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openAccesstubulin_binding_Coderch.pdf.jpgMar-2013A structure-based design of new C2- and C13-substituted taxanes: Tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysisCoderch, Claire; Tang, Yong; Klett, Javier CSIC ORCID; Zhang, Shu-En; Ma, Yung-Tao; Shaorong, Wang; Matesanz, Ruth CSIC ; Pera, Benet CSIC; Canales, Ángeles CSIC ORCID; Jiménez-Barbero, Jesús CSIC ORCID; Morreale, Antonio; Díaz, José Fernando CSIC ORCID ; Fang, Wei-shuo S.; Gago, Federico CSIC ORCIDartículo
closedAccess2007Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studiesLa Regina, Giuseppe; Edler, Michael C.; Brancale, Andrea; Kandil, Sahar; Coluccia, Antonio; Piscitelli, Francesco; Hamel, Ernest; De Martino, Gabriella; Matesanz, Ruth CSIC ; Díaz, José Fernando CSIC ORCID ; Scovassi, Anna Ivana; Prosperi, Ennio; Lavecchia, Antonio; Novellino, Ettore; Artico, Marino; Silvestri, Romanoartículo
openAccesscyclostreptin_Buey.pdf.jpgJan-2007Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sitesMartínez Buey, Rubén CSIC ORCID CVN; Calvo, Enrique; Barasoain, Isabel CSIC ; Pineda, Oriol; Edler, Michael C.; Matesanz, Ruth CSIC ; Cerezo, Gemma; Vanderwal, Christopher D.; Day, Billy W.; Sorensen, Erik J.; López, Juan Antonio; Andreu, José Manuel CSIC ORCID ; Hamel, Ernest; Díaz, José Fernando CSIC ORCID artículo
closedAccessrestringido.pdf.jpgJan-2012Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel SiteCalvo, Enrique; Barasoain, Isabel CSIC ; Matesanz, Ruth CSIC ; Pera, Benet CSIC; Camafeita, Emilio; Pineda, Oriol; Hamel, Ernest; Vanderwal, Christopher D.; Andreu, José Manuel CSIC ORCID ; López, Juan Antonio; Díaz, José Fernando CSIC ORCID artículo
closedAccessrestringido.pdf.jpg5-Oct-2009Epothilone Analogs with Benzimidazole and Quinoline Side Chains: Chemical Synthesis, Antiproliferative Activity, and Interactions with TubulinDietrich, Silvia Anthoine; Lindauer, Renate; Stierling, Claire; Gertsch, Jürg; Matesanz, Ruth CSIC ; Notararigo, Sara CSIC; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinzartículo
openAccessJournal of Biophotonics_Spicer_2022.pdf.jpgFeb-2021Harnessing DNA for nanothermometrySpicer, Graham; Gutierrez-Erlandsson, Sylvia; Matesanz, Ruth CSIC ; Bernard, Hugo; Adam, Alejandro P.; Efeyan, A.; Thompson, Sebastianartículo
closedAccessaccesoRestringido.pdf.jpgMar-2015Identification and characterization of carboxyl esterases of gill chamber-associated microbiota in the deep-sea shrimp Rimicaris exoculata by using functional metagenomicsAlcaide, María CSIC; Tchigvintsev, Anatoli; Martínez-Martínez, Mónica CSIC ORCID; Popovic, Ana; Reva, Oleg; Lafraya Aguado, Álvaro; Bargiela, Rafael CSIC ORCID CVN; Nechitaylo, Taras Y.; Matesanz, Ruth CSIC ; Cambon-Bonavita, M. A.; Jebbar, M.; Yakimov, Michail M.; Savchenko, Alexei; Golyshina, Olga V.; Yakunin, Alexander F.; Golyshin, Peter N.; Ferrer, Manuelartículo
openAccessMatesanz_et_al_2011 Biophysical Journal.pdf.jpg21-Dec-2011Modulation of microtubule interprotofilament interactions by modified taxanesMatesanz, Ruth CSIC ; Rodríguez-Salarichs, Javier; Pera, Benet CSIC; Canales, Ángeles CSIC ORCID; Andreu, José Manuel CSIC ORCID ; Jiménez-Barbero, Jesús CSIC ORCID; Bras, Wim; Nogales, Aurora CSIC ORCID; Fang, Wei-shuo S.; Díaz, José Fernando CSIC ORCID artículo
openAccessMicrob. Cell Fact. _Matesanz_2015.pdf.jpg9-Oct-2015Molecular adaptation of Lactobacillus plantarum WCFS1 to gallic acid revealed by genome‑scale transcriptomic signature and physiological analysisReverón, Inés CSIC; Rivas, Blanca de las CSIC ORCID; Matesanz, Ruth CSIC ; Muñoz, Rosario CSIC ORCID ; López de Felipe, Félix CSIC ORCIDartículo
