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openAccessPREPRINTCrystal_structures_of_taxane-tubulin_complexes_Imp.pdf.jpg2021Crystal structures of taxane-tubulin complexes: Implications for the mechanism of microtubule stabilization by TaxolProta, Andrea E.; Lucena-Agell, Daniel CSIC ORCID ; Ma, Yuntao; Estévez-Gallego, Juan CSIC ORCID ; Roca, Carlos CSIC ORCID; Josa-Prado, Fernando CSIC ORCID; Goossens, Kenneth; Giménez-Abián, Juan F. CSIC ; Li, Shuo; Canales, Ángeles CSIC ORCID; Bargsten, Katja; Andreu, José Manuel CSIC ORCID ; Altmann, Karl-Heinz; Olieric, Natacha; Kamimura, Shinji; Mühlethaler, Tobias; Oliva, María A. CSIC ORCID ; Steinmetz, Michel O.; Fang, Wei-Shuo; Díaz, José Fernando CSIC ORCID preprint
openAccessjcm-09-01681.pdf.jpg2-jun-2020Functional heterogeneity of mouse and human brain OPCs: Relevance for preclinical studies in multiple sclerosisBribián, Ana CSIC; Medina-Rodríguez, Eva M.; Josa-Prado, Fernando CSIC ORCID; García-Álvarez, Isabel; Machín-Díaz, Isabel; Esteban, Pedro F.; Murcia-Belmonte, Verónica CSIC ORCID; Vega-Zelaya, Lorena; Pastor, Jesús; Garrido, Leoncio CSIC ORCID; Castro Soubriet, Fernando de CSIC ORCIDartículo
openAccessScientific Reports 2017.pdf.jpg31-ago-2017Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer propertiesGilson, Pauline; Josa-Prado, Fernando CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Busser, Benoitartículo
openAccessPNAS_.Unterhauser_2019.pdf.jpg26-feb-2019Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubulestabilizing activitiesUnterhauser, Katrin; Poltl, Lisa; Schneditz, Georg; Kienesberger, Sabine; Glabonjat, Ronald A.; Kitsera, Maksym; Pletz, Jakob; Josa-Prado, Fernando CSIC ORCID; Dornisch, Elisabeth; Lembacher-Fadum, Christian; Roier, Sandro; Gorkiewicz, Gregor; Lucena-Agell, Daniel CSIC ORCID ; Barasoain, Isabel CSIC ; Kroutil, Wolfgang; Wiedner, Marc; Loizou, Joanna I.; Breinbauer, Rolf; Díaz, José Fernando CSIC ORCID ; Schild, Stefan; Hog̈enauer, Christoph; Zechner, Ellen L.artículo
embargoedAccessEuropean Journal of Medicinal Chemistry_Ma et al._2023.pdf.jpg5-nov-2023Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potencyMa, Yuntao; Josa-Prado, Fernando CSIC ORCID; Essif, Jacob Nathaniel; Liu, Shuqi; Li, Shuo; Lucena-Agell, Daniel CSIC ORCID ; Chan, Peter; Goossens, Kenneth; Hortigüela, Rafael CSIC ORCID; Matesanz, Ruth CSIC ; Wang, Yingjie; Gago, Federico CSIC ORCID; Wang, Hongbo; Risinger, April L.; Díaz, José Fernando CSIC ORCID ; Fang, Wei-Shuoartículo
openAccesselife_prota_2023.pdf.jpg6-mar-2023Structural insight into the stabilization of microtubules by taxanesProta, Andrea E.; Lucena-Agell, Daniel CSIC ORCID ; Ma, Yuntao; Estévez-Gallego, Juan CSIC ORCID ; Li, Shuo; Bargsten, Katja; Josa-Prado, Fernando CSIC ORCID; Altmann, Karl-Heinz; Gaillard, Natacha; Kamimura, Shinji; Mühlethaler, Tobias; Gago, Federico CSIC ORCID; Oliva, María A. CSIC ORCID ; Steinmetz, Michel O.; Fang, Wei-Shuo; Díaz, José Fernando CSIC ORCID artículo
openAccesselife-Estévez-Gallego-2020.pdf.jpg10-mar-2020Structural model for differential cap maturation at growing microtubule endsEstévez-Gallego, Juan CSIC ORCID ; Josa-Prado, Fernando CSIC ORCID; Ku, Siou; Martínez Buey, Rubén CSIC ORCID; Balaguer, Francisco de Asís CSIC ORCID; Prota, Andrea E.; Lucena-Agell, Daniel CSIC ORCID ; Kamma-Lorger, C.S.; Yagi, Toshiki; Iwamoto, Hiroyuki; Duchesne, Laurence; Barasoain, Isabel CSIC ; Steinmetz, Michel O.; Chrétien, Denis; Kamimura, Shinji; Díaz, José Fernando CSIC ORCID ; Oliva, María A. CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg2021Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and downregulation of c-MycAgut, Raül; Falomir, Eva; Murga, Juan; Martín-Beltrán, Celia; Gil-Edo, Raquel; Pla, Alberto; Carda, Miguel; Díaz, José Fernando CSIC ORCID ; Josa-Prado, Fernando CSIC ORCID; Marco, J. Albertoartículo