed that overall expression of p53 target gene expression patterns was similarlyaltered in both control and Snai2-deficient cells, we have identified and validated candidate Snai2 target genes linked to Snai2 genefunction in response to DNA damage. This work defines for the first time the effect of Snai2 on p53 target genes in cells undergoinggrowth arrest, elucidates the Snai2-dependent molecular network induced by DNA damage, points to novel putative Snai2 targets,and suggest a mechanistic model, which has implications for cancer management.","http://hdl.handle.net/10261/6250","10.1038/sj.bjc.6604084","0007-0920","","Artículo"