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openAccessNature Communications_Menchon_2018.pdf.jpg29-May-2018A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulinMenchon, Grégory; Lucena-Agell, Daniel CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Steinmetz, Michel O.artículo
closedAccessaccesoRestringido.pdf.jpg12-Oct-2020A method for the stereoselective construction of the hemiaminal center in zampanolidesBrütsch, Tobias M.; Berardozzi, Simone; Rothe, Marlene L.; Redondo-Horcajo, Mariano CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Altmann, Karl-Heinzartículo
openAccesstubulin_binding_Coderch.pdf.jpgMar-2013A structure-based design of new C2- and C13-substituted taxanes: Tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysisCoderch, Claire; Tang, Yong; Klett, Javier CSIC ORCID; Zhang, Shu-En; Ma, Yung-Tao; Shaorong, Wang; Matesanz, Ruth CSIC ; Pera, Benet CSIC; Canales, Ángeles CSIC ORCID; Jiménez-Barbero, Jesús CSIC ORCID; Morreale, Antonio; Díaz, José Fernando CSIC ORCID ; Fang, Wei-shuo S.; Gago, Federico CSIC ORCIDartículo
openAccessJ. Biol. Chem.-2001-D__az-17307-15.pdf.jpg18-May-2001Activation of cell division protein FtsZ. Control of switch loop T3 conformation by the nucleotide gamma-phosphateDíaz, José Fernando CSIC ORCID ; Kralicek, Andrew; Mingorance, Jesús; Palacios, Juan Manuel; Vicente, Miguel; Andreu, José Manuel CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg26-Aug-2016Aggregated compound biological signatures facilitate phenotypic drug discovery and target elucidationCortés Cabrera, Álvaro CSIC ORCID; Lucena-Agell, Daniel CSIC ORCID ; Redondo-Horcajo, Mariano CSIC ORCID ; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID ; Fasching, Bernhard; Petrone, Paula M.artículo
openAccessOncotarget.pdf.jpg20-May-2016Antivascular and antitumor properties of the tubulin-binding chalcone TUB091Canela, María-Dolores CSIC; Noppen, Sam; Bueno, Oskía; Prota, Andrea E.; Bargsten, Katja; Sáez-Calvo, Gonzalo; Jimeno, M. Luisa CSIC ORCID; Benkhei, Mohammed; Ribatti, Domenico; Velázquez, Sonsoles CSIC ORCID CVN; Camarasa Rius, María José CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Steinmetz, Michel O.; Priego, Eva María CSIC ORCID; Peréz-Pérez, María-Jesús CSIC ORCID ; Liekens, Sandraartículo
closedAccessrestringido.pdf.jpgJul-2008Apo-Hsp90 coexists in two open conformational states in solutionBron, P.; Giudice, E.; Rolland, J.P.; Martínez Buey, Rubén CSIC ORCID CVN; Barbier, Pascale; Díaz, José Fernando CSIC ORCID ; Peyrot, Vincent; Thomas, D.; Garnier, C.artículo
closedAccess2007Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studiesLa Regina, Giuseppe; Edler, Michael C.; Brancale, Andrea; Kandil, Sahar; Coluccia, Antonio; Piscitelli, Francesco; Hamel, Ernest; De Martino, Gabriella; Matesanz, Ruth CSIC ; Díaz, José Fernando CSIC ORCID ; Scovassi, Anna Ivana; Prosperi, Ennio; Lavecchia, Antonio; Novellino, Ettore; Artico, Marino; Silvestri, Romanoartículo
openAccessJ. Biol. Chem.-1998-D__az-33803-10.pdf.jpg11-Dec-1998Changes in microtubule protofilament number induced by Taxol binding to an easily accessible site. Internal microtubule dynamicsDíaz, José Fernando CSIC ORCID ; Valpuesta, José M. CSIC ORCID ; Chacón, Pablo CSIC ORCID; Diakun, Gregory P.; Andreu, José Manuel CSIC ORCID artículo
closedAccess2007Characterizing Ligand-Microtubule binding by competition methodsDíaz, José Fernando CSIC ORCID ; Martínez Buey, Rubén CSIC ORCID CVNartículo
