1. DIGITAL.CSIC

León, Rafael

Network Lab View Statistics Email Alert RSS Feed

Perfil

Foto_Rafael-León_2-nzhim8wzkdgnidyugcfcxa4puwkdscv1osfh11wwng.jpg picture
 
Firma en Digital.CSIC (*)
León, Rafael
 
Centro o Instituto
CSIC - Instituto de Quimica Medica (IQM)
 
Categoría Profesional
Científico titular
 
Email
rafael.leon@iqm.csic.es
 
ORCID
 
WoS ResearcherID - Publons
 
Scopus AuthorID
 
Otros identificadores (con url)
 

Publications

Results 1-20 of 34 (Search time: 0.04 seconds).

RightsPreviewIssue DateTitleAuthor(s)Type
1openAccessWO2011051527A1.pdf.jpg5-May-20111,8-Naphthyridine-devired compounds and the use thereof in the treatment of neurodegenerative diseasesRíos Salgado, Cristóbal; Romero Martínez, Alejandro; Egea, Javier; León, Rafael CSIC ORCID ; Villarroya Sánchez, Mercedes; García López, Manuela; García García, Antonio; Marco-Contelles, José CSIC ORCID; Soriano, Elena CSIC; Samadi, Abdelouahid CSIC ORCID; Chioua, Mourad CSIC ORCID artículo
2closedAccessaccesoRestringido.pdf.jpg2012Benzothiazepine CGP37157 and its isosteric 2′-ethyl analogue provide neuroprotection and block cell calcium entryGonzález-Lafuente, Laura; Egea, Javier; León, Rafael CSIC ORCID ; Martínez-Sanz, Francisco J.; Monjas, Leticia CSIC ORCID; Pérez, Concepción CSIC ORCID; Merino, Cristina CSIC; García-De Diego. Antonio M.; Rodríguez-Franco, María Isabel CSIC ORCID ; García, Antonio G.; Villarroya, Mercedes; López, Manuela G.; Ríos, Cristóbal de losartículo
3openAccessantioxidants-10-00941-v3.pdf.jpg2021Bisavenathramide analogues as nrf2 inductors and neuroprotectors in in vitro models of oxidative stress and hyperphosphorylationCores, Ángel; Abril, S.; Michalska, Patrycja; Duarte, Pablo; Olives, A. I.; Martín, M. A.; Villacampa, Mercedes; León, Rafael CSIC ORCID ; Menéndez, José Carlosartículo
4openAccessCurcumin-piperlongumine_PV_Art2022.pdf.jpg2022Curcumin-piperlongumine hybrids with a multitarget profile elicit neuroprotection in in vitro models of oxidative stress and hyperphosphorylationCores, Ángel; Carmona-Zafra, Noelia; Martín-Cámara, Olmo; Sánchez, Juan Domingo; Duarte, Pablo; Villacampa, Mercedes; Bermejo-Bescós, Paloma; Martín-Aragón, Sagrario; León, Rafael CSIC ORCID ; Menéndez, José Carlosartículo
5openAccesstherapeuticstrategyAlzheimer.pdf.jpg2017Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's diseaseGameiro, Isabel; Michalska, Patrycja; Tenti, Giammarco; Cores, Ángel; Buendía Abaitua, Izaskun; Rojo, Ana I. CSIC ORCID; Georgakopoulos, Nikolaos D.; Hernández, Jesús M. CSIC ORCID ; Ramos, María Teresa; Wells, Geoffrey; López, Manuela G.; Cuadrado, Antonio CSIC ORCID; Menéndez, Carlos; León, Rafael CSIC ORCID artículo
