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openAccessA Phosphorylation-Induced.pdf.jpg11-Sep-2020A phosphorylation-induced switch in the nuclear localization sequence of the intrinsically disordered NUPR1 hampers binding to importinNeira, José L. CSIC ORCID; Rizzuti, Bruno; Jiménez-Alesanco, Ana CSIC; Palomino-Schätzlein, Martina; Abian, Olga CSIC ORCID; Velázquez-Campoy, Adrián; Iovanna, Juan Lucioartículo
closedAccessaccesoRestringido.pdf.jpg2018Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1)Santofimia-Castaño, P.; Rizzuti, Bruno; Abian, Olga CSIC ORCID; Velázquez-Campoy, Adrián; Iovanna, Juan Lucio; Neira, J.L.artículo
closedAccessaccesoRestringido.pdf.jpg3-May-2005Anti-inflammatory effects of pancreatitis associated protein in inflammatory bowel diseaseGironella, Meritxell; Iovanna, Juan Lucio; Sans, Miquel; Gil, Félix; Peñalva, Mireia; Closa, Daniel CSIC ORCID; Miquel, Rosa; Piqué, Josep Maria; Panés, Juliánartículo
openAccessJCI37948.v1.pdf.jpg1-Apr-2009Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cellsSalazar, María CSIC; Carracedo, Arkaitz; Salanueva, Íñigo J.; Hernández-Tiedra, Sonia; Lorente, Mar; Egia, Ainara; Vázquez Pérez, Patricia CSIC ORCID; Blázquez, Cristina; Torres, Sofía CSIC ORCID; García, Stéphane; Nowak, Jonathan; Fimia, Gian María; Piacentini, Mauro; Cecconi, Francesco; Pandolfi, Pier Paolo; González-Feria, Luis; Iovanna, Juan Lucio; Guzmán, Manuel; Boya, Patricia CSIC ORCID ; Velasco, Guillermoartículo
openAccessCrowding Effects.pdf.jpg5-Jul-2021Crowding Effects on the Structure and Dynamics of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1Bonucci, Alessio; Palomino-Schätzlein, Martina; Malo de Molina, Paula CSIC ORCID; Arbe, Arantxa CSIC ORCID; Pierattelli, Roberta; Rizzuti, Bruno; Iovanna, Juan Lucio; Neira, José L. CSIC ORCIDartículo
openAccessjournal.pone.0078101.pdf.jpg2013Deciphering the Binding between Nupr1 and MSL1 and Their DNA-Repairing Activity.Aguado-Llera, David; Hamidi, T.; Domènech, Rosa; Pantoja-Uceda, D.; Gironella, Meritxell; Santoro, Jorge CSIC; Velázquez-Campoy, Adrián; Neira, J.L.; Iovanna, Juan Lucioartículo
openAccessintrinsically_disordered_proteins.pdf.jpg3-Oct-2021Design of inhibitors of the intrinsically disordered protein NUPR1: balance between drug affinity and target functionRizzuti, Bruno; Lan, Wenjun; Santofimia-Castaño, Patricia; Zhou, Zhengwei; Velázquez-Campoy, Adrián; Abián, Olga; Peng, Ling; Neira, José L. CSIC ORCID; Xia, Yi; Iovanna, Juan Lucioartículo
openAccessintrinsically_disordered_proteins.pdf.jpg16-May-2019Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigmSantofimia-Castaño, Patricia; Rizzuti, Bruno; Xia, Yi; Abian, Olga CSIC ORCID; Peng, Ling; Velázquez-Campoy, Adrián; Iovanna, Juan Lucio; Neira, José L. CSIC ORCIDartículo
openAccessDNA_Methylation_o_ PI3K_AKT_Pathway-Related Genes_Faleiro_PV_Art2021.pdf.jpg2021Dna methylation of pi3k/akt pathway-related genes predicts outcome in patients with pancreatic cancer: A comprehensive bioinformatics-based studyFaleiro, Inês; Palma Roberto, Vânia; Demirkol Canli, Secil; Fraunhoffer, Nicolas A.; Iovanna, Juan Lucio; Osmay Gure, Ali; Link, Wolfgang CSIC ORCID; Castelo-Branco, Pedroartículo
closedAccessaccesoRestringido.pdf.jpg17-Jul-2019Dynamics of the intrinsically disordered protein NUPR1 in isolation and in its fuzzy complexes with DNA and prothymosin αNeira, José L. CSIC ORCID; Palomino-Schätzlein, M.; Ricci, C.; Ortore, M.G.; Rizzuti, Bruno; Iovanna, Juan Lucioartículo
