Reconocimiento Célula-Biomaterial / Cell-Biomaterial Recognition
Nombre/Name
Reconocimiento Célula-Biomaterial / Cell-Biomaterial Recognition
Fecha de inicio/Start Year
01/01/2008
Instituto/Institute
CSIC - Centro de Investigaciones Biológicas Margarita Salas (CIB)
Departamento/Department
Biología Celular y Molecular / Cellular and Molecular Biology
Línea de Investigación/Research Line
Respuesta celular a los productos de desgaste, partículas e iones metálicos, derivados del proceso de desgaste-corrosión de aleaciones cobalto-cromo con alto contenido en carbono. Respuesta celular a materiales biodegradables de base magnesio. Biocompatibilidad y respuesta inflamatoria implicada en la osteolisis periprotésica de nuevos materiales metálicos con lubricantes sólidos. Diseño de nuevas superficies biomiméticas sobre materiales para su aplicación en reparación ósea / Cell response to wear debris particles and ions derived from wear-corrosion process of cobalt-chromium alloys with high carbon content. Cell response to biodegradable magnesium-based materials. Biocompatibility and inflammatory response involved in periprosthesic osteolysis of new metallic materials with solid lubricants. Biomimetic surfaces design of new materials for bone repair applications
Especialización principal/Focus Area
A2. Biología y Biomedicina
A2.1 Biología celular y del desarrollo
A2.1 Biología celular y del desarrollo
Descripción/Description
[ES] El grupo de investigación "Reconocimiento Célula-Biomaterial" está interesado en caracterizar la interacción de biomateriales con las células que se encuentran en el entorno en del material implantado en condiciones experimentales que simulan las condiciones fisiológicas. La investigación se centra fundamentalmente en el estudio de dos tipos de biomateriales para su aplicación en reparación ósea, como son ciertos materiales metálicos y cerámicos. En concreto, entre los materiales metálicos estudiamos aleaciones de Cobalto-Cromo con alto contenido en carbono para su aplicación como prótesis de cadera y materiales biodegradables de base Magnesio y, entre los cerámicos, las hidroxiapatitas sustituidas con silicio en las que unen factores de crecimiento para favorecer la reparación ósea. Las respuestas celulares que se desencadenan como consecuencia de la interacción con los biomateriales en estudio proporcionan información útil que permite conocer la posible aplicabilidad del material.
[EN] The Cell-Biomaterial Recognition group is mainly focus in the study of the interaction of biomaterials within the specific cells that appear in the tissue where the material will be implanted. Special care is taken in the use of experimental assays that mimicked closely the physiological conditions that take place in the tissue. Two different materials are in study for its application in bone tissue repair, as are the case of certain metallic and ceramic materials. Among the metallics, special attention is paid to cobalt-chromium alloys with high-carbon content for its application for hip replacement and to magnesium-based biodegradable materials. Among the ceramic materials, some silicon substituted hydroxyapatites are under study as material to immobilize growth factors for improving the response of the ceramic for bone regeneration. The cell response to materials under study will provide important and useful information to know the potential applicability of the material
Web: Reconocimiento Célula-Biomaterial
[EN] The Cell-Biomaterial Recognition group is mainly focus in the study of the interaction of biomaterials within the specific cells that appear in the tissue where the material will be implanted. Special care is taken in the use of experimental assays that mimicked closely the physiological conditions that take place in the tissue. Two different materials are in study for its application in bone tissue repair, as are the case of certain metallic and ceramic materials. Among the metallics, special attention is paid to cobalt-chromium alloys with high-carbon content for its application for hip replacement and to magnesium-based biodegradable materials. Among the ceramic materials, some silicon substituted hydroxyapatites are under study as material to immobilize growth factors for improving the response of the ceramic for bone regeneration. The cell response to materials under study will provide important and useful information to know the potential applicability of the material
Web: Reconocimiento Célula-Biomaterial