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openAccesspharmaceuticals-14-01323-v3.pdf.jpg17-Dec-20212-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory ActivityMartín-López, Juan; Codony, Sandra; Bartra Cabré, Clara CSIC ORCID; Morisseau, Christophe; Loza, María Isabel; Sanfeliu, Coral CSIC ORCID; Hammock, Bruce D.; Brea, José Manuel; Vázquez, Santiagoartículo
openAccess20 JMC 9237  (2-Oxaadamant-1-yl ureas).pdf.jpg20202-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute PancreatitisCodony, Sandra; Pujol, Eugènia; Pizarro, J.; Feixas, Ferran; Valverde,E.; Loza, María Isabel; Brea, José Manuel; Saez, Elena; Oyarzabal, Julen; Pineda-Lucena, Antonio CSIC ORCID; Pérez, Belén CSIC ORCID; Pérez, Concepción CSIC ORCID; Rodríguez-Franco, María Isabel CSIC ORCID ; Leiva, Rosana; Osuna, Sílvia; Morissea, Christophe; Hammock, Bruce D.; Vázquez-Carrera, Manuel; Vázquez, Santiagoartículo
openAccess1-s2.0-S0223523423000065-main.pdf.jpg20238-Amide and 8-carbamate substitution patterns as modulators of 7-hydroxy-4-methylcoumarin's antidepressant profile: Synthesis, biological evaluation and docking studiesMatos, María de Jesús; Novo, Paula; Mayán, Lucía; Torres, I.; Uriarte, Eugenio; Yáñez, Matilde; Fontenla, José Ángel; Ortuso, F.; Alcaro, Stefano; Procopio, Francesca; Rodríguez-Franco, María Isabel CSIC ORCID ; Val, Cristina; Loza, María Isabel; Brea, José Manuel; Borges, Fernanda; Viña, Doloresartículo
openAccessIzquierdo I. A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals ....pdf.jpgFeb-2020A comprehensive tyrosine phosphoproteomic analysis reveals novel components of the platelet CLEC-2 signaling cascadeIzquierdo, Irene; Barrachina, Maria N.; Hermida-Nogueira, Lidia; Casas, Vanessa CSIC; Morán, Luis A.; Lacerenza, Serena; Pinto Llorente, Roberto CSIC; Eble, Johannes A.; Ríos, Vivian de los CSIC ORCID ; Domínguez, Eduardo; Loza, María Isabel; Casal, J. Ignacio CSIC ORCID ; Carrascal, Montserrat CSIC ORCID; Abián, Joaquín CSIC ORCID; García, Ángelartículo
closedAccessaccesoRestringido.pdf.jpg18-Jul-2023A new family of soluble epoxide hydrolase inhibitors: in vivo evaluation in a murine model of chemotherapy-induced neuropathic painVázquez, Santiago; Codony, Sandra; Jora, Beatrice; Turcu, Andreea L.; Calvó-Tusell, Carla; Morisseau, Christophe; Loza, María Isabel; Brea, José Manuel; Bartra Cabré, Clara CSIC ORCID; Sanfeliu, Coral CSIC ORCID; Pérez, Belén CSIC ORCID; Griñán-Ferré, Christian; Pallàs, Mercè; Hammock, Bruce D.; Osuna, Sílvia; Feixas, Ferran; Cobos, Enrique J.póster de congreso
openAccessA new family of subnanomolar inhibitors of soluble epoxide hydrolase.pdf.jpg3-Apr-2022A new family of subnanomolar inhibitors of soluble epoxide hydrolaseEscolano, Carmen; Bagán, Andrea; Turcu, Andreea L.; Morisseau, Christophe; Loza, María Isabel; Brea, José Manuel; Bartra Cabré, Clara CSIC ORCID; Sanfeliu, Coral CSIC ORCID; Hammock, Bruce D.; Vázquez, Santiagopóster de congreso
