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Lucena-Agell, Daniel

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Firma en Digital.CSIC (*)
Lucena-Agell, Daniel
 
Centro o Instituto
CSIC - Centro de Investigaciones Biologicas Margarita Salas (CIB)
 
Departamento
Biología Estructural y Química
 
Especialización
Agentes estabilizantes de microtúbulos
 
Email
lucena@cib.csic.es
 
ORCID
 
WoS ResearcherID - Publons
 
Scopus AuthorID
 
Otros - ResearchGate
 

Publications

Refined By:
Autor:  Díaz, José Fernando

Resultados 1-20 de 24.

DerechosPreviewFecha Public.TítuloAutor(es)Tipo
1openAccessNature Communications_Menchon_2018.pdf.jpg29-may-2018A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulinMenchon, Grégory; Lucena-Agell, Daniel CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Steinmetz, Michel O.artículo
2closedAccessaccesoRestringido.pdf.jpg26-ago-2016Aggregated compound biological signatures facilitate phenotypic drug discovery and target elucidationCortés Cabrera, Álvaro CSIC ORCID; Lucena-Agell, Daniel CSIC ORCID ; Redondo-Horcajo, Mariano CSIC ORCID ; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID ; Fasching, Bernhard; Petrone, Paula M.artículo
3openAccessStructure_Estévez-Gallego_2022.pdf.jpg5-ene-2023Chemical modulation of microtubule structure through the laulimalide/peloruside siteEstévez-Gallego, Juan CSIC ORCID ; Álvarez-Bernad, Beatriz CSIC; Benet, Pera; Wullschleger, Christoph; Raes, Olivier; Menche, Dirk; Martínez, Juan Carlos; Lucena-Agell, Daniel CSIC ORCID ; Prota, Andrea E.; Bonato, Francesca CSIC ORCID; Bargsten, Katja; Cornelus, Jelle; Giménez-Abián, Juan F. CSIC ; Northcote, Peter; Steinmetz, Michel O.; Kamimura, Shinji; Altmann, Karl-Heinz; Paterson, Ian; Gago, Federico CSIC ORCID; Van der Eycken, Johan; Díaz, José Fernando CSIC ORCID ; Oliva, María A. CSIC ORCID artículo
4embargoedAccessEuropean Journal of Medicinal Chemistry_Campiani_2022.pdf.jpg5-may-2022Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacyCampiani, Giuseppe; Khan, Tuhina; Ulivieri, Cristina; Staiano, Leopoldo; Papulino, Chiara; Magnano, Stefania; Nathwani, Seema; Ramunno, Anna; Lucena-Agell, Daniel CSIC ORCID ; Relitti, Nicola; Federico, Stefano; Pozzetti, Luca; Carullo, Gabriele; Casagni, Alice; Brogi, Simone; Vanni, Francesca; Galatello, Paola; Ghanim, Magda; McCabe, Niamh; Lamponi, Stefania; Valoti, M.; Ibrahim, Ola; O'Sullivan, Jeff; Turkington, Richard; Kelly, Vincent P.; VanWemmel, Ruben; Díaz, José Fernando CSIC ORCID ; Gemma, Sandra; Zisterer, Daniela M.; Altucci, Lucia; De Matteis, Antonella; Butini, Stefania; Benedetti, Rosariaartículo
5closedAccessaccesoRestringido.pdf.jpg6-oct-2021Design, synthesis, and in vitro evaluation of tubulin-targeting dibenzothiazines with antiproliferative activity as a novel heterocycle building blockGuerra, Walter D.; Lucena-Agell, Daniel CSIC ORCID ; Hortigüela, Rafael CSIC ORCID; Rossi, Roberto A.; Díaz, José Fernando CSIC ORCID ; Padrón, José M.; Barolo, Silvia M.artículo
6openAccessijms-23-03448-v2.pdf.jpg22-mar-2022Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport FunctionOliva, María A. CSIC ORCID ; Tosat-Bitrian, Carlota CSIC ORCID ; Barrado-Gil, Lucía CSIC ORCID; Bonato, Francesca CSIC ORCID; Galindo Barreales, Inmaculada; Garaigorta, Urtzi ; Álvarez-Bernad, Beatriz CSIC; París-Ogáyar, Rebeca CSIC ORCID; Lucena-Agell, Daniel CSIC ORCID ; Giménez-Abián, Juan F. CSIC ; García-Dorival, Isabel; Urquiza, Jesús; Gastaminza, Pablo CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Palomo, Valle CSIC ORCID ; Alonso Martí, Covadongaartículo
