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Browsing by Author Altmann, Karl-Heinz

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closedAccessaccesoRestringido.pdf.jpg12-Oct-2020A method for the stereoselective construction of the hemiaminal center in zampanolidesBrütsch, Tobias M.; Berardozzi, Simone; Rothe, Marlene L.; Redondo-Horcajo, Mariano CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinzartículo
openAccessijms-20-01392.pdf.jpg20-Mar-2019Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site LigandsBalaguer, Francisco de Asís; Mühlethaler, Tobias; Estévez-Gallego, Juan CSIC ORCID ; Calvo, Enrique; Giménez-Abián, Juan F. CSIC ; Risinger, April L.; Sorensen, Erik J.; Vanderwal, Christopher D.; Altmann, Karl-Heinz; Mooberry, Susan; Steinmetz, Michel O.; Oliva, María A. CSIC ORCID ; Prota, Andrea E.; Díaz, José Fernando CSIC ORCID artículo
closedAccessrestringido.pdf.jpg5-Oct-2009Epothilone Analogs with Benzimidazole and Quinoline Side Chains: Chemical Synthesis, Antiproliferative Activity, and Interactions with TubulinDietrich, Silvia Anthoine; Lindauer, Renate; Stierling, Claire; Gertsch, Jürg; Matesanz, Ruth CSIC ; Notararigo, Sara CSIC; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinzartículo
openAccessPera et al 2015.pdf.jpg1-Nov-2015High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cellsPera, Benet CSIC; Calvo, María Nieves; Ambati, Srikanth; Jordi, Michel; Kahn, Alissa; Díaz, José Fernando CSIC ORCID ; Fang, Wei-shuo S.; Altmann, Karl-Heinz; Cerchietti, ,Leandro; Moore, Malcolm A. S.artículo
openAccessNov-2021Maytansinol derivatives: side reactions as a chance for new tubulin bindersMarzullo, Paola; Boiarska, Zlata; Pérez-Peña, Helena; Abel, Anne-Catherine; Álvarez-Bernad, Beatriz; Lucena-Agell, Daniel CSIC ORCID ; Vasile, Francesca; Sironi, Maurizio; Altmann, Karl-Heinz; Prota, Andrea E.; Díaz, José Fernando CSIC ORCID ; Pieraccini, Stefano; Passarella, D.artículo
closedAccessrestringido.pdf.jpg1-Feb-2013Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer AgentsProta, Andrea E.; Bargsten, Katja; Zurwerra, Didier; Field, Jessica J.; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinz; Steinmetz, Michel O.artículo
openAccessImportance_Edenharter_Art2020.pdf.jpg2020On the Importance of the Thiazole Nitrogen in Epothilones: Semisynthesis and Microtubule-Binding Affinity of Deaza-Epothilone CEdenharter, Adriana; Ryckewaert, Lucie; Cintulová, Daniela; Estévez-Gallego, Juan CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinzartículo
openAccesspro98.pdf.jpg2011Shotgun and targeted MS analyses pinpoint the zampanolide-tubulin interacting siteCalvo, Enrique; Field, Jessica J.; Pera, Benet CSIC; Zuwera, D.; López, Juan Antonio; Camafeita, Emilio; Barasoain, Isabel CSIC ; Altmann, Karl-Heinz; Díaz, José Fernando CSIC ORCID póster de congreso
closedAccessaccesoRestringido.pdf.jpg26-Feb-2021Studies toward the synthesis of an oxazole-based analog of (−)-zampanolideBold, Christian Paul; Klaus, Cindy; Pfeiffer, Bernhard; Schürmann, Jasmine; Lombardi, Rafael; Lucena-Agell, Daniel CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinzartículo
closedAccessaccesoRestringido.pdf.jpg1-Apr-2021Synthesis of morpholine‐based analogues of (−)‐zampanolide and their biological activityBold, Christian Paul; Gut, Melanie; Schürmann, Jasmine; Lucena-Agell, Daniel CSIC ORCID ; Gertsch, Jürg; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinzartículo
