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Martínez-González, Loreto

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Firma en Digital.CSIC (*)
Martínez-González, Loreto
 
Centro o Instituto
CSIC - Centro de Investigaciones Biologicas Margarita Salas (CIB)
 
Departamento
Biología Estructural y Química
 
Especialización
Química Médica y Biológica traslacional
 
Email
loretomg@cib.csic.es
 
Scopus AuthorID
 

Publications

Resultados 1-20 de 21.

DerechosPreviewFecha Public.TítuloAutor(es)Tipo
1openAccessACSChemNeurosci 2018.pdf.jpg9-oct-2018A focused library of psychotropic analogs with neuroprotective and neuroregenerative potentialUliassi, Elisa; Peña-Altamira, Luis Emiliano; Morales, Aixa V. CSIC ORCID; Massenzio, Francesca; Petralla, Sabrina; Rossi, Michele; Roberti, Marinella; Martínez-González, Loreto CSIC ORCID ; Martínez Gil, Ana CSIC ORCID ; Monti, B.; Bolognesi, Maria Lauraartículo
2openAccessNeurobiology of Disease_Cuevas_2024.pdf.jpgmar-2024Casein kinase 1 inhibitor avoids TDP-43 pathology propagation in a patient-derived cellular model of amyotrophic lateral sclerosisCuevas, Eva P. CSIC ORCID ; Martínez-González, Loreto CSIC ORCID ; Gordillo, Clara; Tosat-Bitrian, Carlota CSIC ORCID ; Pérez de la Lastra, Carmen; Sáenz, Amets; Gil, Carmen CSIC ORCID ; Palomo, Valle CSIC ORCID ; Martín-Requero, Ángeles CSIC ORCID ; Martínez Gil, Ana CSIC ORCID artículo
3closedAccessaccesoRestringido.pdf.jpg2018Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitorsChierrito, Talita P. C.; Pedersoli-Mantoani, S.; Roca, Carlos CSIC ORCID; Sebastián-Pérez, Víctor; Martínez-González, Loreto CSIC ORCID ; Pérez, Daniel I. CSIC ORCID; Pérez, Concepción CSIC ORCID; Canales, Ángeles CSIC ORCID; Cañada, F. Javier ; Campillo, Nuria E. CSIC ORCID ; Carvalho, Ivone; Martínez Gil, Ana CSIC ORCID artículo
4openAccessJEIMC_Sciú_2018.pdf.jpg1-ene-2019Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3Sciú, María Lourdes; Sebastián-Pérez, Víctor; Martínez-González, Loreto CSIC ORCID ; Benítez, Rocio; Pérez, Daniel I. CSIC ORCID; Pérez, Concepción CSIC ORCID; Campillo, Nuria E. CSIC ORCID ; Martínez Gil, Ana CSIC ORCID ; Moyano, Elizabeth Lauraartículo
5closedAccessaccesoRestringido.pdf.jpg2018Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function RegulatorsRoca, Carlos CSIC ORCID; Martínez-González, Loreto CSIC ORCID ; Daniel-Mozo, Miguel CSIC ORCID; Sastre, J. CSIC; Infantes, L. CSIC ORCID; Mansilla, A.; Chaves Sanjuán, Antonio CSIC ORCID; González-Rubio, Juana M. CSIC; Gil, C CSIC ORCID; Cañada, F. Javier ; Martínez, A.; Sánchez-Barrena, María José CSIC ORCID; Campillo, Nuria E. CSIC ORCID artículo
6openAccessmolecules-24-01307.pdf.jpg3-abr-2019Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer’s DiseaseKohelová, Eliška; Peřinová, Rozálie; Maafi, Negar; Korábečný, Jan; Hulcová, Daniela; Maříková, Jana; Kučera, Tomáš; Martínez-González, Loreto CSIC ORCID ; Hrabinová, Martina; Vorčáková, Katarina; Nováková, Lucie; De Simone, Angela; Havelek, Radim; Cahlíková, Lucieartículo
