Biología celular y molecular del endotelio vascular / Cellular and molecular biology of the vascular endothelium
Nombre/Name:
Biología celular y molecular del endotelio vascular / Cellular and molecular biology of the vascular endothelium
Instituto/Institute:
CSIC - Centro de Investigaciones Biológicas Margarita Salas (CIB)
Departamento/Department:
Biomedicina Molecular / Molecular Biomedicine
Línea de Investigación/Research Line:
Endoglina, un receptor endotelial implicado en la patología vascular / Endoglin, an endothelial receptor involved in vascular pathology
Especialización principal/Focus Area:
sin información
Descripción/Description:
[ES] Endoglina y ALK1 son miembros del complejo receptor de TGF-beta en células endoteliales con implicaciones en la fisiopatología vascular. Mutaciones en los genes de endoglina o ALK1 (ACVRL1) son responsables de la Telangiectasia Hemorrágica Hereditaria (HHT), una enfermedad vascular autosómica dominante. Endoglina y ALK1 regulan la angiogénesis y homeostasis vascular, y una forma soluble de endoglina tiene un papel patogénico en preeclampsia
[EN ] Endoglin and ALK1 are components of the TGF-beta receptor complex in endothelial cells that are involved in vascular physiopathology. Mutations in endoglin or ALK1 (ACVRL1) genes give rise to the Hereditary Hemorrhagic Telangiectasia (HHT), a dominant autosomic vascular dysplasia. Endoglin and ALK1 regulate angiogenesis and vascular homeostasis, and a soluble form of endoglin has a pathogenic role in preeclampsia.
Web: Biología celular y molecular del endotelio vascular
[EN ] Endoglin and ALK1 are components of the TGF-beta receptor complex in endothelial cells that are involved in vascular physiopathology. Mutations in endoglin or ALK1 (ACVRL1) genes give rise to the Hereditary Hemorrhagic Telangiectasia (HHT), a dominant autosomic vascular dysplasia. Endoglin and ALK1 regulate angiogenesis and vascular homeostasis, and a soluble form of endoglin has a pathogenic role in preeclampsia.
Web: Biología celular y molecular del endotelio vascular