6closedAccessAcceso_restringido.pdf.jpg15-Feb-2022Early Use of Sarilumab in Patients Hospitalized with COVID-19 Pneumonia and Features of Systemic Inflammation: the SARICOR Randomized Clinical TrialMerchante, Nicolás CSIC ORCID; Cárcel Fernández, Sheila; Garrido-Gracia, José Carlos; Trigo, Marta; Esteban-Moreno, M. Ángeles; León, Rafael CSIC ORCID ; Espíndola-Gómez, Reinaldo; Aguilar Alonso, Eduardo; Vinuesa García, David; Romero Palacios, Alberto; Pérez-Camacho, Inés; Gutiérrez-Gutiérrez, Belén CSIC ORCID; Martínez-Marcos, Francisco Javier; Fernández-Roldán, Concepción; Martínez Pérez-Crespo, Pedro María CSIC ORCID; Aceituno Caño, Alexandra; León Jiménez, Eva CSIC; Corzo, Juan E.; Fuente, Carmen de la; Torre-Cisneros, Juliánartículo
7openAccessSARICOR_STUDY.pdf.jpg14-Nov-2020Efficacy and safety of early treatment with sarilumab in hospitalised adults with COVID-19 presenting cytokine release syndrome (SARICOR STUDY): protocol of a phase II, open-label, randomised, multicentre, controlled clinical trialLeón, Rafael CSIC ORCID ; Cárcel Fernández, Sheila; Limia Pérez, Laura; Romero Palacios, Alberto; Fernández-Roldan, Concepción; Aguilar Alonso, Eduardo; Pérez-Camacho, Inés; Rodríguez-Baño, Jesús CSIC ORCID; Merchante, Nicolás CSIC ORCID; Olalla, Julián; Esteban-Moreno, M. Ángeles; Santos, Marta; Luque-Pineda, Antonio; Torre-Cisneros, Juliánartículo
8openAccessantioxidants-11-00112-v2.pdf.jpg4-Jan-2022Enantioselective Synthesis and Pharmacological Evaluation of Aza-CGP37157–Lipoic Acid Hybrids for the Treatment of Alzheimer’s DiseaseCores, Ángel; Michalska, Patrycja; Pérez, José Miguel; Crisman, Enrique CSIC; Gómez, Clara; Villacampa, Mercedes; Menéndez, José Carlos; León, Rafael CSIC ORCID artículo
9openAccesspharmaceutics-13-01609.pdf.jpg2021Enhanced stability and bioactivity of natural anticancer topoisomerase i inhibitors through cyclodextrin complexationGonzález-Ruiz, Victor; Cores, Ángel; Martín-Cámara, Olmo; Orellana, K.; Cervera-Carrascón, V.; Michalska, Patrycja; Olives, A. I.; León, Rafael CSIC ORCID ; Martín, M. A.; Menéndez, José Carlosartículo
10openAccessaccesoRestringido.pdf.jpg2017Enzymatic and solid-phase synthesis of new donepezil-based L- and D-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemiaMonjas, Leticia CSIC ORCID; Arce, Mariana P. CSIC; León, Rafael CSIC ORCID ; Egea, Javier; Pérez, Concepción CSIC ORCID; Villarroya, Mercedes; López, Manuela G.; Gil, Carmen CSIC ORCID ; Conde, Santiago CSIC; Rodríguez-Franco, María Isabel CSIC ORCID artículo
11openAccess1-s2.0-S0169136823000513-main.pdf.jpg1-Mar-2023Evidence of rare earth elements origin in acid mine drainage from the Iberian Pyrite Belt (SW Spain)León, Rafael CSIC ORCID ; Macías, F. CSIC ORCID; Cánovas, Carlos R.; Millán-Becerro, Ricardo; Pérez-López, Rafael; Ayora, Carlos CSIC ORCID; Nieto, José Miguelartículo
12openAccessGeochemical behavior of rare earth elements in acid drainages Modeling achievements and limitations.pdf.jpgSep-2020Geochemical behavior of rare earth elements in acid drainages: Modeling achievements and limitationsLozano, Alba; Ayora, Carlos CSIC ORCID; Macías, F. CSIC ORCID; Gimeno, María José; León, Rafael CSIC ORCID ; Auqué, Luisartículo
