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openAccess2020 Int J Mol Sci 021-04096.pdf.jpg8-jun-2020Reactive Glia Inflammatory Signaling Pathways and EpilepsySanz, Pascual CSIC ORCID ; García-Gimeno, María Adelaida CSIC ORCIDrevisión
openAccess2020 Mol Neurobiol 57-1607 vers aut.pdf.jpgmar-2020Reactive Glia-Derived Neuroinflammation: a Novel Hallmark in Lafora Progressive Myoclonus Epilepsy That Progresses with AgeLahuerta, Marcos CSIC; Gonzalez, Daymé; Aguado, Carmen; Fathinajafabadi, Alihamze; García-Giménez, José Luis; Moreno-Estellés, Mireia CSIC ORCID; Romá-Mateo, Carlos CSIC ORCID CVN; Knecht, Erwin; Pallardó, Federico V.; Sanz, Pascual CSIC ORCID artículo
openAccessglycogen_synthesis_Solaz.pdf.jpg1-mar-2008Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathwaySolaz-Fuster, Maria Carmen CSIC; Gimeno-Alcañiz, José Vicente; Ros, Susana; Fernández-Sánchez, Maria Elena CSIC; García-Fojeda, Belén CSIC ORCID; Criado-García, Olga CSIC ORCID ; Vilchez, David; Domínguez, Jorge; Ros, Susana; García-Rocha, Mar; Sánchez-Piris, Maribel CSIC; Aguado, Carmen; Knecht, Erwin; Serratosa, José María; Sanz, Pascual CSIC ORCID ; Rodríguez de Córdoba, Santiago artículo
openAccess2020 Biochim Biophys Acta Mol Cell Res 1867-118613 vers aut.pdf.jpgfeb-2020Regulation of the autophagic PI3KC3 complex by laforin/malin E3-ubiquitin ligase, two proteins involved in Lafora diseaseSánchez-Martín, Pablo CSIC ORCID; Lahuerta, Marcos CSIC; Viana, Rosa CSIC ORCID ; Knecht, Erwin; Sanz, Pascual CSIC ORCID artículo
openAccess2008 BBRC 369-964.pdf.jpg9-may-2008Role of AMP-activated protein kinase in autophagy and proteasome functionViana, Rosa CSIC ORCID ; Aguado, Carmen; Esteban, Inmaculada; Moreno, Daniel; Viollet, Benoit; Knecht, Erwin; Sanz, Pascual CSIC ORCID artículo
openAccessWO2017098073A1.pdf.jpg15-jun-2017Spiranic derivative compounds of oxindole-pirazolo[3,4-b]pyridinone and therapeutic uses thereofCastro, Ana CSIC ORCID; Sanz, Pascual CSIC ORCID ; Quesada Sánchez, Sergio CSIC; García Gimeno, María Adelaida; Luque Garriga, Francisco Javier; Bidon-Chanal Badia, Axelsolicitud de patente
openAccess2015 Plos One 010-e0131476.pdf.jpg26-jun-2015Structure-Function Analysis of PPP1R3D, a Protein Phosphatase 1 Targeting Subunit, Reveals a Binding Motif for 14-3-3 Proteins which Regulates its Glycogenic PropertiesRubio-Villena, Carla CSIC ORCID; Sanz, Pascual CSIC ORCID ; García-Gimeno, María Adelaida CSIC ORCIDartículo
closedAccessago-2005Structure—function analysis of the α5 and the α13 helices of human glucokinase: Description of two novel activating mutationsPedelini, Leda CSIC ORCID; García-Gimeno, María Adelaida CSIC ORCID; Marina, Alberto CSIC ORCID ; Gomez-Zumaquero, Juan M.; Rodriguez-Bada, Pablo; López-Enríquez, Soledad CSIC ORCID; Soriguer, Federico C.; Cuesta-Muñoz, Antonio L.; Sanz, Pascual CSIC ORCID artículo
openAccess2016 PLoS ONE 011-e0163898.pdf.jpg3-oct-2016Studying Closed Hydrodynamic Models of "In Vivo" DNA Perfusion in Pig Liver for Gene Therapy Translation to Humans.Sendra, Luis; Miguel, Antonio; Pérez-Enguix, Daniel; Herrero, María José CSIC ORCID; Montalvá, Eva; García-Gimeno, María Adelaida CSIC ORCID; Noguera, Inmaculada; Díaz, Ana; Pérez, Judith; Sanz, Pascual CSIC ORCID ; López-Andújar, Rafael; Martí-Bonmatí, Luis; Aliño, Salvador F.artículo
