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openAccessNature Communications_Menchon_2018.pdf.jpg29-may-2018A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulinMenchon, Grégory; Lucena-Agell, Daniel CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Steinmetz, Michel O.artículo
closedAccessaccesoRestringido.pdf.jpg12-oct-2020A method for the stereoselective construction of the hemiaminal center in zampanolidesBrütsch, Tobias M.; Berardozzi, Simone; Rothe, Marlene L.; Redondo-Horcajo, Mariano CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinzartículo
openAccesstubulin_binding_Coderch.pdf.jpgmar-2013A structure-based design of new C2- and C13-substituted taxanes: Tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysisCoderch, Claire; Tang, Yong; Klett, Javier CSIC ORCID; Zhang, Shu-En; Ma, Yung-Tao; Shaorong, Wang; Matesanz, Ruth CSIC ; Pera, Benet CSIC; Canales, Ángeles CSIC ORCID; Jiménez-Barbero, Jesús CSIC ORCID; Morreale, Antonio; Díaz, José Fernando CSIC ORCID ; Fang, Wei-shuo S.; Gago, Federico CSIC ORCIDartículo
openAccessJ. Biol. Chem.-2001-D__az-17307-15.pdf.jpg18-may-2001Activation of cell division protein FtsZ. Control of switch loop T3 conformation by the nucleotide gamma-phosphateDíaz, José Fernando CSIC ORCID ; Kralicek, Andrew; Mingorance, Jesús CSIC ORCID; Palacios, Juan Manuel; Vicente, Miguel CSIC ORCID; Andreu, José Manuel CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg26-ago-2016Aggregated compound biological signatures facilitate phenotypic drug discovery and target elucidationCortés Cabrera, Álvaro CSIC ORCID; Lucena-Agell, Daniel CSIC ORCID ; Redondo-Horcajo, Mariano CSIC ORCID ; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID ; Fasching, Bernhard; Petrone, Paula M.artículo
openAccessacsomega_oliva_2023.pdf.jpg13-ene-2023Alternative approaches to understand microtubule cap morphology and functionOliva, María A. CSIC ORCID ; Gago, Federico CSIC ORCID; Kamimura, Shinji; Díaz, José Fernando CSIC ORCID artículo
openAccessOncotarget.pdf.jpg20-may-2016Antivascular and antitumor properties of the tubulin-binding chalcone TUB091Canela, María-Dolores CSIC; Noppen, Sam; Bueno, Oskia CSIC; Prota, Andrea E.; Bargsten, Katja; Sáez-Calvo, Gonzalo CSIC; Jimeno, M. Luisa CSIC ORCID; Benkhei, Mohammed; Ribatti, Domenico; Velázquez, Sonsoles CSIC ORCID CVN; Camarasa Rius, María José CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Steinmetz, Michel O.; Priego, Eva María CSIC ORCID; Peréz-Pérez, María-Jesús CSIC ORCID ; Liekens, Sandraartículo
closedAccessrestringido.pdf.jpgjul-2008Apo-Hsp90 coexists in two open conformational states in solutionBron, P.; Giudice, E.; Rolland, J.P.; Martínez Buey, Rubén CSIC ORCID; Barbier, Pascale; Díaz, José Fernando CSIC ORCID ; Peyrot, Vincent; Thomas, D.; Garnier, Cyrilleartículo
closedAccess2007Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studiesLa Regina, Giuseppe; Edler, Michael C.; Brancale, Andrea; Kandil, Sahar; Coluccia, Antonio; Piscitelli, Francesco; Hamel, Ernest; De Martino, Gabriella; Matesanz, Ruth CSIC ; Díaz, José Fernando CSIC ORCID ; Scovassi, Anna Ivana; Prosperi, Ennio; Lavecchia, Antonio; Novellino, Ettore; Artico, Marino; Silvestri, Romanoartículo
closedAccessaccesoRestringido.pdf.jpg15-mar-2018Au@p4VP core@shell pH-sensitive nanocomposites suitable for drug entrapmentClara-Rahola, Joaquim; Moscoso, Ana; Ruiz-Muelle, Ana Belén; Laurenti, Marco; Formanek, Petr; Lopez-Romero, Juan M.; Fernández, Ignacio CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Rubio-Retama, Jorge; Fery, A.; Contreras-Cáceres, Rafaelartículo