openAccessCHLOROACETYLATION OF CYCLOSTREPTIN INFLUENCES.pdf.jpg2009Chloroacetylation of cyclostreptin influences its interaction with tubulinCalvo, Enrique; Barasoain, Isabel CSIC ; Camafeita, Emilio; Andreu, José Manuel CSIC ORCID ; López, Juan Antonio; Díaz, José Fernando CSIC ORCID comunicación de congreso
closedAccessaccesoRestringido.pdf.jpg2012Comparative Binding Energy (COMBINE) Analysis Supports a Proposal for the Binding Mode of Epothilones to β-TubulinCoderch, Claire; Klett, Javier CSIC ORCID; Morreale, Antonio; Díaz, José Fernando CSIC ORCID ; Gago, Federico CSIC ORCIDartículo
openAccessaccesoRestringido.pdf.jpg2018Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activityBueno, Oskía; Tobajas, Gloria; Quesada, Ernesto; Estévez-Gallego, Juan CSIC ORCID ; Noppen, Sam; Camarasa Rius, María José CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Liekens, Sandra; Priego, Eva María CSIC ORCID; Peréz-Pérez, María-Jesús CSIC ORCID artículo
openAccessJ. Biol. Chem.-1998-Menéndez-167-76.pdf.jpg2-Jan-1998Control of the structural stability of the tubulin dimer by one high affinity bound magnesium ion at nucleotide N-siteMenéndez, Margarita CSIC ORCID; Rivas, Germán CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Andreu, José Manuel CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg14-Jun-2011Corrigendum: Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and JTrigili, Chiara CSIC; Pera, Benet CSIC; Barbazanges, Marion; Cossy, Janine; Meyer, Christophe; Pineda, Oriol; Rodríguez-Escrich, Carles; Urpí, Félix; Vilarrasa, Jaume; Díaz, José Fernando CSIC ORCID ; Barasoain, Isabel CSIC corrigenda
openAccessJ. Biol. Chem.-2010-Bustamante-33184-96.pdf.jpg22-Oct-2010Cpl-7, a Lysozyme Encoded by a Pneumococcal Bacteriophage with a Novel Cell Wall-Binding MotifBustamante, Noemí CSIC; Campillo, Nuria E. CSIC ORCID ; García, Ernesto CSIC ORCID ; Gallego, Cristina; Pera, Benet CSIC; Diakun, Gregory P.; Saiz, José L.; García, Pedro CSIC ORCID ; Díaz, José Fernando CSIC ORCID ; Menéndez, Margarita CSIC ORCIDartículo
openAccessijms-20-01392.pdf.jpg20-Mar-2019Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site LigandsBalaguer, Francisco de Asís; Mühlethaler, Tobias; Estévez-Gallego, Juan CSIC ORCID ; Calvo, Enrique; Giménez-Abián, Juan F. CSIC ; Risinger, April L.; Sorensen, Erik J.; Vanderwal, Christopher D.; Altmann, Karl-Heinz; Mooberry, Susan; Steinmetz, Michel O.; Oliva, María A. CSIC ORCID ; Prota, Andrea E.; Díaz, José Fernando CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg30-Aug-2005Cyclostreptin (FR182877), an Antitumour Tubulin-Polymerizing Agent Deficient in Enhancing Tubulin Assembly Despite Its High Affinity for the Taxoid SiteEdler, Michael C.; Martínez Buey, Rubén CSIC ORCID CVN; Gussio, Rick; Marcus, Adam I.; Vanderwal, Christopher D.; Sorensen, Erik J.; Díaz, José Fernando CSIC ORCID ; Giannakakou, Paraskevi; Hamel, Ernestartículo
openAccesscyclostreptin_Buey.pdf.jpgJan-2007Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sitesMartínez Buey, Rubén CSIC ORCID CVN; Calvo, Enrique; Barasoain, Isabel CSIC ; Pineda, Oriol; Edler, Michael C.; Matesanz, Ruth CSIC ; Cerezo, Gemma; Vanderwal, Christopher D.; Day, Billy W.; Sorensen, Erik J.; López, Juan Antonio; Andreu, José Manuel CSIC ORCID ; Hamel, Ernest; Díaz, José Fernando CSIC ORCID artículo
closedAccessrestringido.pdf.jpgJan-2012Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel SiteCalvo, Enrique; Barasoain, Isabel CSIC ; Matesanz, Ruth CSIC ; Pera, Benet CSIC; Camafeita, Emilio; Pineda, Oriol; Hamel, Ernest; Vanderwal, Christopher D.; Andreu, José Manuel CSIC ORCID ; López, Juan Antonio; Díaz, José Fernando CSIC ORCID artículo