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openAccessNature Communications_Menchon_2018.pdf.jpg29-May-2018A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulinMenchon, Grégory; Lucena-Agell, Daniel ; Díaz, José Fernando  ; Steinmetz, Michel O.artículo
openAccesstubulin_binding_Coderch.pdf.jpgMar-2013A structure-based design of new C2- and C13-substituted taxanes: Tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysisCoderch, Claire; Tang, Yong; Klett, Javier ; Zhang, Shu-En; Ma, Yung-Tao; Shaorong, Wang; Matesanz, Ruth  ; Pera, Benet ; Canales, Ángeles ; Jiménez-Barbero, Jesús ; Morreale, Antonio ; Díaz, José Fernando  ; Fang, Wei-shuo S.; Gago, Federico artículo
openAccessJ. Biol. Chem.-2001-D__az-17307-15.pdf.jpg18-May-2001Activation of cell division protein FtsZ. Control of switch loop T3 conformation by the nucleotide gamma-phosphateDíaz, José Fernando  ; Kralicek, Andrew; Mingorance, Jesús; Palacios, Juan Manuel; Vicente, Miguel; Andreu, José Manuel  artículo
openAccessOncotarget.pdf.jpg20-May-2016Antivascular and antitumor properties of the tubulin-binding chalcone TUB091Canela, María-Dolores ; Noppen, Sam; Bueno, Oskía; Prota, Andrea E.; Bargsten, Katja; Sáez-Calvo, Gonzalo; Jimeno, M. Luisa ; Benkhei, Mohammed; Ribatti, Domenico; Velázquez, Sonsoles ; Camarasa Rius, María José ; Díaz, José Fernando  ; Steinmetz, Michel O.; Priego, Eva María ; Peréz-Pérez, María-Jesús  ; Liekens, Sandraartículo
closedAccessrestringido.pdf.jpgJul-2008Apo-Hsp90 coexists in two open conformational states in solutionBron, P.; Giudice, E.; Rolland, J.P.; Martínez Buey, Rubén ; Barbier, Pascale; Díaz, José Fernando  ; Peyrot, Vincent; Thomas, D.; Garnier, C.artículo
closedAccess2007Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studiesLa Regina, Giuseppe; Edler, Michael C.; Brancale, Andrea; Kandil, Sahar; Coluccia, Antonio; Piscitelli, Francesco; Hamel, Ernest; De Martino, Gabriella; Matesanz, Ruth  ; Díaz, José Fernando  ; Scovassi, Anna Ivana; Prosperi, Ennio; Lavecchia, Antonio; Novellino, Ettore; Artico, Marino; Silvestri, Romanoartículo
openAccessJ. Biol. Chem.-1998-D__az-33803-10.pdf.jpg11-Dec-1998Changes in microtubule protofilament number induced by Taxol binding to an easily accessible site. Internal microtubule dynamicsDíaz, José Fernando  ; Valpuesta, José M. ; Chacón, Pablo ; Diakun, Gregory P.; Andreu, José Manuel  artículo
closedAccess2007Characterizing Ligand-Microtubule binding by competition methodsDíaz, José Fernando  ; Martínez Buey, Rubén artículo
closedAccessaccesoRestringido.pdf.jpg2012Comparative Binding Energy (COMBINE) Analysis Supports a Proposal for the Binding Mode of Epothilones to β-TubulinCoderch, Claire; Klett, Javier ; Morreale, Antonio ; Díaz, José Fernando  ; Gago, Federico artículo
openAccessaccesoRestringido.pdf.jpg2018Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activityBueno, Oskía; Tobajas, Gloria; Quesada, Ernesto; Estévez-Gallego, Juan ; Noppen, Sam; Camarasa Rius, María José ; Díaz, José Fernando  ; Liekens, Sandra; Priego, Eva María ; Peréz-Pérez, María-Jesús  artículo
