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closedAccessaccesoRestringido.pdf.jpgAug-20181,2-Diphenoxiethane salts as potent antiplasmodial agentsSchiafino-Ortega, Santiago; Baglioni, Eleonora; Pérez-Moreno, Guiomar; Ríos Marco, Pablo; Marco, Carmen; González-Pacanowska, D.; Ruiz-Pérez, Luis Miguel; Carrasco-Jiménez, Maria Paz; López-Cara, Luisa C.artículo
closedAccessaccesoRestringido.pdf.jpg2021A Mitochondrial Orthologue of the dNTP Triphosphohydrolase SAMHD1 Is Essential and Controls Pyrimidine Homeostasis in Trypanosoma bruceiYagüe Capilla, M; Castillo-Acosta, VM; Bosch-Navarrete, Cristina; Ruiz-Pérez, Luis Miguel; González-Pacanowska, D.artículo
openAccess4-Jul-2018A role for the human nucleotidohydrolase DCTPP1 in pyrimidine nucleotide homeostasis and genetic integrityMartínez-Arribas, B.; Ruiz-Pérez, Luis Miguel; Vidal, Antonio E.; González-Pacanowska, D.actas de congreso
closedAccessaccesoRestringido.pdf.jpg13-Feb-2019A role for the human nucleotidohydrolase DCTPP1 in pyrimidine nucleotide homeostasis and genetic integrityMartínez-Arribas, B.; Ruiz-Pérez, Luis Miguel; Vidal, A.E.; González-Pacanowska, D.comunicación de congreso
closedAccessaccesoRestringido.pdf.jpg2011Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compoundsOlmo, Esther del; Barboza, B.; Chiaradia, L. D.; Moreno, A.; Carrero-Lérida, J.; González-Pacanowska, D.; Muñoz, V.; López-Pérez, J. L.; Giménez, Alberto P.; Benito, Agustín; Martínez, A. R.; Ruiz-Pérez, Luis Miguel; San Feliciano, A.artículo
closedAccessaccesoRestringido.pdf.jpg2018Antiprotozoan sesterterpenes and triterpenes isolated from two Ghanaian mushroomsAnnang, Frederick; Pérez-Victoria, Ignacio; Appiah, Theresa; Pérez-Moreno, Guiomar; Domingo, E; Martín, Jesús; Mackenzie, Thomas; Ruiz-Pérez, Luis Miguel; González-Pacanowska, D.; Genilloud, Olga; Vicente, Francisca; Agyare, Christian; Reyes, Fernandoartículo
closedAccessaccesoRestringido.pdf.jpg1-Feb-2019Base excision repair plays an important role in the protection against nitric oxide- and in vivo-induced DNA damage in Trypanosoma bruceiYague-Capilla, Miriam; García-Caballero, Daniel; Aguilar-Pereyra, Fernando; Castillo Acosta, Víctor M.; Ruiz-Pérez, Luis Miguel; Vidal, Antonio E.; González-Pacanowska, D.artículo
openAccessCarbohydrate_Binding_Plos_Pathogens_2016.pdf.jpg23-Sep-2016Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine ModelsCastillo Acosta, Víctor M.; Ruiz-Pérez, Luis Miguel; Etxebarria, Juan; Reichardt, Niels Christian; Navarro, M.; Igarashi, Yasuhiro; Liekens, Sandra; Balzarini, Jan; González-Pacanowska, D.artículo
openAccess2019Contribution of Cytidine Deaminase to Thymidylate Biosynthesis in Trypanosoma brucei: Intracellular Localization and Properties of the EnzymeMoro-Bulnes, Ana; Castillo-Acosta, Victor M.; Valente, María; Carrero-Lérida, Juana; Pérez-Moreno, Guiomar; Ruiz-Pérez, Luis Miguel; González-Pacanowska, D.artículo
openAccess13-Feb-2019Cytidine deaminase in Trypanosoma brucei: A mitochondrial enzyme involved in >de novo> biosyntesis of pyrimidinesMoro Bulnes, A; Pérez Moreno, G; Castillo Acosta, Víctor M.; Valente, M; Ruiz-Pérez, Luis Miguel; González-Pacanowska, D.comunicación de congreso
