Mostrando resultados 5 a 23 de 23
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| Derechos | Preview | Fecha Public. | Título | Autor(es) | Tipo |
| closedAccess |  | 5-oct-2009 | Epothilone Analogs with Benzimidazole and Quinoline Side Chains: Chemical Synthesis, Antiproliferative Activity, and Interactions with Tubulin | Dietrich, Silvia Anthoine; Lindauer, Renate; Stierling, Claire; Gertsch, Jürg; Matesanz, Ruth CSIC ; Notararigo, Sara CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinz | artículo |
| openAccess |  | 1-nov-2015 | High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells | Pera, Benet CSIC; Calvo, María Nieves; Ambati, Srikanth; Jordi, Michel; Kahn, Alissa; Díaz, José Fernando CSIC ORCID ; Fang, Wei-Shuo; Altmann, Karl-Heinz; Cerchietti, ,Leandro; Moore, Malcolm A. S. | artículo |
| openAccess |  | nov-2021 | Maytansinol derivatives: side reactions as a chance for new tubulin binders | Marzullo, Paola; Boiarska, Zlata; Pérez-Peña, Helena; Abel, Anne-Catherine; Álvarez-Bernad, Beatriz CSIC; Lucena-Agell, Daniel CSIC ORCID ; Vasile, Francesca; Sironi, Maurizio; Altmann, Karl-Heinz; Prota, Andrea E.; Díaz, José Fernando CSIC ORCID ; Pieraccini, Stefano; Passarella, D. | artículo |
| closedAccess |  | 1-feb-2013 | Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents | Prota, Andrea E.; Bargsten, Katja; Zurwerra, Didier; Field, Jessica J.; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinz; Steinmetz, Michel O. | artículo |
| openAccess |  | 2020 | On the Importance of the Thiazole Nitrogen in Epothilones: Semisynthesis and Microtubule-Binding Affinity of Deaza-Epothilone C | Edenharter, Adriana; Ryckewaert, Lucie; Cintulová, Daniela; Estévez-Gallego, Juan CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinz | artículo |
| openAccess |  | 2011 | Shotgun and targeted MS analyses pinpoint the zampanolide-tubulin interacting site | Calvo, Enrique; Field, Jessica J.; Pera, Benet CSIC; Zuwerra, D.; López, Juan Antonio; Camafeita, Emilio; Barasoain, Isabel CSIC ; Altmann, Karl-Heinz; Díaz, José Fernando CSIC ORCID | póster de congreso |
| openAccess |  | 6-mar-2023 | Structural insight into the stabilization of microtubules by taxanes | Prota, Andrea E.; Lucena-Agell, Daniel CSIC ORCID ; Ma, Yuntao; Estévez-Gallego, Juan CSIC ORCID ; Li, Shuo; Bargsten, Katja; Josa-Prado, Fernando CSIC ORCID; Altmann, Karl-Heinz; Gaillard, Natacha; Kamimura, Shinji; Mühlethaler, Tobias; Gago, Federico CSIC ORCID; Oliva, María A. CSIC ORCID ; Steinmetz, Michel O.; Fang, Wei-Shuo; Díaz, José Fernando CSIC ORCID | artículo |
| closedAccess |  | 26-feb-2021 | Studies toward the synthesis of an oxazole-based analog of (−)-zampanolide | Bold, Christian Paul; Klaus, Cindy; Pfeiffer, Bernhard; Schürmann, Jasmine; Lombardi, Rafael; Lucena-Agell, Daniel CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinz | artículo |
| openAccess |  | 25-oct-2022 | Synthesis and biological evaluation of C(13)/C(13′)-Bis(desmethyl)disorazole Z** | Bold, Christian Paul; Lucena-Agell, Daniel CSIC ORCID ; Oliva, María A. CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinz | artículo |
| openAccess |  | 2023 | Synthesis and structure-activity relationship studies of C(13)-desmethylene-(−)-zampanolide analogs | Brütsch, Tobias M.; Cotter, Etienne; Lucena-Agell, Daniel CSIC ORCID ; Redondo-Horcajo, Mariano CSIC ORCID ; Davies, Carolina; Pfeiffer, Bernhard; Pagani, Sandro; Berardozzi, Simone; Díaz, José Fernando CSIC ORCID ; Miller, John H.; Altmann, Karl-Heinz | artículo |
