Estructura de Ensamblados Macromoleculares / Structure of Macromolecular Assemblies
Nombre/Name
Estructura de Ensamblados Macromoleculares / Structure of Macromolecular Assemblies
Fecha de inicio/Start Year
01-01-2011
Instituto/Institute
CSIC - Centro de Investigaciones Biológicas Margarita Salas (CIB)
Departamento/Department
Biología Estructural y Química / Structural and Chemical Biology
Línea de Investigación/Research Line
Aplicaciones clínicas contra enfermedades angiodependientes. Transcripción eucariótica / Clinical applications against angiogenic diseases. Eukaryotic transcription
Especialización principal/Focus Area
A2. Biología y Biomedicina
A2.3 Biología estructural y biofísica
A2.3 Biología estructural y biofísica
Descripción/Description
Los procesos celulares son realizados por macromoléculas, principalmente proteínas y ácidos nucleicos, que actúan de forma aislada o, más comúnmente, asociados en complejos. La naturaleza dinámica de estos complejos hace que su estudio sea difícil, pero conocer cómo funcionan es esencial para comprender las funciones celulares y la base molecular de ciertas enfermedades. En nuestro grupo combinamos la cristalografía de rayos X y la criomicroscopía electrónica para estudiar la estructura tridimensional de las macromoléculas y sus complejos. Esta caracterización estructural estructural se complementa con otras técnicas biofísicas y bioquímicas. Nuestros estudios ayudan a entender cómo las macromoléculas catalizan importantes procesos celulares y abren la puerta al desarrollo de fármacos contra diversas enfermedades
Cellular processes are carried out by macromolecules, mainly proteins and nucleic acids, that act in isolation or, more commonly, associated in macromolecular complexes. The dynamic nature of these complexes makes their study difficult, but learning how they work is critical to understand cellular function and the basis of certain diseases. In our group, we combine X-ray crystallography and electron microscopy to study the three-dimensional structure of macromolecules and their complexes. This structural characterization is complemented with other biochemical and biophysical techniques. Our studies help to understand how nanoscale machines perform important cellular processes, and open avenues for the development of drugs against various diseases.
Web: Estructura de Ensamblados Macromoleculares
Cellular processes are carried out by macromolecules, mainly proteins and nucleic acids, that act in isolation or, more commonly, associated in macromolecular complexes. The dynamic nature of these complexes makes their study difficult, but learning how they work is critical to understand cellular function and the basis of certain diseases. In our group, we combine X-ray crystallography and electron microscopy to study the three-dimensional structure of macromolecules and their complexes. This structural characterization is complemented with other biochemical and biophysical techniques. Our studies help to understand how nanoscale machines perform important cellular processes, and open avenues for the development of drugs against various diseases.
Web: Estructura de Ensamblados Macromoleculares