7openAccessPNAS_Matthew_2020.pdf.jpg2-mar-2021Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological siteMatthew, S.; Chen, Qi-Yin; Ratnayake, R.; Fermaintt, Charles S.; Lucena-Agell, Daniel CSIC ORCID ; Bonato, Francesca CSIC ORCID; Prota, Andrea E.; Lim, Seok Ting; Wang, Xiaomeng; Díaz, José Fernando CSIC ORCID ; Risinger, April L.; Paul, Valerie J.; Oliva, María A. CSIC ORCID ; Luesch, H.artículo
8openAccessPNAS_.Unterhauser_2019.pdf.jpg26-feb-2019Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubulestabilizing activitiesUnterhauser, Katrin; Poltl, Lisa; Schneditz, Georg; Kienesberger, Sabine; Glabonjat, Ronald A.; Kitsera, Maksym; Pletz, Jakob; Josa-Prado, Fernando CSIC ORCID; Dornisch, Elisabeth; Lembacher-Fadum, Christian; Roier, Sandro; Gorkiewicz, Gregor; Lucena-Agell, Daniel CSIC ORCID ; Barasoain, Isabel CSIC ; Kroutil, Wolfgang; Wiedner, Marc; Loizou, Joanna I.; Breinbauer, Rolf; Díaz, José Fernando CSIC ORCID ; Schild, Stefan; Hog̈enauer, Christoph; Zechner, Ellen L.artículo
9openAccesschemistry_marzullo_2021.pdf.jpgnov-2021Maytansinol derivatives: side reactions as a chance for new tubulin bindersMarzullo, Paola; Boiarska, Zlata; Pérez-Peña, Helena; Abel, Anne-Catherine; Álvarez-Bernad, Beatriz CSIC; Lucena-Agell, Daniel CSIC ORCID ; Vasile, Francesca; Sironi, Maurizio; Altmann, Karl-Heinz; Prota, Andrea E.; Díaz, José Fernando CSIC ORCID ; Pieraccini, Stefano; Passarella, D.artículo
10closedAccessaccesoRestringido.pdf.jpg24-ene-2023Maytansinol functionalization:towards useful probes for studying microtubule dynamicsBoiarska, Zlata; Pérez-Peña, Helena; Abel, Anne-Catherine; Marzullo, Paola; Álvarez-Bernad, Beatriz CSIC; Bonato, Francesca CSIC ORCID; Santini, Benedetta; Horvath, Dragos; Lucena-Agell, Daniel CSIC ORCID ; Vasile, Francesca; Sironi, Maurizio; Díaz, José Fernando CSIC ORCID ; Prota, Andrea E.; Pieraccini, Stefano; Passarella, D.artículo
11openAccess2017 Tang et al.pdf.jpg3-jun-2017Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions.Tang, Yong; Rodríguez-Salarichs, Javier CSIC; Estévez-Gallego, Juan CSIC ORCID ; Balaguer, Francisco de Asís CSIC ORCID; Redondo-Horcajo, Mariano CSIC ORCID ; Lucena-Agell, Daniel CSIC ORCID ; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID ; Fang, Wei-Shuoartículo
12embargoedAccessEuropean Journal of Medicinal Chemistry_Ma et al._2023.pdf.jpg5-nov-2023Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potencyMa, Yuntao; Josa-Prado, Fernando CSIC ORCID; Essif, Jacob Nathaniel; Liu, Shuqi; Li, Shuo; Lucena-Agell, Daniel CSIC ORCID ; Chan, Peter; Goossens, Kenneth; Hortigüela, Rafael CSIC ORCID; Matesanz, Ruth CSIC ; Wang, Yingjie; Gago, Federico CSIC ORCID; Wang, Hongbo; Risinger, April L.; Díaz, José Fernando CSIC ORCID ; Fang, Wei-Shuoartículo
13openAccessCancer Cell International_Keenan_2020.pdf.jpg2020N‑alkylisatin‑based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicityKeenan, Bryce; Finol-Urdaneta, Rocío; Hope, Ashleigh; Bremner, John B.; Kavallaris, Maria; Lucena-Agell, Daniel CSIC ORCID ; Oliva, María A. CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Vine, Kara L.artículo
