Modificación Postraduccional de Proteínas / Posttranslational modification of proteins
Nombre/Name
Modificación Postraduccional de Proteínas / Posttranslational modification of proteins
Fecha de inicio/Start Year
01/07/2003
Instituto/Institute
CSIC - Centro de Investigaciones Biológicas Margarita Salas (CIB)
Departamento/Department
Biología Estructural y Química / Structural and Chemical Biology
Línea de Investigación/Research Line
Modificación de proteínas por lípidos electrófilos: estudios de estructura-función e identificación de nuevas dianas.
Protein modification by electrophilic lipids: structure-activity studies and identification of novel targets. Intermediate filaments
Protein modification by electrophilic lipids: structure-activity studies and identification of novel targets. Intermediate filaments
Especialización principal/Focus Area
A2. Biología y Biomedicina
A2.3 Biología estructural y biofísica
A2.3 Biología estructural y biofísica
Descripción/Description
La modificación postraduccional de proteínas es un mecanismo clave para su regulación por numerosos mediadores endógenos, toxinas y fármacos. Nuestro grupo estudia la modificación de proteínas por lípidos y especies reactivas y su caracterización estructural y funcional. Abordamos la importancia de las modificaciones postraduccionales en procesos biológicos esenciales y en condiciones fisiopatológicas, así como su papel en el mecanismo de acción de fármacos. Nuestro grupo ha identificado nuevas funciones de la isoprenilación y palmitoilación de proteínas, nuevas dianas de prostaglandinas ciclopentenonas con interés terapéutico, y ha desvelado la importancia de algunas de estas dianas en procesos biológicos básicos como el tráfico intracelular o la mitosis. Nuestros hallazgos se han traducido en publicaciones, patentes y Tesis. El grupo lleva a cabo una intensa actividad formativa y mantiene numerosas colaboraciones nacionales (RETIC) e internacionales (ITN H2020, COST Actions).
The posttranslational modification of proteins is a key mechanism for the regulation of their activity by biological mediators, including lipids and reactive species, drugs and toxins. We are interested in the structural and functional characterization of novel types of posttranslational modifications, the identification of their protein targets, and the study of their role in essential biological processes, molecular pathophysiology and drug action. Our group has identified novel roles of protein isoprenylation and palmitoylation and novel targets of cyclopentenone prostaglandins with therapeutic interest. We have also unveiled novel roles in basic biological processes such as intracellular traffic and cell division. These activities have yielded publications, PhD Thesis and patents. We participate in national (RETIC) and international collaborations (ITN H2020, COST Actions)
Web: Modificación postraduccional de proteínas
The posttranslational modification of proteins is a key mechanism for the regulation of their activity by biological mediators, including lipids and reactive species, drugs and toxins. We are interested in the structural and functional characterization of novel types of posttranslational modifications, the identification of their protein targets, and the study of their role in essential biological processes, molecular pathophysiology and drug action. Our group has identified novel roles of protein isoprenylation and palmitoylation and novel targets of cyclopentenone prostaglandins with therapeutic interest. We have also unveiled novel roles in basic biological processes such as intracellular traffic and cell division. These activities have yielded publications, PhD Thesis and patents. We participate in national (RETIC) and international collaborations (ITN H2020, COST Actions)
Web: Modificación postraduccional de proteínas