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openAccessA Phosphorylation-Induced.pdf.jpg11-Sep-2020A phosphorylation-induced switch in the nuclear localization sequence of the intrinsically disordered NUPR1 hampers binding to importinNeira, José L.; Rizzuti, Bruno; Jiménez-Alesanco, A.; Palomino-Schätzlein, Martina; Abian, Olga CSIC ORCID; Velázquez-Campoy, Adrián; Iovanna, Juan L.artículo
closedAccessaccesoRestringido.pdf.jpg2018Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1)Santofimia-Castaño, P.; Rizzuti, Bruno; Abian, Olga CSIC ORCID; Velázquez-Campoy, Adrián; Iovanna, Juan Lucio; Neira, J.L.artículo
openAccessCrowding Effects.pdf.jpg5-Jul-2021Crowding Effects on the Structure and Dynamics of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1Bonucci, Alessio; Palomino-Schätzlein, Martina; Malo de Molina, Paula; Arbe, Arantxa CSIC ORCID; Pierattelli, Roberta; Rizzuti, Bruno; Iovanna, Juan L.; Neira, José L.artículo
openAccess2020Dynamics of the intrinsically disordered inhibitor IF7 of glutamine synthetase in isolation and in complex with its partnerNeira, José L.; Ortore, M.G.; Florencio, Francisco J.; Muro-Pastor, M. Isabel CSIC ORCID; Rizzuti, Brunoartículo
closedAccessaccesoRestringido.pdf.jpg17-Jul-2019Dynamics of the intrinsically disordered protein NUPR1 in isolation and in its fuzzy complexes with DNA and prothymosin αNeira, José L.; Palomino-Schätzlein, M.; Ricci, C.; Ortore, M.G.; Rizzuti, Bruno; Iovanna, J.L.artículo
closedAccessaccesoRestringido.pdf.jpg2020Human importin α3 and its N-terminal truncated form, without the importin-β-binding domain, are oligomeric species with a low conformational stability in solutionDíaz-García, Clara; Hornos, Felipe; Giudici, A. Marcela; Cámara-Artigas, Ana; Luque-Ortega, Juan Román CSIC ORCID ; Arbe, Arantxa CSIC ORCID; Rizzuti, Bruno; Alfonso, Carlos CSIC ORCID ; Forwood, Jade K.; Iovanna, Juan L.; Gómez, Javier; Prieto, Manuel; Coutinho, Ana; Neira, José L.artículo
openAccesssrep39732.pdf.jpg2017Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic AdenocarcinomaNeira, J.L.; Bintz, J.; Arruebo, María; Rizzuti, Bruno; Bonacci, T.; Vega, Sonia; Lanas, A.; Velázquez-Campoy, Adrián; Iovanna, Juan Lucio; Abian, Olga CSIC ORCIDartículo
openAccessPNAS-2017-Santofimia-Castaño-E6332-41.pdf.jpg18-Jul-2017Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1BSantofimia-Castaño, Patricia; Rizzuti, Bruno; Pey, Ángel L.; Soubeyran, Philippe; Vidal, Miguel CSIC ORCID ; Urrutia, Raúl; Iovanna, Juan Lucio; Neira, José L.artículo
closedAccessaccesoRestringido.pdf.jpgJun-2017Intrinsically disordered inhibitor of glutamine synthetase is a functional protein with random-coil-like pKa valuesCozza, Concetta; Neira, José L.; Florencio, Francisco J.; Muro-Pastor, M. Isabel CSIC ORCID ; Rizzuti, Brunoartículo
openAccessPolyphenols from Citrus Tacle.pdf.jpg21-Sep-2021Polyphenols from citrus tacle® extract endowed with hmgcr inhibitory activity: An antihypercholesterolemia natural remedyGrande, Fedora; Occhiuzzi, María Antonietta; Perri, Maria Rosaria; Ioele, Giuseppina; Rizzuti, Bruno; Statti, Giancarlo; Garofalo, Antonioartículo
openAccessbiomedicines-09-00375.pdf.jpg2-Apr-2021Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin AnalogsRizzuti, Bruno; Grande, Fedora; Conforti, Filomena; Jiménez-Alesanco, A.; Ceballos-Laita, Laura CSIC ORCID; Ortega-Alarcon, David; Vega, Sonia; Reyburn, H. T. ; Abian, Olga CSIC ORCID; Velázquez-Campoy, Adriánartículo