openAccess2013 Mol Biol Cell 24-1801.pdf.jpg3-abr-2013Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activityRubio, Teresa CSIC ORCID; Vernia, Santiago CSIC ORCID ; Sanz, Pascual CSIC ORCID artículo
openAccess2020 Pharmacol Res 161-105105.pdf.jpg30-jul-2020Synergistic activation of AMPK prevents from polyglutamine-inducedtoxicity inCaenorhabditis elegansGómez-Escribano, A. P.; Bono-Yagüe, J.; García-Gimeno, María Adelaida CSIC ORCID; Sequedo, M. D.; Hervás, D.; Fornés-Ferrer, Victoria; Torres-Sánchez, S. C.; Millán, J. M.; Sanz, Pascual CSIC ORCID ; Vázquez-Manrique, Rafael P. CSIC ORCIDartículo
openAccess2020 Epilepsy Behav 103-106839 vers aut.pdf.jpgfeb-2020The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinicGentry, Matthew S.; Afawi, Zaid; Armstrong, Dustin D.; Delgado-Escueta, Antonio; Goldberg, Y. Paul; Grossman, Tamar R.; Guinovart, Joan J.; Harris, Frank; Hurley, Thomas D.; Michelucci, Roberto; Minassian, Berge A.; Sanz, Pascual CSIC ORCID ; Worby, Carolyn A.; Serratosa, Jose M.actas de congreso
openAccess2016 Biochem J 473-00937manuscript.pdf.jpg1-feb-2016The interaction between AMPKβ2 and the PP1-targeting subunit R6 is dynamically regulated by intracellular glycogen contentOligschlaeger, Yvonne; Miglianico, Marie; Dahlmans, Vivian; Rubio-Villena, Carla CSIC ORCID; Chanda, Dipanjan; García-Gimeno, María Adelaida CSIC ORCID; Coumans, Will A.; Liu, Yilin; Voncken, Jan Willem; Luiken, Joost J.F.P.; Glatz, Jan F.C.; Sanz, Pascual CSIC ORCID ; Neumann, Dietbertartículo
openAccess12858_2015_Article_53.pdf.jpg23-oct-2015The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2Viana, Rosa CSIC ORCID ; Luján, Pablo CSIC; Sanz, Pascual CSIC ORCID artículo
openAccessMol Biol Cell 021-02578 2010.pdf.jpg9-jun-2010The Laforin–Malin Complex, Involved in Lafora Disease, Promotes the Incorporation of K63-linked Ubiquitin Chains into AMP-activated Protein Kinase β SubunitsMoreno Andrés, Daniel CSIC; Towler, Mhairi; Hardie, D. Grahame; Knecht, Erwin; Sanz, Pascual CSIC ORCID artículo
openAccess2023 Neurobiol Dis 176-105964.pdf.jpgene-2023TNF and IL6/Jak2 signaling pathways are the main contributors of the glia-derived neuroinflammation present in Lafora disease, a fatal form of progressive myoclonus epilepsyRubio, Teresa CSIC ORCID; Viana, Rosa CSIC ORCID ; Moreno-Estellés, Mireia CSIC ORCID; Campos, Ángela CSIC; Sanz, Pascual CSIC ORCID artículo
openAccess2016 Sanz Lafora WS ComunOral.pdf.jpg24-mar-2016Towards the understanding of the molecular basis of epilepsy in Lafora diseaseMuñoz-Ballester, Carmen CSIC ORCID; Viana, Rosa CSIC ORCID ; Heredia, Miguel CSIC; López-González, Irene; Ferrer, lsidre; Sanz, Pascual CSIC ORCID comunicación de congreso
openAccess2021 Cells 10-00820.pdf.jpg6-abr-2021TRIM32 and Malin in Neurological and Neuromuscular Rare DiseasesKumarasinghe, Lorena CSIC ORCID; Xiong, Lu CSIC; García-Gimeno, María Adelaida CSIC ORCID; Lazzari, Elisa; Sanz, Pascual CSIC ORCID ; Meroni, Germanaartículo
openAccess2009 Int. J. Biochem Cell Biol 41-2341.pdf.jpgdic-2009Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinaseMoreno, Daniel; Viana, Rosa CSIC ORCID ; Sanz, Pascual CSIC ORCID artículo
openAccess2015 IJBCB 69-204.pdf.jpg3-nov-2015Ubiquitin conjugating enzyme E2-N and sequestosome-1 (p62) are components of the ubiquitination process mediated by the malin-laforin E3-ubiquitin ligase complexSánchez-Martín, Pablo CSIC ORCID; Romá-Mateo, Carlos CSIC ORCID CVN; Viana, Rosa CSIC ORCID ; Sanz, Pascual CSIC ORCID artículo