openAccessAbas_JMedChem_2020_postprint.pdf.jpg9-Apr-2020Bicyclic alfa-iminophosphonates as highly affinity imidazoline I2 receptor ligands for Alzheimer’s DiseaseAbás, Sònia; Rodríguez Arévalo, Sergio; Bagán, Andrea; Griñán-Ferré, Christian; Vasilopoulou, Foteini; Brocos Mosquera, Iria; Muguruza, Carolina; Pérez, Belén CSIC ORCID; Molins, Elies CSIC ORCID ; Luque, F. Javier; Pérez Lozano, Pilar; Jonghe, Steven de; Daelemans, Dirk; Naesens, Lieve; Brea, José Manuel; Loza, María Isabel; Hernández Hernández, Elena; García-Sevilla, Jesús Andrés CSIC; García Fuster, M. Julia; Radan, Milica; Djikic, Teodora; Nikolic, Katarina; Pallàs, Mercè; Callado, Luis F.; Escolano, Carmenartículo
openAccessJMC2020.pdf.jpg24-Jul-2020Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6Pérez-Areales, F. Javier; Garrido, María CSIC; Aso, Ester; Bartolini, Manuela; De Simone, Angela; Espargaró, Alba; Ginex, Tiziana CSIC ORCID ; Sabate, Raimon; Pérez, Belén CSIC ORCID; Andrisano, Vincenza; Puigoriol-Illamola, Dolors; Pallàs, Mercè; Luque, F. Javier; Loza, María Isabel; Brea, José Manuel; Ferrer, Isidro; Ciruela, Francisco; Messeguer Peypoch, Ángel CSIC ORCID; Muñoz-Torrero, Diegoartículo
openAccessES2391732A1.pdf.jpg29-Nov-2012Derivados heterocíclicos inhibidores de fosfodiesterasa 7Gil, Carmen CSIC ORCID ; Martínez Gil, Ana CSIC ORCID ; Redondo, Miriam CSIC; Campillo, Nuria E. CSIC ORCID ; Pérez, Daniel I. CSIC ORCID; Loza, María Isabel; Cadavid, María Isabel; Brea, José Manuel; Pérez Castillo, Ana CSIC ORCIDsolicitud de patente
openAccessacs.jmedchem.1c02150.pdf.jpg24-Mar-2022Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's DiseaseCodony, Sandra; Pont, Caterina; Griñán-Ferré, Christian; Di Pede-Mattatelli, Ania CSIC ORCID; Calvó-Tusell, Carla; Feixas, Ferran; Osuna, Sílvia; Jarné-Ferrer, Júlia; Naldi, Marina; Bartolini, Manuela; Loza, María Isabel; Brea, José Manuel; Pérez, Belén CSIC ORCID; Bartra Cabré, Clara CSIC ORCID; Sanfeliu, Coral CSIC ORCID; Juárez-Jiménez, Jordi; Morisseau, Christophe; Hammock, Bruce D.; Pallàs, Mercè; Vázquez, Santiago; Muñoz-Torrero, Diegoartículo
openAccessEffect of phosphodiesterase.pdf.jpg2012Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compoundsRedondo, Miriam CSIC; Brea, José Manuel; Pérez, Daniel I. CSIC ORCID; Soteras, Ignacio CSIC ORCID; Val, Cristina; Pérez, Concepción CSIC ORCID; Morales-García, José A. CSIC ORCID; Alonso-Gil, Sandra CSIC; Paul-Fernández, Nuria CSIC; Martín-Álvarez, Rocío CSIC; Cadavid, María Isabel; Loza, María Isabel; Pérez Castillo, Ana CSIC ORCID; Mengod Los Arcos, Guadalupe CSIC ORCID; Campillo, Nuria E. CSIC ORCID ; Martínez Gil, Ana CSIC ORCID ; Gil, Carmen CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg2020Essential role of the C148–C227 disulphide bridge in the human 5-HT2A homodimeric receptorCimadevila, M.; Gómez-García, L.; Martínez, A.L.; Iglesias, A.; López-Giménez, Juan F. CSIC ORCID; Castro, M.; Cadavid, María Isabel; Loza, María Isabel; Brea, J.artículo
closedAccessaccesoRestringido.pdf.jpg11-Mar-2009Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine(2A) receptor homodimersVilaró, Maria Teresa CSIC ORCID; Mengod Los Arcos, Guadalupe CSIC ORCID; Loza, María Isabelartículo
