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closedAccessaccesoRestringido.pdf.jpg2020A new implication of quasispecies dynamics: Broad virus diversification in absence of external perturbationsDomingo, Esteban CSIC ORCID; Soria, María Eugenia; Gallego, I.; Ávila, Ana Isabel de; García-Crespo, Carlos; Martínez-González, Brenda; Gómez-Castilla, Jordi CSIC ORCID; Briones, Carlos CSIC ORCID; Gregori, J.; Quer, Josep; Perales, Celia CSIC ORCIDartículo de revisión
closedAccessaccesoRestringido.pdf.jpgDec-2020Amino acid substitutions associated with treatment failure for Hepatitis C virus infectionSoria, María Eugenia; García-Crespo, Carlos; Martínez-González, Brenda; Vázquez-Sirvent, Lucía; Lobo-Vega, Rebeca; Ávila, Ana Isabel de; Gallego, Isabel CSIC ORCID; Chen, Qian; García-Cehic, Damir; Llorens-Revull, Meritxell; Briones, Carlos CSIC ORCID; Gómez-Castilla, Jordi CSIC ORCID; Ferrer-Orta, Cristina CSIC ORCID ; Verdaguer, Núria CSIC ORCID ; Gregori, Josep; Rodríguez-Frías, Francisco; Buti, María; Esteban, Juan Ignacio; Domingo, Esteban CSIC ORCID; Quer, Josep; Perales, Celia CSIC ORCIDartículo
openAccessAmino acid substitutions_Soria_Congresos_Póster_2022.pdf.jpg6-Sep-2022Amino acid substitutions associated with treatment failure of hepatitis C virus infectionSoria, María Eugenia; García-Crespo, Carlos; Martínez-González, Brenda; Vázquez-Sirvent, Lucía; Lobo-Vega, Rebeca; Ávila, Ana Isabel de; Gallego, Isabel CSIC ORCID; Chen, Qian; García-Cehic, Damir; Llorens-Revull, Meritxell; Briones, Carlos CSIC ORCID; Gómez-Castilla, Jordi CSIC ORCID; Ferrer-Orta, Cristina CSIC ORCID ; Verdaguer, Núria CSIC ORCID ; Gregori, Josep; Rodríguez-Frías, Francisco; Buti, María; Esteban, Juan Ignacio; Domingo, Esteban CSIC ORCID; Quer, Josep; Perales, Celia CSIC ORCIDpóster de congreso
openAccesssomovilla-et-al-2023-atypical-mutational-spectrum-of-sars-cov-2-replicating-in-the-presence-of-ribavirin.pdf.jpg5-Jan-2023Atypical Mutational Spectrum of SARS-CoV-2 Replicating in the Presence of RibavirinSomovilla, Pilar; García-Crespo, Carlos; Martínez-González, Brenda; Soria, María Eugenia; Ávila, Ana Isabel de; Gallego, Isabel CSIC ORCID; Mínguez, Pablo; Durán-Pastor, Antoni; Ferrer-Orta, Cristina CSIC ORCID ; Salar-Vidal, Llanos; Esteban-Muñoz, Mario; Zúñiga Lucas, Sonia CSIC ORCID ; Solá Gurpegui, Isabel CSIC ORCID ; Enjuanes Sánchez, Luis CSIC ORCID ; Esteban, Jaime; Fernandez-Roblas, Ricardo; Gadea, Ignacio; Gómez-Castilla, Jordi CSIC ORCID; Verdaguer, Núria CSIC ORCID ; Domingo, Esteban CSIC ORCID; Perales, Celia CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg2020Broad and dynamic diversification of infectious hepatitis c virus in a cell culture environmentGallego, Isabel CSIC ORCID; Soria, María Eugenia; García-Crespo, Carlos; Chen, Q.; Martínez-Barragán, P.; Khalfaoui, S.; Martínez-González, Brenda; Sanchez-Martin, I.; Palacios-Blanco, Inés CSIC; Ávila, Ana Isabel de; García-Cehic, Damir; Esteban, Juan Ignacio; Gómez-Castilla, Jordi CSIC ORCID; Briones, Carlos CSIC ORCID; Gregori, Josep; Quer, Josep; Perales, Celia CSIC ORCID; Domingo, Esteban CSIC ORCIDartículo