7openAccessJournal of Enzyme Inhibition and Medicinal Chemistry_Rojas-Prats_2024.pdf.jpg11-ene-2024Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinaseRojas-Prats, Elisa CSIC ORCID; Martínez-González, Loreto CSIC ORCID ; Gil, Carmen CSIC ORCID ; Ramírez, David; Martínez Gil, Ana artículo
8openAccess16-feb-2023Emerging clinical investigational drugs for the treatment of amyotrophic lateral sclerosisMartínez-González, Loreto CSIC ORCID ; Martínez Gil, Ana CSIC ORCID artículo
9openAccesspharmaceutics_rojas-prats_2021.pdf.jpg28-ene-2021Increasing brain permeability of PHA-767491, a cell division cycle 7 kinase inhibitor, with biodegradable polymeric nanoparticlesRojas-Prats, Elisa CSIC ORCID; Tosat-Bitrian, Carlota CSIC ORCID ; Martínez-González, Loreto CSIC ORCID ; Nozal, Vanesa CSIC ORCID; Pérez, Daniel I. CSIC ORCID; Martínez Gil, Ana CSIC ORCID artículo
10openAccessNature Communications_Canal-Martín_2019.pdf.jpg26-jun-2019Insights into real-time chemical processes in a calcium sensor protein-directed dynamic libraryCanal-Martín, Andrea CSIC ORCID; Sastre, Javier CSIC ORCID; Sánchez-Barrena, María José CSIC ORCID; Canales, Ángeles CSIC ORCID; Baldominos, Sara; Pascual, Naiara; Martínez-González, Loreto CSIC ORCID ; Molero, Dolores; Fernández-Valle, Encarnación; Sáez, Elena; Blanco-Gabella, Patricia; Gomez-Rubio, Elena CSIC ORCID; Martín-Santamaría, Sonsoles CSIC ORCID ; Sáiz, Almudena CSIC ORCID; Mansilla, A.; Cañada, F. Javier ; Jiménez-Barbero, Jesús CSIC ORCID; Martínez Gil, Ana CSIC ORCID ; Pérez-Fernández, Ruth CSIC ORCID artículo
11closedAccessaccesoRestringido.pdf.jpg2017Interference of the complex between NCS-1 & Ric8a with phenothiazines regulates synaptic function & is an approach for fragile X syndromeMansilla, Alicia CSIC ORCID; Chaves Sanjuán, Antonio CSIC ORCID; Campillo, Nuria E. CSIC ORCID ; Semelidou, O.; Martínez-González, Loreto CSIC ORCID ; Infantes, L. CSIC ORCID; González-Rubio, Juana M. CSIC; Gil, Carmen CSIC ORCID ; Conde, Santiago CSIC; Skoulakis, E.M.C.; Ferrús, Alberto CSIC ORCID; Martínez Gil, Ana CSIC ORCID ; Sánchez-Barrena, María José CSIC ORCIDartículo
12openAccessScientific Reports_Martínez-González_2020.pdf.jpg10-mar-2020Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatmentMartínez-González, Loreto CSIC ORCID ; Rodríguez-Cueto, Carmen; Cabezudo, Diego; Bartolomé Robledo, Fernando CSIC ORCID; Andrés-Benito, Pol; Ferrer, Isidro; Gil, Carmen CSIC ORCID ; Martín-Requero, Ángeles CSIC ORCID ; Fernández-Ruiz, Javier; Martínez Gil, Ana CSIC ORCID ; De Lago, E.artículo
13openAccess14-jul-2020Novel Curcumin-Diethyl Fumarate Hybrid as a dualistic GSK-3β inhibitor/Nrf2 inducer for the treatment of Parkinson’s diseaseDi Martino, Rita Maria Concetta; Pruccoli, Letizia; Bisi, Alessandra; Gobbi, Silvia; Rampa, Angela; Martínez Gil, Ana CSIC ORCID ; Pérez, Concepción CSIC ORCID; Martínez-González, Loreto CSIC ORCID ; Paglione, Maria; Di Schiavi, Elia; Seghetti, Francesca; Tarozzi, Andrea; Belluti, Federicaartículo
