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Showing results 1 to 18 of 18
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openAccesstubulin_binding_Coderch.pdf.jpgMar-2013A structure-based design of new C2- and C13-substituted taxanes: Tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysisCoderch, Claire; Tang, Yong; Klett, Javier CSIC ORCID; Zhang, Shu-En; Ma, Yung-Tao; Shaorong, Wang; Matesanz, Ruth CSIC ; Pera, Benet CSIC; Canales, Ángeles CSIC ORCID; Jiménez-Barbero, Jesús CSIC ORCID; Morreale, Antonio; Díaz, José Fernando CSIC ORCID ; Fang, Wei-shuo S.; Gago, Federico CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg14-Jun-2011Corrigendum: Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and JTrigili, Chiara CSIC; Pera, Benet CSIC; Barbazanges, Marion; Cossy, Janine; Meyer, Christophe; Pineda, Oriol; Rodríguez-Escrich, Carles; Urpí, Félix; Vilarrasa, Jaume; Díaz, José Fernando CSIC ORCID ; Barasoain, Isabel CSIC corrigenda
openAccessJ. Biol. Chem.-2010-Bustamante-33184-96.pdf.jpg22-Oct-2010Cpl-7, a Lysozyme Encoded by a Pneumococcal Bacteriophage with a Novel Cell Wall-Binding MotifBustamante, Noemí CSIC; Campillo, Nuria E. CSIC ORCID ; García, Ernesto CSIC ORCID ; Gallego, Cristina; Pera, Benet CSIC; Diakun, Gregory P.; Saiz, José L.; García, Pedro CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Menéndez, Margarita CSIC ORCIDartículo
closedAccessrestringido.pdf.jpgJan-2012Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel SiteCalvo, Enrique; Barasoain, Isabel CSIC ; Matesanz, Ruth CSIC ; Pera, Benet CSIC; Camafeita, Emilio; Pineda, Oriol; Hamel, Ernest; Vanderwal, Christopher D.; Andreu, José Manuel CSIC ORCID ; López, Juan Antonio; Díaz, José Fernando CSIC ORCID artículo
openAccessPera et al 2015.pdf.jpg1-Nov-2015High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cellsPera, Benet CSIC; Calvo, María Nieves; Ambati, Srikanth; Jordi, Michel; Kahn, Alissa; Díaz, José Fernando CSIC ORCID ; Fang, Wei-shuo S.; Altmann, Karl-Heinz; Cerchietti, ,Leandro; Moore, Malcolm A. S.artículo
closedAccessaccesoRestringido.pdf.jpg1-Jun-2011Mecanismo de accion de los macrolidos citotoxicos amphinolidas X y JTrigili, Chiara CSIC; Pera, Benet CSIC; Barbazanges, Marion; Cossy, Janine; Meyer, Christophe; Pineda, Oriol; Rodríguez-Escrich, Carles; Urpí, Félix; Vilarrasa, Jaume; Díaz, José Fernando CSIC ORCID ; Barasoain, Isabel CSIC póster de congreso
closedAccess2-May-2011Mechanism of Action of Cytotoxic Macrolides Amphidinolide X and J.Trigili, Chiara CSIC; Pera, Benet CSIC; Barbazanges, Marion; Cossy, Janine; Meyer, Christophe; Pineda, Oriol; Rodríguez-Escrich, Carles; Urpí, Félix; Vilarrasa, Jaume; Díaz, José Fernando CSIC ORCID ; Barasoain, Isabel CSIC artículo
openAccessMatesanz_et_al_2011 Biophysical Journal.pdf.jpg21-Dec-2011Modulation of microtubule interprotofilament interactions by modified taxanesMatesanz, Ruth CSIC ; Rodríguez-Salarichs, Javier; Pera, Benet CSIC; Canales, Ángeles CSIC ORCID; Andreu, José Manuel CSIC ORCID ; Jiménez-Barbero, Jesús CSIC ORCID; Bras, Wim; Nogales, Aurora CSIC ORCID; Fang, Wei-shuo S.; Díaz, José Fernando CSIC ORCID artículo
closedAccess16-Aug-2010Molecular recognition of peloruside A by microtubules. The C24 primary alcohol is essential for biological activity.Pera, Benet CSIC; Razzak, Mina; Trigili, Chiara CSIC; Pineda, Oriol; Canales, Ángeles CSIC ORCID; Martínez Buey, Rubén CSIC ORCID CVN; Jiménez-Barbero, Jesús CSIC ORCID; Northcote, Peter; Paterson, Ian; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg16-Jul-2013New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanismPera, Benet CSIC; Barasoain, Isabel CSIC ; Pantazopoulou, Areti CSIC ORCID; Canales, Ángeles CSIC ORCID; Matesanz, Ruth CSIC ; Rodríguez-Salarichs, Javier; García-Fernández, Luis F.; Moneo, Victoria; Jiménez-Barbero, Jesús CSIC ORCID; Galmarini, Carlos M.; Cuevas, Carmen; Peñalva, Miguel Ángel CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Andreu, José Manuel CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg1-Apr-2014PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumorsMartínez-Díez, Marta; Guillén-Navarro, María José; Pera, Benet CSIC; Bouchet, Benjamin Pierre; Martínez-Leal, Juan Fernando; Barasoain, Isabel CSIC ; Cuevas, Carmen; Andreu, José Manuel CSIC ORCID ; García-Fernández, Luis F.; Díaz, José Fernando CSIC ORCID ; Avilés, Pablo; Galmarini, Carlos M.artículo
openAccesspro98.pdf.jpg2011Shotgun and targeted MS analyses pinpoint the zampanolide-tubulin interacting siteCalvo, Enrique; Field, Jessica J.; Pera, Benet CSIC; Zuwera, D.; López, Juan Antonio; Camafeita, Emilio; Barasoain, Isabel CSIC ; Altmann, Karl-Heinz; Díaz, José Fernando CSIC ORCID póster de congreso
closedAccessaccesoRestringido.pdf.jpgNov-2012Structure-activity relationships of novel substituted naphthalene diimides as anticancer agentsMilelli, Andrea; Tumiatti, Vicenzo; Micco, Marialuisa; Rosini, Michela; Zuccari, Guendalina; Raffaghello, Lizzia; Bianchi, Giovanna; Pistoia, Vito; Pistoia, Vito; Díaz, José Fernando CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Pera, Benet CSIC; Trigili, Chiara CSIC; Barasoain, Isabel CSIC ; Musetti, Caterina; Toniolo, Marianna; Sissi. Claudia; Alcaro, Stefano; Moraca, Federica; Zini, Maddalena; Stefanelli, Claudio; Minarini, Annaartículo
openAccessMatesanz et al_2014 _Bioorganic Medicinal Chemistry.pdf.jpg19-Jun-2014Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistancesMatesanz, Ruth CSIC ; Trigili, Chiara CSIC; Rodríguez-Salarichs, Javier; Pera, Benet CSIC; Jiménez-Barbero, Jesús CSIC ORCID; Canales, Ángeles CSIC ORCID; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID artículo
openAccessthermodynamics_Matesanz.pdf.jpgNov-2011Thermodynamics as a Tool for the Optimization of Drug Binding, Thermodynamics - Interaction Studies - Solids, Liquids and GasesMatesanz, Ruth CSIC ; Pera, Benet CSIC; Díaz, José Fernando CSIC ORCID capítulo de libro
closedAccessaccesoRestringido.pdf.jpg1-Jun-2011Zampanolida, un novedoso agente estabilizador de microtubulos quew se une covalentemente al sitio de paclitaxelField, Jessica J.; Pera, Benet CSIC; Canales, Ángeles CSIC ORCID; Zuwerra, D.; Trigili, Chiara CSIC; Kanakkanthara, Arun; Wakefield, St. John; Singh, A. Jonathan; Jiménez-Barbero, Jesús CSIC ORCID; Northcote, Peter; Miller, J.; López, Juan Antonio; Hamel, Ernest; Barasoain, Isabel CSIC ; Altmann, Karl-Heinz; Díaz, José Fernando CSIC ORCID póster de congreso
openAccessJNP_2017 Field et al.pdf.jpg12-Oct-2017Zampanolide binding to tubulin indicates crosstalk of taxane site with colchicine and nucleotide sitesField, Jessica J.; Pera, Benet CSIC; Estévez-Gallego, Juan CSIC ORCID ; Rodríguez-Salarichs, Javier; Sáez-Calvo, Gonzalo; Andreu, José Manuel CSIC ORCID ; Díaz, José Fernando CSIC ORCID artículo
openAccessField et al 2012_Chemistry and Biology.pdf.jpg22-Jun-2012Zampanolide, a potent new microtubule stabilizing agent, covalently reacts with the taxane luminal site in both tubulin alpha-beta-heterodimers and microtubulesField, Jessica J.; Pera, Benet CSIC; Calvo, Enrique; Canales, Ángeles CSIC ORCID; Zurwerra, Didier; Trigili, Chiara CSIC; Rodríguez-Salarichs, Javier; Matesanz, Ruth CSIC ; Kanakkanthara, Arun; Wakefield, St. John; Singh, A. Jonathan; Jiménez-Barbero, Jesús CSIC ORCID; Northcote, Peter; Miller, John H.; López, Juan Antonio; Hamel, Ernest; Barasoain, Isabel CSIC ; Altmann, Karl-Heinz; Díaz, José Fernando CSIC ORCID artículo