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Browsing by Author Steinmetz, Michel O.

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Showing results 1 to 16 of 16
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openAccessNature Communications_Menchon_2018.pdf.jpg29-May-2018A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulinMenchon, Grégory; Lucena-Agell, Daniel CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Steinmetz, Michel O.artículo
openAccessOncotarget.pdf.jpg20-May-2016Antivascular and antitumor properties of the tubulin-binding chalcone TUB091Canela, María-Dolores CSIC; Noppen, Sam; Bueno, Oskía; Prota, Andrea E.; Bargsten, Katja; Sáez-Calvo, Gonzalo; Jimeno, M. Luisa CSIC ORCID; Benkhei, Mohammed; Ribatti, Domenico; Velázquez, Sonsoles CSIC ORCID CVN; Camarasa Rius, María José CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Steinmetz, Michel O.; Priego, Eva María CSIC ORCID; Peréz-Pérez, María-Jesús CSIC ORCID ; Liekens, Sandraartículo
openAccessijms-20-01392.pdf.jpg20-Mar-2019Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site LigandsBalaguer, Francisco de Asís; Mühlethaler, Tobias; Estévez-Gallego, Juan CSIC ORCID ; Calvo, Enrique; Giménez-Abián, Juan F. CSIC ; Risinger, April L.; Sorensen, Erik J.; Vanderwal, Christopher D.; Altmann, Karl-Heinz; Mooberry, Susan; Steinmetz, Michel O.; Oliva, María A. CSIC ORCID ; Prota, Andrea E.; Díaz, José Fernando CSIC ORCID artículo
openAccessScientific reports(2018)4242.pdf.jpg2018High-affinity ligands of the colchicine domain in tubulin based on a structure-guided designBueno, Oskía; Estévez-Gallego, Juan CSIC ORCID ; Martins, S.; Prota, Andrea E.; Gago, Federico CSIC ORCID; Gómez-SanJuan, Asier; Camarasa Rius, María José CSIC ORCID; Barasoain, Isabel CSIC ; Steinmetz, Michel O.; Díaz, Fernando J.; Peréz-Pérez, María-Jesús CSIC ORCID ; Liekens, Sandra; Priego, Eva María CSIC ORCIDartículo
closedAccessrestringido.pdf.jpg1-Feb-2013Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer AgentsProta, Andrea E.; Bargsten, Katja; Zurwerra, Didier; Field, Jessica J.; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinz; Steinmetz, Michel O.artículo
openAccessJMB-D-16-.pdf.jpg31-Jul-2016Pironetin binds covalently to Cys316 and perturbs a major loop and helix of -tubulin to inhibit microtubule formationProta, Andrea E.; Setter, J.; Waight, Andrew B.; Bargsten, Katja; Murga, Juan; Díaz, José Fernando CSIC ORCID ; Steinmetz, Michel O.artículo
openAccessProtein ligand complex.pdf.jpg23-Jan-2018Protein-ligand complex for structure-based design: impact on the affinity and antitumor activity of new tubulin ligandsBueno, Oskía; Estévez-Gallego, Juan CSIC ORCID ; Martins, S.; Prota, Andrea E.; Gago, Federico CSIC ORCID; Gómez-SanJuan, Asier; Camarasa Rius, María José CSIC ORCID; Barasoain, Isabel CSIC ; Steinmetz, Michel O.; Díaz, José Fernando CSIC ORCID ; Liekens, Sandra; Peréz-Pérez, María-Jesús CSIC ORCID ; Priego, Eva María CSIC ORCIDcomunicación de congreso
openAccessijms-18-01336.pdf.jpg22-Jun-2017Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulinSharma, Ashwani; Sáez-Calvo, Gonzalo; Olieric, Natacha; Balaguer, Francisco de Asís; Barasoain, Isabel CSIC ; Lamberth, Clemens; Díaz, José Fernando CSIC ORCID ; Steinmetz, Michel O.artículo
closedAccessaccesoRestringido.pdf.jpg2012Sequence determinants of a microtubule tip localization signal (MtLS)Martínez Buey, Rubén CSIC ORCID CVN; Pereda, José M. de ; Steinmetz, Michel O.artículo
