Showing results 1 to 20 of 38
next >
Rights | Preview | Issue Date | Title | Author(s) | Type |
openAccess |  | 5-May-2011 | 1,8-Naphthyridine-devired compounds and the use thereof in the treatment of neurodegenerative diseases | Ríos Salgado, Cristóbal; Romero Martínez, Alejandro; Egea Maiquez, Javier; León, Rafael CSIC ORCID ; Villarroya Sánchez, Mercedes; García López, Manuela; García García, Antonio; Marco-Contelles, José CSIC ORCID; Soriano, Elena CSIC; Samadi, Abdelouahid CSIC ORCID; Chioua, Mourad CSIC ORCID | artículo |
closedAccess |  | 2012 | Benzothiazepine CGP37157 and its isosteric 2′-ethyl analogue provide neuroprotection and block cell calcium entry | González-Lafuente, Laura; Egea, Javier; León, Rafael CSIC ORCID ; Martínez-Sanz, Francisco J.; Monjas, Leticia CSIC ORCID; Pérez, Concepción; Merino, Cristina; García-De Diego. Antonio M.; Rodríguez-Franco, María Isabel CSIC ORCID ; García, Antonio G.; Villarroya, Mercedes; López, Manuela G.; Ríos, Cristóbal de los | artículo |
openAccess |  | 2021 | Bisavenathramide analogues as nrf2 inductors and neuroprotectors in in vitro models of oxidative stress and hyperphosphorylation | Cores, Ángel; Abril, S.; Michalska, Patrycja; Duarte, Pablo; Olives, A. I.; Martín, M. A.; Villacampa, Mercedes; León, Rafael CSIC ORCID ; Menéndez, José Carlos | artículo |
openAccess |  | 1-Jun-2011 | Compuestos derivados de 1,8-naftiridinas y su uso en el tratamiento de enfermedades neurodegenerativas | Romero Martínez, Alejandro; García García, Antonio; García López, Manuela; Egea Maiquez, Javier; Chioua, Mourad CSIC ORCID ; Villarroya Sánchez, Mercedes; Soriano, Elena CSIC; León, Rafael CSIC ORCID ; Marco-Contelles, José CSIC ORCID; Ríos Salgado, Cristóbal; Samadi, Abdelouahid CSIC ORCID | solicitud de patente |
openAccess |  | 2022 | Curcumin-piperlongumine hybrids with a multitarget profile elicit neuroprotection in in vitro models of oxidative stress and hyperphosphorylation | Cores, Ángel; Carmona-Zafra, Noelia; Martín-Cámara, Olmo; Sánchez, Juan Domingo; Duarte, Pablo; Villacampa, Mercedes; Bermejo-Bescós, Paloma; Martín-Aragón, Sagrario; León, Rafael CSIC ORCID ; Menéndez, José Carlos | artículo |
openAccess |  | 2017 | Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease | Gameiro, Isabel; Michalska, Patrycja; Tenti, Giammarco; Cores, Ángel; Buendía Abaitua, Izaskun; Rojo, Ana I. CSIC ORCID; Georgakopoulos, Nikolaos D.; Hernández, Jesús M. CSIC ORCID ; Ramos, María Teresa; Wells, Geoffrey; López, Manuela G.; Cuadrado, Antonio CSIC ORCID; Menéndez, Carlos; León, Rafael CSIC ORCID | artículo |
openAccess |  | 4-Jan-2022 | Enantioselective Synthesis and Pharmacological Evaluation of Aza-CGP37157–Lipoic Acid Hybrids for the Treatment of Alzheimer’s Disease | Cores, Ángel; Michalska, Patrycja; Pérez, José Miguel; Crisman, Enrique; Gómez, Clara; Villacampa, Mercedes; Menéndez, José Carlos; León, Rafael CSIC ORCID | artículo |
openAccess |  | 2021 | Enhanced stability and bioactivity of natural anticancer topoisomerase i inhibitors through cyclodextrin complexation | González-Ruiz, Victor; Cores, Ángel; Martín-Cámara, Olmo; Orellana, K.; Cervera-Carrascón, V.; Michalska, Patrycja; Olives, A. I.; León, Rafael CSIC ORCID ; Martín, M. A.; Menéndez, José Carlos | artículo |
openAccess |  | 2017 | Enzymatic and solid-phase synthesis of new donepezil-based L- and D-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia | Monjas, Leticia CSIC ORCID; Arce, Mariana P. CSIC; León, Rafael CSIC ORCID ; Egea, Javier; Pérez, Concepción; Villarroya, Mercedes; López, Manuela G.; Gil, Carmen CSIC ORCID ; Conde, Santiago; Rodríguez-Franco, María Isabel CSIC ORCID | artículo |