| closedAccess |  | 1-abr-2021 | Synthesis of morpholine‐based analogues of (−)‐zampanolide and their biological activity | Bold, Christian Paul; Gut, Melanie; Schürmann, Jasmine; Lucena-Agell, Daniel CSIC ORCID ; Gertsch, Jürg; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinz | artículo |
| openAccess |  | 3-ago-2016 | Synthesis, biological profiling and determination of the tubulin-bound conformation of 12-Aza-epothilones (azathilones) | Jantsch, Andrea; Nieto, Lidia CSIC; Gertsch, Jürg; Rodríguez-Salarichs, Javier CSIC; Matesanz, Ruth CSIC ; Jiménez-Barbero, Jesús CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Canales, Ángeles CSIC ORCID; Altmann, Karl-Heinz | artículo |
| openAccess |  | 5-mar-2019 | Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate | Gaugaz, Fabienne Z.; Chicca, Andrea; Redondo-Horcajo, Mariano CSIC ORCID ; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinz | artículo |
| closedAccess |  | 3-abr-2019 | Synthesis, profiling, and bioactive conformation of trans-Cyclopropyl Epothilones | Kuzniewski, Christian N.; Glauser, Simon; Gaugaz, Fabienne Z.; Schiess, Raphael; Rodríguez-Salarichs, Javier CSIC; Vetterli, Stefan; Horlacher, Oliver P.; Gertsch, Jürg; Redondo-Horcajo, Mariano CSIC ORCID ; Canales, Ángeles CSIC ORCID; Jiménez-Barbero, Jesús CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinz | artículo |
| closedAccess |  | mar-2020 | Taxanes convert regions of perturbed microtubule growth into rescue sites | Rai, Ankit; Liu, Tianyang; Glauser, Simon; Katrukha, Eugene A.; Estévez-Gallego, Juan CSIC ORCID ; Rodríguez-García, Ruddi; Fang, Wei-Shuo; Díaz, José Fernando CSIC ORCID ; Steinmetz, Michel O.; Altmann, Karl-Heinz; Kapitein, Lukas C.; Moores, Carolyn A.; Akhmanova, Anna | artículo |
| closedAccess |  | oct-2014 | The impact of cyclopropane configuration on the biological activity of cyclopropyl-epothilones | Gaugaz, Fabienne Z.; Redondo-Horcajo, Mariano CSIC ORCID ; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID ; Cobos-Correa, Amanda; Kaufmann, Markus; Altmann, Karl-Heinz | artículo |
| closedAccess |  | 1-jun-2011 | Zampanolida, un novedoso agente estabilizador de microtubulos quew se une covalentemente al sitio de paclitaxel | Field, Jessica J.; Pera, Benet CSIC; Canales, Ángeles CSIC ORCID; Zuwerra, D.; Trigili, Chiara CSIC; Kanakkanthara, Arun; Wakefield, St. John; Singh, A. Jonathan; Jiménez-Barbero, Jesús CSIC ORCID; Northcote, Peter; Miller, J.; López, Juan Antonio; Hamel, Ernest; Barasoain, Isabel CSIC ; Altmann, Karl-Heinz; Díaz, José Fernando CSIC ORCID | póster de congreso |
| openAccess |  | 3-may-2017 | Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration | Field, Jessica J.; Northcote, Peter; Paterson, Ian; Altmann, Karl-Heinz; Díaz, José Fernando CSIC ORCID ; Miller, John H. | artículo |
| openAccess |  | 22-jun-2012 | Zampanolide, a potent new microtubule stabilizing agent, covalently reacts with the taxane luminal site in both tubulin alpha-beta-heterodimers and microtubules | Field, Jessica J.; Pera, Benet CSIC; Calvo, Enrique; Canales, Ángeles CSIC ORCID; Zurwerra, Didier; Trigili, Chiara CSIC; Rodríguez-Salarichs, Javier CSIC; Matesanz, Ruth CSIC ; Kanakkanthara, Arun; Wakefield, St. John; Singh, A. Jonathan; Jiménez-Barbero, Jesús CSIC ORCID; Northcote, Peter; Miller, John H.; López, Juan Antonio; Hamel, Ernest; Barasoain, Isabel CSIC ; Altmann, Karl-Heinz; Díaz, José Fernando CSIC ORCID | artículo |