openAccessiscience_Cury_2019.pdf.jpg22-Nov-2019Structural basis of colchicine-site targeting acylhydrazones active against multidrug-resistant acute lymphoblastic leukemiaCury, Nathália Moreno; Mühlethaler, Tobias; Laranjeira, Angelo Brunelli Albertoni; Canevarolo, Rafael Renatino; Zenatti, Priscila Pini; Lucena-Agell, Daniel CSIC ORCID ; Barasoain, Isabel CSIC ; Song, Chunhua; Sun,Dongxiao; Dovat, Sinisa; Yunes, Rosendo Augusto; Prota, Andrea E.; Steinmetz, Michel O.; Díaz, José Fernando CSIC ORCID ; Yunes, José Andrésartículo
openAccesschembiochem_prota_2017.pdf.jpg16-Feb-2017Structural basis of microtubule stabilization by discodermolideProta, Andrea E.; Bargsten, Katja; Redondo-Horcajo, Mariano CSIC ORCID ; Smith III, Amos B.; Yang, Chia-Ping H.; McDaid, Hayley M.; Paterson, Ian; Horwitz, Susan; Díaz, José Fernando CSIC ORCID ; Steinmetz, Michel O.artículo
openAccessacs.jmedchem_Oliva_2020.pdf.jpg13-Jul-2020Structural basis of noscapine activation for tubulin bindingOliva, María A. CSIC ORCID ; Prota, Andrea E.; Rodríguez-Salarichs, Javier; Wenxin, Gu; Bennani, Y. L.; Jiménez-Barbero, Jesús CSIC ORCID; Bargsten, Katja; Canales, Ángeles CSIC ORCID; Steinmetz, Michel O.; Díaz, José Fernando CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg13-Dec-2016Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer CellsTrigili, Chiara CSIC; Barasoain, Isabel CSIC ; Sánchez-Murcia, Pedro A. CSIC ORCID; Bargsten, Katja; Redondo-Horcajo, Mariano CSIC ORCID ; Nogales, Aurora CSIC ORCID; Gardner, Nicola M.; Meyer, Arndt; Naylor, Guy J.; Gomez-Rubio, Elena; Gago, Federico CSIC ORCID; Steinmetz, Michel O.; Paterson, Ian; Prota, Andrea E.; Díaz, José Fernando CSIC ORCID artículo
openAccesselife-Estévez-Gallego-2020.pdf.jpg10-Mar-2020Structural model for differential cap maturation at growing microtubule endsEstévez-Gallego, Juan CSIC ORCID ; Josa-Prado, Fernando; Ku, Siou; Martínez Buey, Rubén CSIC ORCID CVN; Balaguer, Francisco de Asís; Prota, Andrea E.; Lucena-Agell, Daniel CSIC ORCID ; Kamma-Lorger, C.S.; Yagi, Toshiki; Iwamoto, Hiroyuki; Duchesne, Laurence; Barasoain, Isabel CSIC ; Steinmetz, Michel O.; Chrétien, Denis; Kamimura, Shinji; Díaz, José Fernando CSIC ORCID ; Oliva, María A. CSIC ORCID artículo
openAccess14-Nov-2019Structure, Thermodynamics, and Kinetics of Plinabulin Binding to Two Tubulin IsotypesLa Sala, Giuseppina; Olieric, Natacha; Sharma, Ashwani; Viti, Federica; Balaguer, Francisco de Asís; Huang, Lan; Tonra, James R.; Lloyd, George Kenneth; Decherchi, Sergio; Díaz, José Fernando CSIC ORCID ; Steinmetz, Michel O.; Cavalli, Andreaartículo
closedAccessaccesoRestringido.pdf.jpg15-Jan-2019Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agentsBrindisi, Margherita; Ulivieri, Cristina; Alfano, Gloria; Gemma, Sandra; Balaguer, Francisco de Asís; Khan, Tuhina; Grillo, Alessandro; Chemi, Giulia; Menchon, Grégory; Prota, Andrea E.; Olieric, Natacha; Lucena-Agell, Daniel CSIC ORCID ; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID ; Nebbioso, Angela; Conte, Mariarosaria; Lopresti, Ludovica; Magnano, Stefania; Amet, Rebecca; Kinsella, Paula; Zisterer, Daniela M.; Ibrahim, Ola; O'Sullivan, Jeff; Morbidelli, Lucia; Spaccapelo, Roberta; Baldari, Cosima T.; Butini, Stefania; Novellino, Ettore; Campiani, Giuseppe; Altucci, Lucia; Steinmetz, Michel O.; Brogi, Simoneartículo