closedAccessaccesoRestringido.pdf.jpg2021His452Tyr polymorphism in the human 5-HT2A receptor affects clozapine-induced signaling networks revealed by quantitative phosphoproteomicsMartín-Guerrero, S.M.; Alonso, P.; Iglesias, A.; Cimadevila, M.; Brea, J.; Loza, María Isabel; Casado, Pedro; Martín-Oliva, David; Cutillas, Pedro; González-Maeso, Javier; López-Giménez, Juan F. CSIC ORCIDartículo
openAccess7-Sep-2023Hitting a new combination of biological targets to cope with Alzheimer's diseaseMartínez-Conde, Noemí; Granje, Marc; Digito, Francesca; Mullins, Joseph J.; Griñán-Ferré, Christian; Jarne-Ferrer, Júlia; Naldi, Marina; Bartolini, Manuela; Loza, María Isabel; Brea, José Manuel; Pérez, Belén CSIC ORCID; Bartra Cabré, Clara CSIC ORCID; Sanfeliu, Coral CSIC ORCID; Morisseau, Christophe; Hammock, Bruce D.; Pallàs, Mercè; Vázquez, Santiago; Muñoz-Torrero, Diegocomunicación de congreso
closedAccessaccesoRestringido.pdf.jpg7-Mar-2023In vivo evaluation of soluble epoxide hydrolase inhibitors in murine models of allodynia, chemotherapy-induced neuropathic pain and visceral painVázquez, Santiago; Codony, Sandra; Jora, Beatrice; Entrena, José M.; Santos-Caballero, M.; Turcu, Andreea L.; Calvó-Tusell, Carla; González-Cano, Rafael; Morisseau, Christophe; Martínez, Antón L.; Bartra Cabré, Clara CSIC ORCID; Corpas, Rubén CSIC ORCID; Sanfeliu, Coral CSIC ORCID; Pérez, Belén CSIC ORCID; Hammock, Bruce D.; Pérez, Concepción CSIC ORCID; Rodríguez-Franco, María Isabel CSIC ORCID; Griñán-Ferré, Christian; Pallàs, Mercè; Osuna, Sílvia; Feixas, Ferran; Loza, María Isabel; Brea, José Manuel; Cobos, Enrique J.póster de congreso
closedAccessaccesoRestringido.pdf.jpg2014Modulation of cAMP-specific PDE without emetogenic activity: New sulfide-like PDE7 inhibitorsGarcía, Ana M. CSIC ORCID; Brea, José Manuel; Morales-García, José A. CSIC ORCID; Pérez, Daniel I. CSIC ORCID; González, Alejandro CSIC ORCID; Alonso-Gil, Sandra CSIC; Conde, Santiago CSIC; Cadavid, María Isabel; Loza, María Isabel; Pérez Castillo, Ana CSIC ORCID; Martínez Gil, Ana CSIC ORCID ; Gil, Carmen CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg2001Multiple conformations of native and recombinant human 5-hydroxytryptamine2A receptors are labeled by agonists and discriminated by antagonistsLópez-Giménez, Juan F. CSIC ORCID; Villazón, María; Brea, José Manuel; Loza, María Isabel; Palacios, José M.; Mengod Los Arcos, Guadalupe CSIC ORCID; Vilaró, Maria Teresa CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg2012Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke modelRedondo, Miriam CSIC; Zarruk, Juan G.; Ceballos, Placido CSIC; Pérez, Daniel I. CSIC ORCID; Pérez, Concepción CSIC ORCID; Pérez Castillo, Ana CSIC ORCID; Moro, María A.; Brea, José Manuel; Val, Cristina; Cadavid, María Isabel; Loza, María Isabel; Campillo, Nuria E. CSIC ORCID ; Martínez Gil, Ana CSIC ORCID ; Gil, Carmen CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg8-Dec-2001New serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor antagonists: Synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanonesBrea, José Manuel; Mengod Los Arcos, Guadalupe CSIC ORCID; Loza, María Isabelartículo