openAccessijms-22-07048.pdf.jpg30-Jun-2021Seleno-Functionalization of Quercetin Improves the Non-Covalent Inhibition of Mpro and Its Antiviral Activity in Cells against SARS-CoV-2Mangiavacchi, Fancesca; Botwina, Pawel; Menichetti, Elena; Bagnoli, Luana; Rosati, Ornelo; Marini, Francesca; Fonseca, Sergio F.; Abenante, Laura; Alves, Diego; Dabrowska, Agnieszka; Kula-Pacurar, Anna; Ortega-Alarcon, David; Jiménez-Alesanco, A.; Ceballos-Laita, Laura CSIC ORCID; Vega, Sonia; Rizzuti, Bruno; Abian, Olga CSIC ORCID; Lenardão, Eder J.; Velázquez-Campoy, Adrián; Pyrc, Krzysztof; Sancineto, Luca; Santi, Claudioartículo
openAccessStructural stability_Abian.pdf.jpg1-Aug-2020Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screeningAbian, Olga CSIC ORCID; Ortega-Alarcon, David; Jiménez-Alesanco, A.; Ceballos-Laita, Laura CSIC ORCID; Vega, Sonia; Reyburn, H. T. ; Rizzuti, Bruno; Velázquez-Campoy, Adriánartículo
openAccesspharmaceuticals-14-00892.pdf.jpg1-Sep-2021Sub-Micromolar Inhibition of SARS-CoV-2 3CLpro by Natural CompoundsRizzuti, Bruno; Ceballos-Laita, Laura CSIC ORCID; Ortega-Alarcon, David; Jiménez-Alesanco, A.; Vega, Sonia; Grande, Fedora; Conforti, Filomena; Abian, Olga CSIC ORCID; Velázquez-Campoy, Adriánartículo
openAccessTargeting intrinsically disordered.pdf.jpg30-Oct-2019Targeting intrinsically disordered proteins involved in cancerSantofimia-Castaño, P.; Rizzuti, Bruno; Xia, Y.; Abian, Olga CSIC ORCID; Peng, L.; Velázquez-Campoy, Adrián; Neira, José L.; Iovanna, J.artículo
openAccessCterminuoligo.pdf.jpg2018The C terminus of the ribosomal-associated protein LrtA is an intrinsically disordered oligomerNeira, José L.; Giudici, A. Marcela; Hornos, Felipe; Arbe, Arantxa CSIC ORCID; Rizzuti, Brunoartículo
openAccessijms-19-01857.pdf.jpg24-Jun-2018The cyanobacterial ribosomal-associated protein LrtA from Synechocystis sp. PCC 6803 is an oligomeric protein in solution with chameleonic sequence propertiesContreras, Lellys M.; Sevilla, Paz CSIC ORCID; Cámara-Artigas, A.; Hernández-Cifre, José G.; Rizzuti, Bruno; Florencio, Francisco J.; Muro-Pastor, M. Isabel CSIC ORCID ; García de la Torre, José; Neira, José L.artículo
closedAccessaccesoRestringido.pdf.jpg30-Jan-2019The isolated C-terminal nuclear localization sequence of the breast cancer metastasis suppressor 1 is disorderedPantoja-Uceda, D.; Neira, José L.; Contreras, L.M.; Manton, C.A.; Welch, D.R.; Rizzuti, Brunoartículo
openAccessThe Paralogue of the Intrinsically.pdf.jpg8-Oct-2020The paralogue of the intrinsically disordered nuclear protein 1 has a nuclear localization sequence that binds to human importin α3Neira, José L.; Rizzuti, Bruno; Jiménez-Alesanco, A.; Abian, Olga CSIC ORCID; Velázquez-Campoy, Adrián; Iovanna, Juan L.artículo
openAccessThermal Liquid Biopsy.pdf.jpg13-Apr-2021Thermal Liquid Biopsy (TLB) of Blood Plasma as a Potential Tool to Help in the Early Diagnosis of Multiple SclerosisAnnesi, Ferdinanda; Hermoso-Durán, Sonia; Rizzuti, Bruno; Bruno, R.; Pirritano, Domenico; Petrone, Alfredo; Giudice, Francesco del; Ojeda, Jorge; Vega, Sonia; Sanchez-Gracia, O.; Velázquez-Campoy, Adrián; Abian, Olga CSIC ORCID; Guzzi, Ritaartículo