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openAccessA Phosphorylation-Induced.pdf.jpg11-Sep-2020A phosphorylation-induced switch in the nuclear localization sequence of the intrinsically disordered NUPR1 hampers binding to importinNeira, José L. CSIC ORCID; Rizzuti, Bruno; Jiménez-Alesanco, Ana CSIC; Palomino-Schätzlein, Martina; Abian, Olga CSIC ORCID; Velázquez-Campoy, Adrián; Iovanna, Juan Lucioartículo
closedAccessaccesoRestringido.pdf.jpg2018Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1)Santofimia-Castaño, P.; Rizzuti, Bruno; Abian, Olga CSIC ORCID; Velázquez-Campoy, Adrián; Iovanna, Juan Lucio; Neira, J.L.artículo
openAccessCrowding Effects.pdf.jpg5-Jul-2021Crowding Effects on the Structure and Dynamics of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1Bonucci, Alessio; Palomino-Schätzlein, Martina; Malo de Molina, Paula CSIC ORCID; Arbe, Arantxa CSIC ORCID; Pierattelli, Roberta; Rizzuti, Bruno; Iovanna, Juan Lucio; Neira, José L. CSIC ORCIDartículo
openAccessintrinsically_disordered_proteins.pdf.jpg3-Oct-2021Design of inhibitors of the intrinsically disordered protein NUPR1: balance between drug affinity and target functionRizzuti, Bruno; Lan, Wenjun; Santofimia-Castaño, Patricia; Zhou, Zhengwei; Velázquez-Campoy, Adrián; Abian, Olga CSIC ORCID; Peng, Ling; Neira, José L. CSIC ORCID; Xia, Yi; Iovanna, Juan Lucioartículo
openAccessintrinsically_disordered_proteins.pdf.jpg16-May-2019Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigmSantofimia-Castaño, Patricia; Rizzuti, Bruno; Xia, Yi; Abian, Olga CSIC ORCID; Peng, Ling; Velázquez-Campoy, Adrián; Iovanna, Juan Lucio; Neira, José L. CSIC ORCIDartículo
openAccess2020Dynamics of the intrinsically disordered inhibitor IF7 of glutamine synthetase in isolation and in complex with its partnerNeira, José L. CSIC ORCID; Ortore, M.G.; Florencio, Francisco J.; Muro-Pastor, M. Isabel CSIC ORCID ; Rizzuti, Brunoartículo
closedAccessaccesoRestringido.pdf.jpg17-Jul-2019Dynamics of the intrinsically disordered protein NUPR1 in isolation and in its fuzzy complexes with DNA and prothymosin αNeira, José L. CSIC ORCID; Palomino-Schätzlein, M.; Ricci, C.; Ortore, M.G.; Rizzuti, Bruno; Iovanna, Juan Lucioartículo
closedAccessaccesoRestringido.pdf.jpg2020Human importin α3 and its N-terminal truncated form, without the importin-β-binding domain, are oligomeric species with a low conformational stability in solutionDíaz-García, Clara; Hornos, Felipe; Giudici, A. Marcela; Cámara-Artigas, Ana; Luque-Ortega, Juan Román CSIC ORCID ; Arbe, Arantxa CSIC ORCID; Rizzuti, Bruno; Alfonso, Carlos CSIC ORCID ; Forwood, Jade K.; Iovanna, Juan Lucio; Gómez, Javier; Prieto, Manuel CSIC; Coutinho, Ana; Neira, José L. CSIC ORCIDartículo
openAccesssrep39732.pdf.jpg2017Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic AdenocarcinomaNeira, J.L.; Bintz, J.; Arruebo, María; Rizzuti, Bruno; Bonacci, T.; Vega, Sonia CSIC ORCID; Lanas, A.; Velázquez-Campoy, Adrián; Iovanna, Juan Lucio; Abian, Olga CSIC ORCIDartículo
openAccessPNAS-2017-Santofimia-Castaño-E6332-41.pdf.jpg18-Jul-2017Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1BSantofimia-Castaño, Patricia; Rizzuti, Bruno; Pey, Ángel L.; Soubeyran, Philippe; Vidal, Miguel CSIC ORCID ; Urrutia, Raúl; Iovanna, Juan Lucio; Neira, José L. CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpgJun-2017Intrinsically disordered inhibitor of glutamine synthetase is a functional protein with random-coil-like pKa valuesCozza, Concetta; Neira, José L. CSIC ORCID; Florencio, Francisco J.; Muro-Pastor, M. Isabel CSIC ORCID ; Rizzuti, Brunoartículo