openAccess |  | Sep-2020 | Geochemical behavior of rare earth elements in acid drainages: Modeling achievements and limitations | Lozano, Alba; Ayora, Carlos CSIC ORCID; Macías, Francisco; Gimeno, María José; León, Rafael CSIC ORCID ; Auqué, Luis | artículo |
closedAccess |  | 21-May-2020 | Impact of KPC Production and High-Level Meropenem Resistance on All-Cause Mortality of Ventilator-Associated Pneumonia in Association with Klebsiella pneumoniae | Rivera-Espinar, Francisco; Machuca, Isabel; Tejero, Rocío; Rodríguez, Jorge; Mula, Ana; Marfil-Pérez, Eduardo; Cano, Ángela; Gutiérrez-Gutiérrez, Belén CSIC ORCID; Rodríguez, Marina; Pozo, Juan Carlos; Fuente, Carmen de la; Rodríguez-Baño, Jesús CSIC ORCID; Martínez-Martínez, Luis; León, Rafael CSIC ORCID ; Torre-Cisneros, Julián | artículo |
openAccess |  | 2022 | KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential | Crisman, Enrique; Duarte, Pablo; Dauden, Esteban; Cuadrado,Antonio; Rodríguez-Franco, María Isabel CSIC ORCID ; López,Manuela G.; León, Rafael CSIC ORCID | artículo |
closedAccess |  | 2020 | Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization | Michalska, Patrycja; Buendía Abaitua, Izaskun; Duarte, Pablo; Fernández-Mendívil, Cristina; Negredo, Pilar; Cuadrado, Antonio CSIC ORCID; López, Manuela G.; León, Rafael CSIC ORCID | artículo |
embargoedAccess |  | May-2021 | Mine waters as a secondary source of rare earth elements worldwide: The case of the Iberian Pyrite Belt | León, Rafael CSIC ORCID ; Macías, Francisco; Cánovas, Carlos R.; Pérez-López, Rafael; Ayora, Carlos CSIC ORCID; Nieto, José Miguel; Olías, Manuel | artículo |
closedAccess |  | 2021 | Monoamine Oxidase Inhibitors: from classic to new clinical approaches | Cuadrado, Antonio CSIC ORCID; León, Rafael CSIC ORCID | capítulo de libro |
closedAccess |  | 2017 | Mortality Associated with Bacteremia Due to Colistin-Resistant Klebsiella pneumoniae with High-Level Meropenem Resistance: Importance of Combination Therapy without Colistin and Carbapenems | Machuca, Isabel; Gutiérrez-Gutiérrez, Belén CSIC ORCID; Gracia-Ahufinger, Irene; Rivera-Espinar, Francisco; Cano, Ángela; Guzmán-Puche, Julia; Pérez-Nadales, Elena; Natera, Clara; Rodríguez, Marina; León, Rafael CSIC ORCID ; Castón, Juan J.; Rodríguez-López, Fernando; Rodríguez-Baño, Jesús CSIC ORCID; Torre-Cisneros, Julián | artículo |
openAccess |  | 2018 | Multitarget compounds for the treatment of neurodegenerative diseases: Nrf2-EpRE pathway as key target | Michalska, Patrycja; Buendía Abaitua, Izaskun; Duarte, Pablo; Luengo, Enrique; Fernández-Mendívil, Cristina; Morales-García, José A. CSIC ORCID; Pérez Castillo, Ana CSIC ORCID; García-López, Manuela; León, Rafael CSIC ORCID | comunicación de congreso |
openAccess |  | 17-Jul-2020 | Multitarget Virtual Screening for Drug Repurposing in COVID19 | Sorzano, Carlos Óscar S.; Crisman, Enrique; Carazo, José M.; León, Rafael CSIC ORCID | artículo |
closedAccess | | 2011 | N-Acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer’s disease | González Muñoz, Gema C.; Arce, Mariana P. CSIC; López, Beatriz; López, Beatriz; Romero, Alejandro CSIC ORCID; del Barrio, Laura; Martín de Saavedra, María Dolores; Egea, Javier; León, Rafael CSIC ORCID ; Villarroya, Mercedes; López, Manuela G.; García, Antonio G.; Conde, Santiago CSIC; Rodríguez-Franco, María Isabel CSIC ORCID | artículo |
openAccess |  | 8-Jul-2019 | New neurogenic inducers with combined activities in key targets related to Alzheimer¿s disease | Herrera-Arozamena, Clara; Estrada-Valencia, M.; Pérez, C.; Viña, D.; Michalska, Patrycja; León, Rafael CSIC ORCID ; López, M. G.; Morales-García, J. A.; Perez-Castillo, Amalia; Rodríguez-Franco, María Isabel CSIC ORCID | comunicación de congreso |