openAccessJ. Biol. Chem.-1998-D__az-33803-10.pdf.jpg11-dic-1998Changes in microtubule protofilament number induced by Taxol binding to an easily accessible site. Internal microtubule dynamicsDíaz, José Fernando CSIC ORCID ; Valpuesta, José M. CSIC ORCID ; Chacón, Pablo CSIC ORCID; Diakun, Gregory P.; Andreu, José Manuel CSIC ORCID artículo
closedAccess2007Characterizing Ligand-Microtubule binding by competition methodsDíaz, José Fernando CSIC ORCID ; Martínez Buey, Rubén CSIC ORCIDartículo
openAccessene-2023Chemical modulation of microtubule structure as a tool to target different diseasesEstévez-Gallego, Juan CSIC ORCID ; Álvarez-Bernad, Beatriz CSIC; Lucena-Agell, Daniel CSIC ORCID ; Bonato, Francesca CSIC ORCID; Giménez-Abián, Juan F. CSIC ; Blanco, Óscar; París, Rebeca; Fuertes, L.; Martínez, J. C.; Kamimura, Shinji; Gago, Federico CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Oliva, María A. CSIC ORCID comunicación de congreso
openAccessStructure_Estévez-Gallego_2022.pdf.jpg5-ene-2023Chemical modulation of microtubule structure through the laulimalide/peloruside siteEstévez-Gallego, Juan CSIC ORCID ; Álvarez-Bernad, Beatriz CSIC; Benet, Pera; Wullschleger, Christoph; Raes, Olivier; Menche, Dirk; Martínez, Juan Carlos; Lucena-Agell, Daniel CSIC ORCID ; Prota, Andrea E.; Bonato, Francesca CSIC ORCID; Bargsten, Katja; Cornelus, Jelle; Giménez-Abián, Juan F. CSIC ; Northcote, Peter; Steinmetz, Michel O.; Kamimura, Shinji; Altmann, Karl-Heinz; Paterson, Ian; Gago, Federico CSIC ORCID; Van der Eycken, Johan; Díaz, José Fernando CSIC ORCID ; Oliva, María A. CSIC ORCID artículo
openAccessCHLOROACETYLATION OF CYCLOSTREPTIN INFLUENCES.pdf.jpg2009Chloroacetylation of cyclostreptin influences its interaction with tubulinCalvo, Enrique; Barasoain, Isabel CSIC ; Camafeita, Emilio; Andreu, José Manuel CSIC ORCID ; López, Juan Antonio; Díaz, José Fernando CSIC ORCID comunicación de congreso
openAccessDevelopemental Cell_2021_ Thakkar paper.pdf.jpg6-dic-2021CLIP-170S is a microtubule +TIP variant that confers resistance to taxanes by impairing drug-target engagementThakkar, Prashant V.; Kita, Katsuhiro; Del Castillo, Urko; Galletti, Giuseppe; Madhukar, Neel; Vila Navarro, Elena; Barasoain, Isabel CSIC ; Goodson, Holly V.; Sackett, Dan L.; Díaz, José Fernando CSIC ORCID ; Lu, Yao CSIC ORCID; RoyChoudhary, Arindam; Molina, Henrik; Elemento, Olivier; Shah, Manish A.; Giannakakou, Paraskeviartículo
closedAccessaccesoRestringido.pdf.jpg2012Comparative Binding Energy (COMBINE) Analysis Supports a Proposal for the Binding Mode of Epothilones to β-TubulinCoderch, Claire; Klett, Javier CSIC ORCID; Morreale, Antonio; Díaz, José Fernando CSIC ORCID ; Gago, Federico CSIC ORCIDartículo
openAccessaccesoRestringido.pdf.jpg2018Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activityBueno, Oskia CSIC; Tobajas, Gloria; Quesada, Ernesto CSIC ORCID ; Estévez-Gallego, Juan CSIC ORCID ; Noppen, Sam; Camarasa Rius, María José CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Liekens, Sandra; Priego, Eva María CSIC ORCID; Peréz-Pérez, María-Jesús CSIC ORCID artículo
openAccessJ. Biol. Chem.-1998-Menéndez-167-76.pdf.jpg2-ene-1998Control of the structural stability of the tubulin dimer by one high affinity bound magnesium ion at nucleotide N-siteMenéndez, Margarita CSIC ORCID; Rivas, Germán CSIC ORCID CVN ; Díaz, José Fernando CSIC ORCID ; Andreu, José Manuel CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg14-jun-2011Corrigendum: Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and JTrigili, Chiara CSIC; Pera, Benet CSIC; Barbazanges, Marion; Cossy, Janine; Meyer, Christophe; Pineda, Oriol; Rodríguez-Escrich, Carles; Urpí, Félix; Vilarrasa, Jaume; Díaz, José Fernando CSIC ORCID ; Barasoain, Isabel CSIC corrigenda