closedAccessaccesoRestringido.pdf.jpg2007Experimental acute pancreatitis in PAP/HIP knock-out miceGironella, Meritxell; Folch-Puy, Emma CSIC ORCID ; Closa, Daniel CSIC ORCID; Iovanna, Juan Lucioartículo
closedAccessaccesoRestringido.pdf.jpg2020Human importin α3 and its N-terminal truncated form, without the importin-β-binding domain, are oligomeric species with a low conformational stability in solutionDíaz-García, Clara; Hornos, Felipe; Giudici, A. Marcela; Cámara-Artigas, Ana; Luque-Ortega, Juan Román CSIC ORCID ; Arbe, Arantxa CSIC ORCID; Rizzuti, Bruno; Alfonso, Carlos CSIC ORCID ; Forwood, Jade K.; Iovanna, Juan Lucio; Gómez, Javier; Prieto, Manuel; Coutinho, Ana; Neira, José L. CSIC ORCIDartículo
openAccesssrep39732.pdf.jpg2017Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic AdenocarcinomaNeira, J.L.; Bintz, J.; Arruebo, María; Rizzuti, Bruno; Bonacci, T.; Vega, Sonia CSIC ORCID; Lanas, A.; Velázquez-Campoy, Adrián; Iovanna, Juan Lucio; Abian, Olga CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg15-Nov-2015IL17 functions through the novel REG3β-JAK2-STAT3 inflammatory pathway to promote the transition from chronic pancreatitis to pancreatic cancerLoncle, Céline; Bonjoch, Laia CSIC ORCID; Folch-Puy, Emma CSIC ORCID ; Closa, Daniel CSIC ORCID; Iovanna, Juan Lucioartículo
openAccessInduction of Apoptosis_Gajate_PV_Art2021.pdf.jpg2021Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy InhibitionGajate, Consuelo CSIC ORCID ; Gayet, Odile; Fraunhoffer, Nicolas A.; Iovanna, Juan Lucio; Dusetti, Nelson; Mollinedo, Faustino CSIC ORCID artículo
openAccessPNAS-2017-Santofimia-Castaño-E6332-41.pdf.jpg18-Jul-2017Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1BSantofimia-Castaño, Patricia; Rizzuti, Bruno; Pey, Ángel L.; Soubeyran, Philippe; Vidal, Miguel CSIC ORCID ; Urrutia, Raúl; Iovanna, Juan Lucio; Neira, José L. CSIC ORCIDartículo
openAccessNUPR1.pdf.jpg28-Mar-2019Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosisSantofimia-Castaño, Patricia; Xia, Yi; Lan, Wenjun; Zhou, Zhengwei; Huang, Can; Peng, Ling; Soubeyran, Philippe; Velázquez-Campoy, Adrián; Abián, Olga; Rizzuti, Bruno; Neira, José L. CSIC ORCID; Iovanna, Juan Lucioartículo
openAccessMice with targeted disruption.pdf.jpg8-Sep-2003Mice with targeted disruption of p8 gene show increased sensitivity to lipopolysaccharide and DNA microarray analysis of livers reveals an aberrant gene expression responseVasseur, Sophie; Hoffmeister, Albrecht; García-Montero, Andrés CSIC ORCID; Barthet, Marc; Saint-Michel, Laure; Berthézène, Patrice; Fiedler, Fritz; Closa, Daniel CSIC ORCID; Dagom, Jean-Charles; Iovanna, Juan Lucioartículo
closedAccessaccesoRestringido.pdf.jpg20-Feb-2004p8 Improves Pancreatic Response to Acute Pancreatitis by Enhancing the Expression of the Anti-inflammatory Protein Pancreatitis-associated Protein IVasseur, Sophie; Folch-Puy, Emma CSIC ORCID ; Hlouschek, Verena; García, Stéphane; Fiedler, Fritz; Lerch, Markus M.; Dagorn, Jean Charles; Closa, Daniel CSIC ORCID; Iovanna, Juan Lucioartículo
closedAccessaccesoRestringido.pdf.jpg15-Mar-2006Pancreatitis-associated protein I Suppresses NF-κB activation through a JAK/STAT-mediated mechanism in epithelial cellsFolch-Puy, Emma CSIC ORCID ; Granell, Susana; Dagorn, Jean Charles; Iovanna, Juan Lucio; Closa, Daniel CSIC ORCIDartículo