openAccessMultifunctuional_poly-post-print.pdf.jpgOct-2018Contribution of a multifunctional polymerase region of foot-and-mouth disease virus to lethal mutagenesisHiguera, Ignacio de la CSIC ORCID; Ferrer-Orta, Cristina CSIC ORCID ; Moreno, Elena CSIC; Ávila, Ana Isabel de; Soria, María Eugenia; Singh, Kamalendra; Flavia Caridi,; Sobrino Castelló, Francisco CSIC ORCID; Sarafianos, Stefan G.; Perales, Celia CSIC ORCID; Verdaguer, Núria CSIC ORCID ; Domingo, Esteban CSIC ORCIDartículo
openAccessjcm-09-03450.pdf.jpg2020Dissimilar conservation pattern in hepatitis C virus mutant spectra, consensus sequences, and data banksGarcía-Crespo, Carlos; Soria, María Eugenia; Gallego, Isabel CSIC ORCID; Ávila, Ana Isabel de; Martínez-González, Brenda; Vázquez-Sirvent, Lucía; Gómez-Castilla, Jordi CSIC ORCID; Briones, Carlos CSIC ORCID; Gregori, Josep; Quer, Josep; Perales, Celia CSIC ORCID; Domingo, Esteban CSIC ORCIDartículo
openAccessEfficacy decrease_García_Crespo_PV_Art2022.pdf.jpg2022Efficacy decrease of antiviral agents when administered to ongoing hepatitis C virus infections in cell cultureGarcía-Crespo, Carlos; Vázquez-Sirvent, Lucía; Somovilla, Pilar; Soria, María Eugenia; Gallego, Isabel CSIC ORCID; Ávila, Ana Isabel de; Martínez-González, Brenda; Durán-Pastor, Antoni; Domingo, Esteban CSIC ORCID; Perales, Celia CSIC ORCIDartículo
openAccessGuanosine inhibits_Sabariegos_PV_Art2022.pdf.jpg2022Guanosine inhibits hepatitis C virus replication and increases indel frequencies, associated with altered intracellular nucleotide poolsSabariegos, Rosario; Ortega-Prieto, Ana M. CSIC ORCID; Díaz-Martínez, Luis; Grande-Pérez, Ana CSIC ORCID ; García-Crespo, Carlos; Gallego, Isabel CSIC ORCID; Ávila, Ana Isabel de; Albentosa González, Laura; Soria, María Eugenia; Gastaminza, Pablo CSIC ORCID; Domingo, Esteban CSIC ORCID; Perales, Celia CSIC ORCIDartículo
openAccessHepatitis_C_virus_García_PV_Art2023.pdf.jpg13-Mar-2023Hepatitis C virus fitness can influence the extent of infection-mediated epigenetic modifications in the host cellsGarcía-Crespo, Carlos; Francisco-Recuero, Irene CSIC ORCID; Gallego, Isabel CSIC ORCID; Camblor-Murube, Marina; Soria, María Eugenia; López-López, Ana; Ávila, Ana Isabel de; Madejón, Antonio; García-Samaniego, Javier; Domingo, Esteban CSIC ORCID; Sánchez-Pacheco, Aurora CSIC; Perales, Celia CSIC ORCIDartículo
