Biología Molecular de la Gametogénesis / Molecular Biology of Gametogenesis
Nombre/Name
Biología Molecular de la Gametogénesis / Molecular Biology of Gametogenesis
Fecha de inicio/Start Year
16/03/1981
Instituto/Institute
CSIC - Centro de Investigaciones Biológicas Margarita Salas (CIB)
Departamento/Department
Biología Celular y Molecular / Cellular and Molecular Biology
Línea de Investigación/Research Line
Expresión y regulación génica en la gametogenesis de mamíferos. Proteómica en espermatogénesis. Reprotoxicidad, desregulación genica e infertilidad masculina / Gene expression and regulation in mammalian gametogenesisHead. Proteomic studies in spermatogenesis. Reprotoxicity, gene deregulation, and male infertility
Especialización principal/Focus Area
A2. Biología y Biomedicina
A2.1 Biología celular y del desarrollo
A2.1 Biología celular y del desarrollo
Descripción/Description
[ES] El complejo control de la diferenciación celular terminal para generar gametos esta mediado por regulación de la expresión génica que interacciona con múltiples factores endocrinos paracrinos y autocrinos. Nuestro laboratorio está enfocado en la caracterización de mecanismos moleculares que, a través de expresión génica, tanto de mRNAs como sRNAs (small RNAs), controlan la diferenciación y desarrollo de ovocitos y espermatozoides y primeras etapas postzigóticas. Nuestro grupo estudia el papel y regulación de genes implicados tanto en la gametogenesis en ambos sexos y su contribución al desarrollo cigótico preimplantacional y como su desregulación puede ser potencialmente responsable de alteraciones en la fertilidad, incluidos los ocasionados por exposición a contaminantes ambientales del tipo de los denominados disruptores endocrinos.
[EN] The complex control of terminal cell differentiation producing gametes is mediated by regulation of gene expression interacting with multiple endocrine, paracrine and autocrine factors. Our laboratory is focused on the characterization of molecular mechanisms, through gene expression of both mRNAs as sRNAs (small RNAs), wich control the differentiation and development of oocytes and sperm as well as the early embryos. Our currently study the role and regulation of genes involved in gametogenesis in both sexes and their contribution to zygotic preimplantation development. We also assess how their deregulation may be potentially responsible for impaired fertility induced by exposure to environmental pollutants including those considered as “endocrine disruptors”.
Web: Biología Molecular de la Gametogénesis
[EN] The complex control of terminal cell differentiation producing gametes is mediated by regulation of gene expression interacting with multiple endocrine, paracrine and autocrine factors. Our laboratory is focused on the characterization of molecular mechanisms, through gene expression of both mRNAs as sRNAs (small RNAs), wich control the differentiation and development of oocytes and sperm as well as the early embryos. Our currently study the role and regulation of genes involved in gametogenesis in both sexes and their contribution to zygotic preimplantation development. We also assess how their deregulation may be potentially responsible for impaired fertility induced by exposure to environmental pollutants including those considered as “endocrine disruptors”.
Web: Biología Molecular de la Gametogénesis