openAccessmolecules-2016.pdf.jpg3-Aug-2016Synthesis, biological profiling and determination of the tubulin-bound conformation of 12-Aza-epothilones (azathilones)Jantsch, Andrea; Nieto, Lidia CSIC; Gertsch, Jürg; Rodríguez-Salarichs, Javier; Matesanz, Ruth CSIC ; Jiménez-Barbero, Jesús CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Canales, Ángeles CSIC ORCID; Altmann, Karl-Heinzartículo
openAccessmolecules-21-01010.pdf.jpg3-Aug-2016Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones)Jantsch, Andrea; Nieto, Lidia CSIC; Gertsch, Jürg; Rodríguez-Salarichs, Javier; Matesanz, Ruth CSIC ; Jiménez-Barbero, Jesús CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Canales, Ángeles CSIC ORCID; Altmann, Karl-Heinzartículo
openAccessijms-20-01113.pdf.jpg5-Mar-2019Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide ConjugateGaugaz, Fabienne Z.; Chicca, Andrea; Redondo-Horcajo, Mariano CSIC ORCID ; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinzartículo
closedAccessrestringido.pdf.jpg3-Apr-2019Synthesis, profiling, and bioactive conformation of trans-Cyclopropyl EpothilonesKuzniewski, Christian N.; Glauser, Simon; Gaugaz, Fabienne Z.; Schiess, Raphael; Rodríguez-Salarichs, Javier; Vetterli, Stefan; Horlacher, Oliver P.; Gertsch, Jürg; Redondo-Horcajo, Mariano CSIC ORCID ; Canales, Ángeles CSIC ORCID; Jiménez-Barbero, Jesús CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinzartículo
closedAccessaccesoRestringido.pdf.jpgOct-2014The impact of cyclopropane configuration on the biological activity of cyclopropyl-epothilonesGaugaz, Fabienne Z.; Redondo-Horcajo, Mariano CSIC ORCID ; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID ; Cobos-Correa, Amanda; Kaufmann, Markus; Altmann, Karl-Heinzartículo
closedAccessaccesoRestringido.pdf.jpg1-Jun-2011Zampanolida, un novedoso agente estabilizador de microtubulos quew se une covalentemente al sitio de paclitaxelField, Jessica J.; Pera, Benet CSIC; Canales, Ángeles CSIC ORCID; Zuwerra, D.; Trigili, Chiara CSIC; Kanakkanthara, Arun; Wakefield, St. John; Singh, A. Jonathan; Jiménez-Barbero, Jesús CSIC ORCID; Northcote, Peter; Miller, J.; López, Juan Antonio; Hamel, Ernest; Barasoain, Isabel CSIC ; Altmann, Karl-Heinz; Díaz, José Fernando CSIC ORCID póster de congreso
openAccessijms-18-00971-v2.pdf.jpg3-May-2017Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell MigrationField, Jessica J.; Northcote, Peter; Paterson, Ian; Altmann, Karl-Heinz; Díaz, José Fernando CSIC ORCID ; Miller, John H.artículo
openAccessField et al 2012_Chemistry and Biology.pdf.jpg22-Jun-2012Zampanolide, a potent new microtubule stabilizing agent, covalently reacts with the taxane luminal site in both tubulin alpha-beta-heterodimers and microtubulesField, Jessica J.; Pera, Benet CSIC; Calvo, Enrique; Canales, Ángeles CSIC ORCID; Zurwerra, Didier; Trigili, Chiara CSIC; Rodríguez-Salarichs, Javier; Matesanz, Ruth CSIC ; Kanakkanthara, Arun; Wakefield, St. John; Singh, A. Jonathan; Jiménez-Barbero, Jesús CSIC ORCID; Northcote, Peter; Miller, John H.; López, Juan Antonio; Hamel, Ernest; Barasoain, Isabel CSIC ; Altmann, Karl-Heinz; Díaz, José Fernando CSIC ORCID artículo