14openAccessjournal of medicinal chemistry_lucena-agell_2024.pdf.jpg31-ene-2024PM534, an optimized target-protein interaction strategy through the colchicine site of tubulinLucena-Agell, Daniel CSIC ORCID ; Guillén, María José; Matesanz, Ruth CSIC ; Álvarez-Bernad, Beatriz CSIC; Hortigüela, Rafael CSIC ORCID; Avilés, Pablo; Martínez-Díez, Marta; Santamaría, Gema; Contreras, Julia CSIC; Plaza-Menacho, Iván; Giménez-Abián, Juan F. CSIC ; Oliva, María A. CSIC ORCID ; Cuevas, Carmen; Díaz, José Fernando CSIC ORCID artículo
15openAccessiscience_Cury_2019.pdf.jpg22-nov-2019Structural basis of colchicine-site targeting acylhydrazones active against multidrug-resistant acute lymphoblastic leukemiaCury, Nathália Moreno; Mühlethaler, Tobias; Laranjeira, Angelo Brunelli Albertoni; Canevarolo, Rafael Renatino; Zenatti, Priscila Pini; Lucena-Agell, Daniel CSIC ORCID ; Barasoain, Isabel CSIC ; Song, Chunhua; Sun,Dongxiao; Dovat, Sinisa; Yunes, Rosendo Augusto; Prota, Andrea E.; Steinmetz, Michel O.; Díaz, José Fernando CSIC ORCID ; Yunes, José Andrésartículo
16openAccesselife_prota_2023.pdf.jpg6-mar-2023Structural insight into the stabilization of microtubules by taxanesProta, Andrea E.; Lucena-Agell, Daniel CSIC ORCID ; Ma, Yuntao; Estévez-Gallego, Juan CSIC ORCID ; Li, Shuo; Bargsten, Katja; Josa-Prado, Fernando CSIC ORCID; Altmann, Karl-Heinz; Gaillard, Natacha; Kamimura, Shinji; Mühlethaler, Tobias; Gago, Federico CSIC ORCID; Oliva, María A. CSIC ORCID ; Steinmetz, Michel O.; Fang, Wei-Shuo; Díaz, José Fernando CSIC ORCID artículo
17openAccesselife-Estévez-Gallego-2020.pdf.jpg10-mar-2020Structural model for differential cap maturation at growing microtubule endsEstévez-Gallego, Juan CSIC ORCID ; Josa-Prado, Fernando CSIC ORCID; Ku, Siou; Martínez Buey, Rubén CSIC ORCID; Balaguer, Francisco de Asís CSIC ORCID; Prota, Andrea E.; Lucena-Agell, Daniel CSIC ORCID ; Kamma-Lorger, C.S.; Yagi, Toshiki; Iwamoto, Hiroyuki; Duchesne, Laurence; Barasoain, Isabel CSIC ; Steinmetz, Michel O.; Chrétien, Denis; Kamimura, Shinji; Díaz, José Fernando CSIC ORCID ; Oliva, María A. CSIC ORCID artículo
18closedAccessaccesoRestringido.pdf.jpg15-ene-2019Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agentsBrindisi, Margherita; Ulivieri, Cristina; Alfano, Gloria; Gemma, Sandra; Balaguer, Francisco de Asís CSIC ORCID; Khan, Tuhina; Grillo, Alessandro; Chemi, Giulia; Menchon, Grégory; Prota, Andrea E.; Olieric, Natacha; Lucena-Agell, Daniel CSIC ORCID ; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID ; Nebbioso, Angela; Conte, Mariarosaria; Lopresti, Ludovica; Magnano, Stefania; Amet, Rebecca; Kinsella, Paula; Zisterer, Daniela M.; Ibrahim, Ola; O'Sullivan, Jeff; Morbidelli, Lucia; Spaccapelo, Roberta; Baldari, Cosima T.; Butini, Stefania; Novellino, Ettore; Campiani, Giuseppe; Altucci, Lucia; Steinmetz, Michel O.; Brogi, Simoneartículo
19closedAccessaccesoRestringido.pdf.jpg26-feb-2021Studies toward the synthesis of an oxazole-based analog of (−)-zampanolideBold, Christian Paul; Klaus, Cindy; Pfeiffer, Bernhard; Schürmann, Jasmine; Lombardi, Rafael; Lucena-Agell, Daniel CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinzartículo
20openAccessAngew Chem Int Ed - 2022 - Bold - Synthesis and Biological Evaluation of C 13 C 13 ‐Bis desmethyl disorazole Z.pdf.jpg25-oct-2022Synthesis and biological evaluation of C(13)/C(13′)-Bis(desmethyl)disorazole Z**Bold, Christian Paul; Lucena-Agell, Daniel CSIC ORCID ; Oliva, María A. CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinzartículo