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DerechosPreviewFecha Public.TítuloAutor(es)Tipo
openAccesstubulin_binding_Coderch.pdf.jpgmar-2013A structure-based design of new C2- and C13-substituted taxanes: Tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysisCoderch, Claire; Tang, Yong; Klett, Javier ; Zhang, Shu-En; Ma, Yung-Tao; Shaorong, Wang; Matesanz, Ruth ; Pera, Benet ; Canales, Ángeles ; Jiménez-Barbero, Jesús ; Morreale, Antonio ; Díaz, José Fernando ; Fang, Wei-shuo S.; Gago, Federico Artículo
closedAccess2007Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studiesLa Regina, Giuseppe; Edler, Michael C.; Brancale, Andrea; Kandil, Sahar; Coluccia, Antonio; Piscitelli, Francesco; Hamel, Ernest; De Martino, Gabriella; Matesanz, Ruth ; Díaz, José Fernando ; Scovassi, Anna Ivana; Prosperi, Ennio; Lavecchia, Antonio; Novellino, Ettore; Artico, Marino; Silvestri, RomanoArtículo
openAccesscyclostreptin_Buey.pdf.jpgene-2007Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sitesBuey, Ruben M.; Calvo, Enrique; Barasoain, Isabel ; Pineda, Oriol; Edler, Michael C.; Matesanz, Ruth ; Cerezo, Gemma; Vanderwal, Christopher D.; Day, Billy W.; Sorensen, Erik J.; López, Juan Antonio; Andreu, José Manuel ; Hamel, Ernest; Díaz, José Fernando Artículo
closedAccessrestringido.pdf.jpgene-2012Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel SiteCalvo, Enrique; Barasoain, Isabel ; Matesanz, Ruth ; Pera, Benet ; Camafeita, Emilio; Pineda, Oriol; Hamel, Ernest; Vanderwal, Christopher D.; Andreu, José Manuel ; López, Juan Antonio; Díaz, José Fernando Artículo
closedAccessrestringido.pdf.jpg5-oct-2009Epothilone Analogs with Benzimidazole and Quinoline Side Chains: Chemical Synthesis, Antiproliferative Activity, and Interactions with TubulinDietrich, Silvia Anthoine; Lindauer, Renate; Stierling, Claire; Gertsch, Jürg; Matesanz, Ruth ; Notararigo, Sara ; Díaz, José Fernando ; Altmann, Karl-HeinzArtículo
openAccessMatesanz_et_al_2011 Biophysical Journal.pdf.jpg21-dic-2011Modulation of microtubule interprotofilament interactions by modified taxanesMatesanz, Ruth ; Rodríguez-Salarichs, Javier; Pera, Benet ; Canales, Ángeles ; Andreu, José Manuel ; Jiménez-Barbero, Jesús ; Bras, Wim; Nogales, Aurora ; Fang, Wei-shuo S.; Díaz, José Fernando Artículo
openAccessMicrob. Cell Fact. _Matesanz_2015.pdf.jpg9-oct-2015Molecular adaptation of Lactobacillus plantarum WCFS1 to gallic acid revealed by genome‑scale transcriptomic signature and physiological analysisReverón, Inés ; Rivas, Blanca de las ; Matesanz, Ruth ; Muñoz, Rosario ; López de Felipe, Félix Artículo
closedAccessrestringido.pdf.jpg5-mar-2012Multiple keys for a single lock: the unusual structural plasticity of the Nucleotidyltransferase (4’)/kanamycin complex ChemistryMatesanz, Ruth ; Díaz, José Fernando ; Corzana, Francisco; Santana, Andrés G. ; Bastida, Agatha; Asensio, Juan Luis Artículo
openAccessMatesanz-Ruth.pdf.jpg2009Optimización de la interacción microtúbulo-taxol: Diseño de taxanos de alta afinidadMatesanz, Ruth Tesis