closedAccessrestringido.pdf.jpg5-Mar-2012Multiple keys for a single lock: the unusual structural plasticity of the Nucleotidyltransferase (4’)/kanamycin complex ChemistryMatesanz, Ruth CSIC ; Díaz, José Fernando CSIC ORCID ; Corzana, Francisco; Santana, Andrés G. CSIC ORCID; Bastida, Agatha CSIC ORCID ; Asensio, Juan Luis CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg16-Jul-2013New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanismPera, Benet CSIC; Barasoain, Isabel CSIC ; Pantazopoulou, Areti CSIC ORCID; Canales, Ángeles CSIC ORCID; Matesanz, Ruth CSIC ; Rodríguez-Salarichs, Javier; García-Fernández, Luis F. CSIC; Moneo, Victoria; Jiménez-Barbero, Jesús CSIC ORCID; Galmarini, Carlos M.; Cuevas, Carmen; Peñalva, Miguel Ángel CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Andreu, José Manuel CSIC ORCID artículo
openAccessMatesanz-Ruth.pdf.jpg2009Optimización de la interacción microtúbulo-taxol: Diseño de taxanos de alta afinidadMatesanz, Ruth CSIC tesis doctoral
closedAccessMatesanz et al-2008_Chemistry and Biology.pdf.jpg23-Jun-2008Optimization of Taxane Binding to Microtubules: Binding Affinity Dissection and Incremental Construction of a High-Affinity Analog of PaclitaxelMatesanz, Ruth CSIC ; Barasoain, Isabel CSIC ; Yang, Chun-Gang; Wan, L.; Li, Xuan; Inés, Concepción de; Coderch, Claire; Gago, Federico CSIC ORCID; Jiménez-Barbero, Jesús CSIC ORCID; Andreu, José Manuel CSIC ORCID ; Fang, Wei-shuo S.; Díaz, José Fernando CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg14-May-2007Overcoming tumor drug resistance with high-affinity taxanes: A SAR study of C2-modified 7-acyl-10-deacetyl cephalomanninesYang, Chun-Gang; Barasoain, Isabel CSIC ; Li, Xuan; Matesanz, Ruth CSIC ; Liu, Ronghua; Sharom, Frances J.; Yin, Da-Li; Díaz, José Fernando CSIC ORCID ; Fang, Wei-shuo S.artículo
closedAccessaccesoRestringido.pdf.jpg26-Mar-2010Probing the Pore Drug Binding Site of Microtubules with Fluorescent Taxanes: Evidence of Two Binding PosesBarasoain, Isabel CSIC ; García-Carril, Ana M.; Matesanz, Ruth CSIC ; Maccari, Giorgio; Trigili, Chiara CSIC; Mori, Mattia; Shi, Jing-Zhe; Fang, Wei-shuo S.; Andreu, José Manuel CSIC ORCID ; Botta, Maurizio; Díaz, José Fernando CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg1-Feb-2009Synthesis and biological activities of high affinity taxane-based fluorescent probesLi, Xuan; Barasoain, Isabel CSIC ; Matesanz, Ruth CSIC ; Díaz, José Fernando CSIC ORCID ; Fang, Wei-shuo S.artículo
closedAccessaccesoRestringido.pdf.jpg1-Jun-2007Synthesis, biological evaluations, and tubulin binding poses of C-2α sulfur linked taxol analoguesWang, Lei; Alcaraz, Ana A.; Matesanz, Ruth CSIC ; Yang, Chun-Gang; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID ; Li, Ye-Zhi; Snyder, James P.; Fang, Wei-shuo S.artículo
openAccessmolecules-2016.pdf.jpg3-Aug-2016Synthesis, biological profiling and determination of the tubulin-bound conformation of 12-Aza-epothilones (azathilones)Jantsch, Andrea; Nieto, Lidia CSIC; Gertsch, Jürg; Rodríguez-Salarichs, Javier; Matesanz, Ruth CSIC ; Jiménez-Barbero, Jesús CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Canales, Ángeles CSIC ORCID; Altmann, Karl-Heinzartículo
openAccessmolecules-21-01010.pdf.jpg3-Aug-2016Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones)Jantsch, Andrea; Nieto, Lidia CSIC; Gertsch, Jürg; Rodríguez-Salarichs, Javier; Matesanz, Ruth CSIC ; Jiménez-Barbero, Jesús CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Canales, Ángeles CSIC ORCID; Altmann, Karl-Heinzartículo
openAccessMatesanz et al_2014 _Bioorganic Medicinal Chemistry.pdf.jpg19-Jun-2014Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistancesMatesanz, Ruth CSIC ; Trigili, Chiara CSIC; Rodríguez-Salarichs, Javier; Pera, Benet CSIC; Jiménez-Barbero, Jesús CSIC ORCID; Canales, Ángeles CSIC ORCID; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID artículo