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Browsing by Author Díaz, José Fernando

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openAccessNature Communications_Menchon_2018.pdf.jpg29-May-2018A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulinMenchon, Grégory; Lucena-Agell, Daniel; Díaz, José Fernando ; Steinmetz, Michel O.Artículo
openAccesstubulin_binding_Coderch.pdf.jpgMar-2013A structure-based design of new C2- and C13-substituted taxanes: Tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysisCoderch, Claire; Tang, Yong; Klett, Javier ; Zhang, Shu-En; Ma, Yung-Tao; Shaorong, Wang; Matesanz, Ruth ; Pera, Benet ; Canales, Ángeles ; Jiménez-Barbero, Jesús ; Morreale, Antonio ; Díaz, José Fernando ; Fang, Wei-shuo S.; Gago, Federico Artículo
openAccessJ. Biol. Chem.-2001-D__az-17307-15.pdf.jpg18-May-2001Activation of cell division protein FtsZ. Control of switch loop T3 conformation by the nucleotide gamma-phosphateDíaz, José Fernando ; Kralicek, Andrew; Mingorance, Jesús; Palacios, Juan Manuel; Vicente, Miguel; Andreu, José Manuel Artículo
openAccessOncotarget.pdf.jpg20-May-2016Antivascular and antitumor properties of the tubulin-binding chalcone TUB091Canela, María-Dolores ; Noppen, Sam; Bueno, Oskía; Prota, Andrea E.; Bargsten, Katja; Sáez-Calvo, Gonzalo; Jimeno, M. Luisa ; Benkhei, Mohammed; Ribatti, Domenico; Velázquez, Sonsoles ; Camarasa Rius, María José ; Díaz, José Fernando ; Steinmetz, Michel O.; Priego, Eva María ; Peréz-Pérez, María-Jesús ; Liekens, SandraArtículo
closedAccessrestringido.pdf.jpgJul-2008Apo-Hsp90 coexists in two open conformational states in solutionBron, P.; Giudice, E.; Rolland, J.P.; Martínez Buey, Rubén ; Barbier, Pascale; Díaz, José Fernando ; Peyrot, Vincent; Thomas, D.; Garnier, C.Artículo
closedAccess2007Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studiesLa Regina, Giuseppe; Edler, Michael C.; Brancale, Andrea; Kandil, Sahar; Coluccia, Antonio; Piscitelli, Francesco; Hamel, Ernest; De Martino, Gabriella; Matesanz, Ruth ; Díaz, José Fernando ; Scovassi, Anna Ivana; Prosperi, Ennio; Lavecchia, Antonio; Novellino, Ettore; Artico, Marino; Silvestri, RomanoArtículo
openAccessJ. Biol. Chem.-1998-D__az-33803-10.pdf.jpg11-Dec-1998Changes in microtubule protofilament number induced by Taxol binding to an easily accessible site. Internal microtubule dynamicsDíaz, José Fernando ; Valpuesta, Jose M.; Chacón, Pablo ; Diakun, Gregory P.; Andreu, José Manuel Artículo
closedAccess2007Characterizing Ligand-Microtubule binding by competition methodsDíaz, José Fernando ; Martínez Buey, Rubén Artículo
closedAccessaccesoRestringido.pdf.jpg2012Comparative Binding Energy (COMBINE) Analysis Supports a Proposal for the Binding Mode of Epothilones to β-TubulinCoderch, Claire; Klett, Javier ; Morreale, Antonio ; Díaz, José Fernando ; Gago, Federico Artículo
closedAccess16-May-2012Comparative Binding Energy (COMBINE) Analysis Supports a Proposal for the Binding Mode of Epothilones to -Tubulin.Coderch, Claire; Klett, Javier ; Morreale, Antonio ; Díaz, José Fernando ; Gago, Federico Artículo