openAccessJ. Biol. Chem.-1998-Menéndez-167-76.pdf.jpg2-Jan-1998Control of the structural stability of the tubulin dimer by one high affinity bound magnesium ion at nucleotide N-siteMenéndez, Margarita ; Rivas, Germán  ; Díaz, José Fernando  ; Andreu, José Manuel  artículo
openAccessJ. Biol. Chem.-2010-Bustamante-33184-96.pdf.jpg22-Oct-2010Cpl-7, a Lysozyme Encoded by a Pneumococcal Bacteriophage with a Novel Cell Wall-Binding MotifBustamante, Noemí ; Campillo, Nuria E.  ; García, Ernesto  ; Gallego, Cristina; Pera, Benet ; Diakun, Gregory P.; Saiz, José L.; García, Pedro  ; Díaz, José Fernando  ; Menéndez, Margarita artículo
ijms-20-01392.pdf.jpg20-Mar-2019Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site LigandsBalaguer, Francisco de Asís; Mühlethaler, Tobias; Estévez-Gallego, Juan ; Calvo, Enrique; Giménez-Abián, Juan F.  ; Risinger, April L.; Sorensen, Erik J.; Vanderwal, Christopher D.; Altmann, Karl-Heinz; Mooberry, Susan; Steinmetz, Michel O.; Oliva, María A. ; Prota, Andrea E.; Díaz, José Fernando  artículo
closedAccessaccesoRestringido.pdf.jpg30-Aug-2005Cyclostreptin (FR182877), an Antitumour Tubulin-Polymerizing Agent Deficient in Enhancing Tubulin Assembly Despite Its High Affinity for the Taxoid SiteEdler, Michael C.; Buey, Ruben M.; Gussio, Rick; Marcus, Adam I.; Vanderwal, Christopher D.; Sorensen, Erik J.; Díaz, José Fernando  ; Giannakakou, Paraskevi; Hamel, Ernestartículo
openAccesscyclostreptin_Buey.pdf.jpgJan-2007Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sitesBuey, Ruben M.; Calvo, Enrique; Barasoain, Isabel ; Pineda, Oriol; Edler, Michael C.; Matesanz, Ruth  ; Cerezo, Gemma; Vanderwal, Christopher D.; Day, Billy W.; Sorensen, Erik J.; López, Juan Antonio; Andreu, José Manuel  ; Hamel, Ernest; Díaz, José Fernando  artículo
closedAccessrestringido.pdf.jpgJan-2012Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel SiteCalvo, Enrique; Barasoain, Isabel ; Matesanz, Ruth  ; Pera, Benet ; Camafeita, Emilio; Pineda, Oriol; Hamel, Ernest; Vanderwal, Christopher D.; Andreu, José Manuel  ; López, Juan Antonio; Díaz, José Fernando  artículo
openAccessEBCAM_2015.pdf.jpg2015Cytotoxic activity and chemical composition of the root extract from the mexican species Linum scabrellum: mechanism of action of the active compound 6-MethoxypodophyllotoxinAlejandre-García, Ivonne; Álvarez, Laura ; Cardoso-Taketa, Alexandre; González-Maya, Leticia; Antúnez, Mayra; Salas-Vidal, Enrique; Díaz, José Fernando  ; Marquina-Bahena, Silvia; Villarreal, María Luisaartículo
openAccessncomms 2017.pdf.jpg9-Mar-2017Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic interventionBohnacker, Thomas; Díaz, José Fernando  ; Wymann, Matthias P.artículo
closedAccessMay-2011Design and Synthesis of Pironetin Analogues with Simplified Structure and Study of Their Interactions with MicrotubulesMarco, J. Alberto; García-Plab, Jorge; Carda, Miguel; Murga, Juan; Falomir, Eva; Trigili, Chiara ; Notararigo, Sara ; Díaz, José Fernando  ; Barasoain, Isabel artículo
closedAccessEJMC_Diphenyl_ether_derivatives_2019.pdf.jpgJun-2019Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the aT5 loopBueno, Oskia; Gargantilla, Marta; Estévez-Gallego, Juan ; Martins, Solange; Díaz, José Fernando  ; Camarasa Rius, María José ; Liekens, Sandra; Peréz-Pérez, María-Jesús  ; Priego, Eva María artículo