closedAccessMatesanz et al-2008_Chemistry and Biology.pdf.jpg23-jun-2008Optimization of Taxane Binding to Microtubules: Binding Affinity Dissection and Incremental Construction of a High-Affinity Analog of PaclitaxelMatesanz, Ruth ; Barasoain, Isabel ; Yang, C.G.; Wan, L.; Li, X.; Inés, C. de; Coderch, Claire; Gago, Federico ; Jiménez-Barbero, Jesús ; Andreu, José Manuel ; Fang, Wei-shuo S.; Díaz, José Fernando Artículo
openAccessmolecules-2016.pdf.jpg3-ago-2016Synthesis, biological profiling and determination of the tubulin-bound conformation of 12-Aza-epothilones (azathilones)Jantsch, Andrea; Nieto, Lidia ; Gertsch, Jürg; Rodríguez-Salarichs, Javier; Matesanz, Ruth ; Jiménez-Barbero, Jesús ; Díaz, José Fernando ; Canales, Ángeles ; Altmann, Karl-HeinzArtículo
openAccessmolecules-21-01010.pdf.jpg3-ago-2016Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones)Jantsch, Andrea; Nieto, Lidia ; Gertsch, Jürg; Rodríguez-Salarichs, Javier; Matesanz, Ruth ; Jiménez-Barbero, Jesús ; Díaz, José Fernando ; Canales, Ángeles ; Altmann, Karl-HeinzArtículo
openAccessMatesanz et al_2014 _Bioorganic Medicinal Chemistry.pdf.jpg19-jun-2014Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistancesMatesanz, Ruth ; Trigili, Chiara ; Rodríguez-Salarichs, Javier; Pera, Benet ; Jiménez-Barbero, Jesús ; Canales, Ángeles ; Barasoain, Isabel ; Díaz, José Fernando Artículo
closedAccessrestringido.pdf.jpgago-2008The bound conformation of microtubule-stabilizing agents: NMR insights into the bioactive 3D structure of discodermolide and dictyostatinCanales, Ángeles ; Matesanz, Ruth ; Gardner, Nicola M.; Andreu, José Manuel ; Paterson, Ian; Díaz, José Fernando ; Jiménez-Barbero, Jesús Artículo
closedAccessrestringido.pdf.jpg15-jun-2007The Total Synthesis and Biological Properties of the Cytotoxic Macrolide FD-891 and Its Non-Natural (Z)-C12 IsomerGarcía-Fortanet, Jorge Isabel Barasoain; Murga, Juan; Carda, Miguel; Marco, J. Alberto; Matesanz, Ruth ; Díaz, José Fernando ; Barasoain, Isabel Artículo
openAccessthermodynamics_Matesanz.pdf.jpgnov-2011Thermodynamics as a Tool for the Optimization of Drug Binding, Thermodynamics - Interaction Studies - Solids, Liquids and GasesMatesanz, Ruth ; Pera, Benet ; Díaz, José Fernando Capítulo de libro
openAccessSaez-Calvo-et-al.2017.pdf.jpg22-jun-2017Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of TubulinSáez-Calvo, Gonzalo; Balaguer, Francisco de Asís; Barasoain, Isabel ; Rodríguez-Salarichs, Javier; Muñoz-Hernández, Hugo; Berbís, Manuel Álvaro ; Peñalva, Miguel Ángel ; Matesanz, Ruth ; Canales, Ángeles ; Jiménez-Barbero, Jesús ; Andreu, José Manuel ; Díaz, José Fernando Artículo
openAccessField et al 2012_Chemistry and Biology.pdf.jpg22-jun-2012Zampanolide, a potent new microtubule stabilizing agent, covalently reacts with the taxane luminal site in both tubulin alpha-beta-heterodimers and microtubulesField, Jessica J.; Pera, Benet ; Calvo, Enrique; Canales, Ángeles ; Zurwerra, Didier; Trigili, Chiara ; Rodríguez-Salarichs, Javier; Matesanz, Ruth ; Kanakkanthara, Arun; Wakefield, St. John; Singh, A. Jonathan; Jiménez-Barbero, Jesús ; Northcote, Peter; Miller, John H.; López, Juan Antonio; Hamel, Ernest; Barasoain, Isabel ; Altmann, Karl-Heinz; Díaz, José Fernando Artículo