14embargoedAccess5-abr-2024Prenylated flavanone isolated from Dalea species as a potential multitarget-neuroprotector in an in vitro Alzheimer’s disease mice modelSanti, Maria D.; Carvalho, Diego; Dapueto, Rosina; Bentura, Manuela; Zeni, Maia; Martínez-González, Loreto CSIC ORCID ; Martínez Gil, Ana CSIC ORCID ; Peralta, Mariana A.; Rey, Ana CSIC ORCID ; Giglio, Javier; Ortega, Maria G.; Savio, E.; Abin-Carriquiri, A.; Arredondo, Florenciaartículo
15openAccessMolecular Neurobiology_Posa et al_2018 .pdf.jpg20-jul-2018Recapitulation of pathological TDP-43 features in immortalized lymphocytes from sporadic ALS patientsPosa, Diana; Martínez-González, Loreto CSIC ORCID ; Bartolomé Robledo, Fernando CSIC ORCID; Siranjeevi, Nagaraj; Porras, Gracia CSIC ; Martínez Gil, Ana CSIC ORCID ; Martín-Requero, Ángeles CSIC ORCID artículo
16openAccess15-ene-2021Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosisRojas-Prats, Elisa CSIC ORCID; Martínez-González, Loreto CSIC ORCID ; Gonzalo-Consuegra, Claudia; Liachko, Nicole F.; Pérez, Concepción CSIC ORCID; Ramírez, David; Kraemer, Brian C.; Martín-Requero, Ángeles CSIC ORCID ; Pérez, Daniel I. CSIC ORCID; Gil, Carmen CSIC ORCID ; De Lago, E.; Martínez Gil, Ana CSIC ORCID artículo
17closedAccessaccesoRestringido.pdf.jpg2018Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation InhibitorsGandini, A.; Bartolini, M.; Tedesco, D.; Martínez-González, Loreto CSIC ORCID ; Roca, Carlos CSIC ORCID; Campillo, Nuria E. CSIC ORCID ; Zaldívar-Díez, Josefa CSIC ORCID; Pérez, Concepción CSIC ORCID; Zuccheri, G.; Miti, Andrea; Feoli, A.; Castellano, S.; Petralla, Sabrina; Monti, B.; Rossi, M.; Moda, F.; Legname, G.; Martínez Gil, Ana CSIC ORCID ; Bolognesi, Maria Lauraartículo
18openAccess3-ene-2022TDP-43 modulation by Tau-Tubulin kinase 1 inhibitors: A new avenue for future amyotrophic lateral sclerosis therapyNozal, Vanesa CSIC ORCID; Martínez-González, Loreto CSIC ORCID ; Gómez-Almería, Marta; Gonzalo-Consuegra, Claudia; Santana, Paula; Chaikuad, Apirat; Cuevas, Eva P. CSIC ORCID ; Knapp, Stefan; Lietha, Daniel CSIC ORCID ; Ramírez, David; Petralla, Sabrina; Monti, B.; Gil, Carmen CSIC ORCID ; Martín-Requero, Ángeles CSIC ORCID ; Palomo, Valle CSIC ORCID ; De Lago, E.; Martínez Gil, Ana CSIC ORCID artículo
19openAccessJournal of Neurochemistry_Vaca et al postprint 2020.pdf.jpg17-jul-2020Therapeutic potential of novel cell division cycle kinase 7 inhibitors on TDP-43-related pathogenesis such as frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS)Vaca, Gabriela; Martínez-González, Loreto CSIC ORCID ; Fernández, Ana; Rojas-Prats, Elisa CSIC ORCID; Porras, Gracia CSIC ; Cuevas, Eva P. CSIC ORCID ; Gil, Carmen CSIC ORCID ; Martínez Gil, Ana CSIC ORCID ; Martín-Requero, Ángeles CSIC ORCID artículo
20openAccessijms_martínez-gonzález_2021.pdf.jpg20-ago-2021Tideglusib, a non-ATP competitive inhibitor of GSK-3β as a drug candidate for the treatment of amyotrophic lateral sclerosisMartínez-González, Loreto CSIC ORCID ; Gonzalo-Consuegra, Claudia; Gómez-Almería, Marta; Porras, Gracia CSIC ; De Lago, E.; Martín-Requero, Ángeles CSIC ORCID ; Martínez Gil, Ana CSIC ORCID artículo