13closedAccessaccesoRestringido.pdf.jpg21-May-2020Impact of KPC Production and High-Level Meropenem Resistance on All-Cause Mortality of Ventilator-Associated Pneumonia in Association with Klebsiella pneumoniaeRivera-Espinar, Francisco; Machuca, Isabel; Tejero, Rocío; Rodríguez, Jorge; Mula, Ana; Marfil-Pérez, Eduardo; Cano, Ángela; Gutiérrez-Gutiérrez, Belén CSIC ORCID; Rodríguez, Marina; Pozo, Juan Carlos; Fuente, Carmen de la; Rodríguez-Baño, Jesús CSIC ORCID; Martínez-Martínez, Luis; León, Rafael CSIC ORCID ; Torre-Cisneros, Juliánartículo
14openAccessMedicinal Research Reviews - 2022 - Crisman - KEAP1‐NRF2 protein protein interaction inhibitors Design pharmacological.pdf.jpg2023KEAP1-NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potentialCrisman, Enrique CSIC; Duarte, Pablo; Dauden, Esteban; Cuadrado, Antonio CSIC ORCID; Rodríguez-Franco, María Isabel CSIC ORCID ; López, Manuela G.; León, Rafael CSIC ORCID artículo de revisión
15openAccessMed Res Rev. 2022.pdf.jpg2022KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potentialCrisman, Enrique CSIC; Duarte, Pablo; Dauden, Esteban; Cuadrado, Antonio CSIC ORCID; Rodríguez-Franco, María Isabel CSIC ORCID ; López,Manuela G.; León, Rafael CSIC ORCID artículo
16closedAccessaccesoRestringido.pdf.jpg2020Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerizationMichalska, Patrycja; Buendía Abaitua, Izaskun; Duarte, Pablo; Fernández-Mendívil, Cristina; Negredo, Pilar; Cuadrado, Antonio CSIC ORCID; López, Manuela G.; León, Rafael CSIC ORCID artículo
17openAccessGEXPLO-D-20-00043_R1.pdf.jpgMay-2021Mine waters as a secondary source of rare earth elements worldwide: The case of the Iberian Pyrite BeltLeón, Rafael CSIC ORCID ; Macías, F. CSIC ORCID; Cánovas, Carlos R.; Pérez-López, Rafael; Ayora, Carlos CSIC ORCID; Nieto, José Miguel; Olías, Manuelartículo
18closedAccessaccesoRestringido.pdf.jpg2017Mortality Associated with Bacteremia Due to Colistin-Resistant Klebsiella pneumoniae with High-Level Meropenem Resistance: Importance of Combination Therapy without Colistin and CarbapenemsMachuca, Isabel; Gutiérrez-Gutiérrez, Belén CSIC ORCID; Gracia-Ahufinger, Irene; Rivera-Espinar, Francisco; Cano, Ángela; Guzmán-Puche, Julia; Pérez-Nadales, Elena; Natera, Clara; Rodríguez, Marina; León, Rafael CSIC ORCID ; Castón, Juan José; Rodríguez-López, Fernando; Rodríguez-Baño, Jesús CSIC ORCID; Torre-Cisneros, Juliánartículo
19openAccessDrugRepurposing.pdf.jpg17-Jul-2020Multitarget Virtual Screening for Drug Repurposing in COVID19Sorzano, Carlos Óscar S.; Crisman, Enrique CSIC; Carazo, José M.; León, Rafael CSIC ORCID artículo
20closedAccess2011N-Acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer’s diseaseGonzález Muñoz, Gema C.; Arce, Mariana P. CSIC; López, Beatriz; López, Beatriz; Romero, Alejandro CSIC ORCID; del Barrio, Laura; Martín de Saavedra, María Dolores; Egea, Javier; León, Rafael CSIC ORCID ; Villarroya, Mercedes; López, Manuela G.; García, Antonio G.; Conde, Santiago CSIC; Rodríguez-Franco, María Isabel CSIC ORCID artículo