openAccess8-Apr-2018Cytidine deaminase in Trypanosoma brucei: a mitochondrial enzyme involved in de novo biosynthesis of pyrimidinesMoro Bulnes, A; Pérez-Moreno, Guiomar; Castillo-Acosta, VM; Ruiz-Pérez, Luis Miguel; Gonzalez-Pacanowska, D.actas de congreso
openAccess12-Jun-2019DCTPP1 preserves genomic integrity through the modulation of dCTP and dTTP homeostasisMartínez-Arribas, B; Ruiz-Pérez, Luis Miguel; Vidal, Antonio E.; González-Pacanowska, D.comunicación de congreso
openAccess12-Jun-2019Deciphering the role of HD52, a mitochondrial nucleotidase essential for pyrimidine homeostasis in Trypanosoma bruceiYagüe-Capilla, M; Castillo-Acosta, VM; Valente, M; Bosch-Navarrete, Cristina; Ruiz-Pérez, Luis Miguel; González-Pacanowska, D.comunicación de congreso
openAccessjournal.pone.0145812.PDF.jpg6-Jan-2016Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural ProductsPérez-Moreno, Guiomar; Cantizani, Juan; Sánchez-Carrasco, Paula; Ruiz-Pérez, Luis Miguel; Martín, Jesús; El Aouad, Noureddine; Pérez-Victoria, Ignacio; Tormo, José Rubén; González-Menendez, Víctor; González, Ignacio; de Pedro, Nuria; Reyes, Fernando; Genilloud, Olga; Vicente, Francisca; González-Pacanowska, D.artículo
openAccessKlug-2019-Evaluation-of-a-class-of-isatinoids.pdf.jpg8-Feb-2019Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agentsKlug, Dana M.; Díaz-González, Rosario; Pérez-Moreno, Guiomar; Ceballos-Pérez, Gloria; García-Hernández, Raquel; Gómez-Pérez, Veronica; Ruiz-Pérez, Luis Miguel; Rojas-Barros, Domingo I.; Gamarro, Francisco; González-Pacanowska, D.; Martínez-Martínez, María S.; Manzano, Pilar; Ferrins, Lori; Caffrey, Conor R.; Navarro, M.; Pollastri, M.P.artículo
openAccessExposure_pntd.PDF.jpg6-Mar-2015Exposure of Trypanosoma brucei to an N-acetylglucosamine-Binding Lectin Induces VSG Switching and Glycosylation Defects Resulting in Reduced InfectivityCastillo Acosta, Víctor M.; Ruiz-Pérez, Luis Miguel; Van Damme, Els J. M.; Balzarini, Jan; González-Pacanowska, D.artículo
openAccess8-Nov-2020Hit-to lead and target identification studies within a novel class of anti-trypanosomal agentsFerrins, L; Díaz González, R.; Ceballos-Pérez, G.; Saura, A.; Pérez-Moreno, G; García-Hernández, R; Bosch-Navarrete, Cristina; Gamarro, Francisco; Ruiz-Pérez, Luis Miguel; González-Pacanowska, D.; Navarro, M.; Pollastri, M.actas de congreso
openAccess8-Mar-2020Hit-to-lead and target identification studies within a novel class of antitrypanosomal agentsFerrins, L; Díaz-González, Rosario; Ceballos-Pérez, Gloria; Saura, A.; Pérez-Moreno, Guiomar; García-Hernández, R.; Boch-Navarrete, C; Gamarro, Francisco; Ruiz-Pérez, Luis Miguel; González-Pacanowska, D.; Navarro, M.; Pollastri, M.actas de congreso
openAccess8-Mar-2020Identification of SAMHD1 orthologues in Trypanosoma brucei reveals novel features of pyrimidine dNTP homeostasisYagüe Capilla, M; Castillo-Acosta, VM; Valente, M; Boch-Navarrete, C; Ruiz-Pérez, Luis Miguel; Gonzalez-Pacanowska, D.actas de congreso
openAccessInsights_2017.pdf.jpg17-Aug-2017Insights into the role of endonuclease V in RNA metabolism in Trypanosoma bruceiGarcía-Caballero, Daniel; Pérez-Moreno, Guiomar; Estévez, Antonio M.; Ruiz-Pérez, Luis Miguel; Vidal, Antonio E.; González-Pacanowska, D.artículo