openAccessMolecular_Higuera.pdf.jpg1-May-2017Molecular and functional bases of selection against a mutation bias in an RNA virusHiguera, Ignacio de la CSIC ORCID; Ferrer-Orta, Cristina CSIC ORCID ; Ávila, Ana Isabel de; Perales, Celia CSIC ORCID; Sierra, Macarena; Singh, Kamalendra; Sarafianos, Stefan G.; Dehouck, Yves; Bastolla, Ugo CSIC ORCID; Verdaguer, Núria CSIC ORCID ; Domingo, Esteban CSIC ORCIDartículo
openAccess2021Population Disequilibrium as Promoter of Adaptive Explorations in Hepatitis C VirusGarcía-Crespo, Carlos; Gallego, Isabel CSIC ORCID; Soria, María Eugenia; Ávila, Ana Isabel de; Martínez-González, Brenda; Vázquez-Sirvent, Lucía; Lobo-Vega, Rebeca; Moreno, Elena CSIC; Gómez-Castilla, Jordi CSIC ORCID; Briones, Carlos CSIC ORCID; Gregori, Josep; Quer, Josep; Domingo, Esteban CSIC ORCID; Perales, Celia CSIC ORCIDartículo de revisión
closedAccess21-Dec-2023Puzzles, challenges, and information reservoir of SARS-CoV-2 quasispeciesDomingo, Esteban CSIC ORCID; Martínez-González, Brenda; García-Crespo, Carlos; Somovilla, Pilar; Ávila, Ana Isabel de; Soria, María Eugenia; Durán-Pastor, Antoni; Perales, Celia CSIC ORCIDartículo de revisión
openAccesspathogens-11-00662-v2.pdf.jpg8-Jun-2022SARS-CoV-2 Mutant Spectra at Different Depth Levels Reveal an Overwhelming Abundance of Low Frequency MutationsMartínez-González, Brenda; Soria, María Eugenia; Vázquez-Sirvent, Lucía; Ferrer-Orta, Cristina CSIC ORCID ; Lobo-Vega, Rebeca; Mínguez, Pablo; Fuente, Lorena de la; Llorens, Carlos; Soriano, Beatriz; Ramos-Ruiz, Ricardo CSIC ORCID; Cortón, Marta; López-Rodríguez, Rosario; García-Crespo, Carlos; Somovilla, Pilar; Durán-Pastor, Antoni; Gallego, Isabel CSIC ORCID; Ávila, Ana Isabel de; Delgado, Soledad; Morán, Federico; López-Galíndez, Cecilio; Gómez-Castilla, Jordi CSIC ORCID; Enjuanes Sánchez, Luis CSIC ORCID ; Salar-Vidal, Llanos; Esteban-Muñoz, Mario; Esteban, Jaime; Fernández-Roblas, Ricardo; Gadea, Ignacio; Ayuso, Carmen; Ruíz-Hornillos, Javier; Verdaguer, Núria CSIC ORCID ; Domingo, Esteban CSIC ORCID; Perales, Celia CSIC ORCIDartículo
openAccessSARS-CoV-2 mutant spectra reveal_Martínez_Póster2022.pdf.jpg6-Sep-2022SARS-CoV-2 mutant spectra reveal differences between COVID-19 severity categoriesMartínez-González, Brenda; Soria, María Eugenia; Vázquez-Sirvent, Lucía; Ferrer-Orta, Cristina CSIC ORCID ; Lobo-Vega, Rebeca; Mínguez, Pablo; Fuente, Lorena de la; Llorens, Carlos; Soriano, Beatriz; Ramos-Ruiz, Ricardo CSIC ORCID; Cortón, Marta; López-Rodríguez, Rosario; García-Crespo, Carlos; Somovilla, Pilar; Durán-Pastor, Antoni; Gallego, Isabel CSIC ORCID; Ávila, Ana Isabel de; Delgado, Soledad; Morán, Federico; López-Galíndez, Cecilio; Gómez-Castilla, Jordi CSIC ORCID; Enjuanes Sánchez, Luis CSIC ORCID ; Salar-Vidal, Llanos; Esteban-Muñoz, Mario; Esteban, Jaime; Fernández-Roblas, Ricardo; Gadea, Ignacio; Ayuso, Carmen; Ruíz-Hornillos, Javier; Verdaguer, Núria CSIC ORCID ; Domingo, Esteban CSIC ORCID; Perales, Celia CSIC ORCIDpóster de congreso