openAccessNUPR1.pdf.jpg28-Mar-2019Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosisSantofimia-Castaño, Patricia; Xia, Yi; Lan, Wenjun; Zhou, Zhengwei; Huang, Can; Peng, Ling; Soubeyran, Philippe; Velázquez-Campoy, Adrián; Abian, Olga CSIC ORCID; Rizzuti, Bruno; Neira, José L. CSIC ORCID; Iovanna, Juan Lucioartículo
openAccessProteinScience_2023_Araujo‐Abad_New insights.pdf.jpgAug-2023New insights into cancer: MDM2 binds to the citrullinating enzyme PADI4Araujo-Abad, Salomé; Rizzuti, Bruno; Villamarin-Ortiz, Adrián; Pantoja-Uceda, D.; Moreno-Gonzalez, Celia M; Abian, Olga CSIC ORCID; Velazquez-Campoy, Adrián; Neira, José L. CSIC ORCID; de Juan Romero, Caminoartículo
openAccessPolyphenols from Citrus Tacle.pdf.jpg21-Sep-2021Polyphenols from citrus tacle® extract endowed with hmgcr inhibitory activity: An antihypercholesterolemia natural remedyGrande, Fedora; Occhiuzzi, María Antonietta; Perri, Maria Rosaria; Ioele, Giuseppina; Rizzuti, Bruno; Statti, Giancarlo; Garofalo, Antonioartículo
openAccessResidual Helicity.pdf.jpg6-Oct-2021Residual helicity at the active site of the histidine phosphocarrier, HPr, modulates binding affinity to its natural partnersNeira, José L. CSIC ORCID; Ortega-Alarcón, David; Rizzuti, Bruno; Palomino-Schätzlein, M.; Velázquez-Campoy, Adrián; Falcó, Albertoartículo
openAccessbiomedicines-09-00375.pdf.jpg2-Apr-2021Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin AnalogsRizzuti, Bruno; Grande, Fedora; Conforti, Filomena; Jiménez-Alesanco, Ana CSIC; Ceballos-Laita, Laura CSIC ORCID; Ortega-Alarcón, David; Vega, Sonia CSIC ORCID; Reyburn, H. T. ; Abian, Olga CSIC ORCID; Velázquez-Campoy, Adriánartículo
openAccessijms-22-07048.pdf.jpg30-Jun-2021Seleno-Functionalization of Quercetin Improves the Non-Covalent Inhibition of Mpro and Its Antiviral Activity in Cells against SARS-CoV-2Mangiavacchi, Fancesca; Botwina, Pawel; Menichetti, Elena; Bagnoli, Luana; Rosati, Ornelo; Marini, Francesca; Fonseca, Sergio F.; Abenante, Laura; Alves, Diego; Dabrowska, Agnieszka; Kula-Pacurar, Anna; Ortega-Alarcón, David; Jiménez-Alesanco, Ana CSIC; Ceballos-Laita, Laura CSIC ORCID; Vega, Sonia CSIC ORCID; Rizzuti, Bruno; Abian, Olga CSIC ORCID; Lenardão, Eder J.; Velázquez-Campoy, Adrián; Pyrc, Krzysztof; Sancineto, Luca; Santi, Claudioartículo
openAccessStructural stability_Abian.pdf.jpg1-Aug-2020Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screeningAbian, Olga CSIC ORCID; Ortega-Alarcón, David; Jiménez-Alesanco, Ana CSIC; Ceballos-Laita, Laura CSIC ORCID; Vega, Sonia CSIC ORCID; Reyburn, H. T. ; Rizzuti, Bruno; Velázquez-Campoy, Adriánartículo
openAccesspharmaceuticals-14-00892.pdf.jpg1-Sep-2021Sub-Micromolar Inhibition of SARS-CoV-2 3CLpro by Natural CompoundsRizzuti, Bruno; Ceballos-Laita, Laura CSIC ORCID; Ortega-Alarcón, David; Jiménez-Alesanco, Ana CSIC; Vega, Sonia CSIC ORCID; Grande, Fedora; Conforti, Filomena; Abian, Olga CSIC ORCID; Velázquez-Campoy, Adriánartículo
openAccessTargeting intrinsically disordered.pdf.jpg30-Oct-2019Targeting intrinsically disordered proteins involved in cancerSantofimia-Castaño, P.; Rizzuti, Bruno; Xia, Y.; Abian, Olga CSIC ORCID; Peng, L.; Velázquez-Campoy, Adrián; Neira, José L. CSIC ORCID; Iovanna, Juan Lucioartículo