embargoedAccessaccesoRestringido.pdf.jpg2018Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activityBueno, Oskía; Tobajas, Gloria; Quesada, Ernesto; Estévez-Gallego, Juan; Noppen, Sam; Camarasa Rius, María José ; Díaz, José Fernando ; Liekens, Sandra; Priego, Eva María ; Peréz-Pérez, María-Jesús Artículo
openAccessJ. Biol. Chem.-1998-Menéndez-167-76.pdf.jpg2-Jan-1998Control of the structural stability of the tubulin dimer by one high affinity bound magnesium ion at nucleotide N-siteMenéndez, Margarita ; Rivas, Germán ; Díaz, José Fernando ; Andreu, José Manuel Artículo
openAccessJ. Biol. Chem.-2010-Bustamante-33184-96.pdf.jpg22-Oct-2010Cpl-7, a Lysozyme Encoded by a Pneumococcal Bacteriophage with a Novel Cell Wall-Binding MotifBustamante, Noemí ; Campillo, Nuria E. ; García, Ernesto ; Gallego, Cristina; Pera, Benet ; Diakun, Gregory P.; Saiz, José L.; García, Pedro  ; Díaz, José Fernando ; Menéndez, Margarita Artículo
ijms-20-01392.pdf.jpg20-Mar-2019Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site LigandsBalaguer, Francisco de Asís; Mühlethaler, Tobias; Estévez Gallego, J.; Calvo, Enrique; Giménez-Abián, Juan F. ; Risinger, April L.; Sorensen, Erik J.; Vanderwal, Christopher D.; Altmann, Karl-Heinz; Mooberry, Susan; Steinmetz, Michel O.; Oliva, María A.; Prota, Andrea E.; Díaz, José Fernando Artículo
closedAccessaccesoRestringido.pdf.jpg30-Aug-2005Cyclostreptin (FR182877), an Antitumour Tubulin-Polymerizing Agent Deficient in Enhancing Tubulin Assembly Despite Its High Affinity for the Taxoid SiteEdler, Michael C.; Buey, Ruben M.; Gussio, Rick; Marcus, Adam I.; Vanderwal, Christopher D.; Sorensen, Erik J.; Díaz, José Fernando ; Giannakakou, Paraskevi; Hamel, ErnestArtículo
openAccesscyclostreptin_Buey.pdf.jpgJan-2007Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sitesBuey, Ruben M.; Calvo, Enrique; Barasoain, Isabel ; Pineda, Oriol; Edler, Michael C.; Matesanz, Ruth ; Cerezo, Gemma; Vanderwal, Christopher D.; Day, Billy W.; Sorensen, Erik J.; López, Juan Antonio; Andreu, José Manuel ; Hamel, Ernest; Díaz, José Fernando Artículo
closedAccessrestringido.pdf.jpgJan-2012Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel SiteCalvo, Enrique; Barasoain, Isabel ; Matesanz, Ruth ; Pera, Benet ; Camafeita, Emilio; Pineda, Oriol; Hamel, Ernest; Vanderwal, Christopher D.; Andreu, José Manuel ; López, Juan Antonio; Díaz, José Fernando Artículo
openAccessEBCAM_2015.pdf.jpg2015Cytotoxic activity and chemical composition of the root extract from the mexican species Linum scabrellum: mechanism of action of the active compound 6-MethoxypodophyllotoxinAlejandre-García, Ivonne; Álvarez, Laura ; Cardoso-Taketa, Alexandre; González-Maya, Leticia; Antúnez, Mayra; Salas-Vidal, Enrique; Díaz, José Fernando ; Marquina-Bahena, Silvia; Villarreal, María LuisaArtículo
openAccessncomms 2017.pdf.jpg9-Mar-2017Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic interventionBohnacker, Thomas; Díaz, José Fernando ; Wymann, Matthias P.Artículo
closedAccessMay-2011Design and Synthesis of Pironetin Analogues with Simplified Structure and Study of Their Interactions with MicrotubulesMarco, J. Alberto; García-Plab, Jorge; Carda, Miguel; Murga, Juan; Falomir, Eva; Trigili, Chiara ; Notararigo, Sara ; Díaz, José Fernando ; Barasoain, Isabel Artículo