openAccessspectrum.00221-22.pdf.jpg29-Mar-2022SARS-CoV-2 Point Mutation and Deletion Spectra and Their Association with Different Disease OutcomesMartínez-González, Brenda; Soria, María Eugenia; Vázquez-Sirvent, Lucía; Ferrer-Orta, Cristina CSIC ORCID ; Lobo-Vega, Rebeca; Mínguez, Pablo; Fuente, Lorena de la; Llorens, Carlos; Soriano, Beatriz; Ramos-Ruiz, Ricardo CSIC ORCID; Cortón, Marta; López-Rodríguez, Rosario; García-Crespo, Carlos; Gallego, Isabel CSIC ORCID; Ávila, Ana Isabel de; Gómez-Castilla, Jordi CSIC ORCID; Enjuanes Sánchez, Luis CSIC ORCID ; Salar-Vidal, Llanos; Esteban, Jaime; Fernández-Roblas, Ricardo; Gadea, Ignacio; Ayuso, Carmen; Ruíz-Hornillos, Javier; Verdaguer, Núria CSIC ORCID ; Domingo, Esteban CSIC ORCID; Perales, Celia CSIC ORCIDartículo
openAccessSARS-CoV-2 Point Mutation and Deletion Spectra.pdf.jpg12-Jan-2022SARS-CoV-2 Point Mutation and Deletion Spectra, and Their Association with Different Disease OutcomeMartínez-González, Brenda; Soria, María Eugenia; Vázquez-Sirvent, Lucía; Ferrer-Orta, Cristina CSIC ORCID ; Lobo-Vega, Rebeca; Mínguez, Pablo; Fuente, Lorena de la; Llorens, Carlos; Soriano, Beatriz; Ramos-Ruiz, Ricardo CSIC ORCID; Cortón, Marta; López-Rodríguez, Rosario; García-Crespo, Carlos; Gallego, Isabel CSIC ORCID; Ávila, Ana Isabel de; Gómez-Castilla, Jordi CSIC ORCID; Enjuanes Sánchez, Luis CSIC ORCID ; Salar-Vidal, Llanos; Esteban, Jaime; Fernández-Roblas, Ricardo; Gadea, Ignacio; Ayuso, Carmen; Ruíz-Hornillos, Javier; Verdaguer, Núria CSIC ORCID ; Domingo, Esteban CSIC ORCID; Perales, Celia CSIC ORCIDpreprint
openAccessDomingoE_TheIncreasingImpact.pdf.jpg30-Aug-2019The increasing impact of lethal mutagenesis of virusesPerales, Celia CSIC ORCID; Gallego, Isabel CSIC ORCID; Ávila, Ana Isabel de; Soria, María Eugenia; Gregori, Josep; Quer, Josep; Domingo, Esteban CSIC ORCIDartículo
openAccessVaccine breakthrough_Martínez_PV_Art2022.pdf.jpg2022Vaccine breakthrough infections with SARS-CoV-2 Alpha mirror mutations in Delta Plus, Iota, and OmicronMartínez-González, Brenda; Vázquez-Sirvent, Lucía; Soria, María Eugenia; Mínguez, Pablo; Salar-Vidal, Llanos; García-Crespo, Carlos; Gallego, Isabel CSIC ORCID; Ávila, Ana Isabel de; Llorens, Carlos; Soriano, Beatriz; Ramos-Ruiz, Ricardo CSIC ORCID; Esteban, Jaime; Fernández-Roblas, Ricardo; Gadea, Ignacio; Ayuso, Carmen; Ruíz-Hornillos, Javier; Pérez-Jorge, Concepción; Domingo, Esteban CSIC ORCID; Perales, Celia CSIC ORCIDartículo
openAccessPeralesC_ViralFitness-HistoryandRelevance.pdf.jpg13-Apr-2019Viral fitness: history and relevance for viral pathogenesis and antiviral interventionsDomingo, Esteban CSIC ORCID; Ávila, Ana Isabel de; Gallego, Isabel CSIC ORCID; Sheldon, Julie CSIC ORCID; Perales, Celia CSIC ORCIDartículo