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Title

Direct mass spectrometry-based approaches in metabolomics

AuthorsIbáñez, Clara ; García-Cañas, Virginia ; Valdés, Alberto ; Simó, Carolina
KeywordsDESI
SIMS
MALDI
Ambient MS
DART
Imaging MS
NIMS
Mass spectrometry
Issue Date2014
PublisherElsevier
CitationComprehensive Analytical Chemistry 63(Chap.10): 235-253 (2014)
AbstractMetabolomics is one of the newest Omics technologies concerned with the identification and quantification of small molecules in a high-throughput manner. Considering the number of different types of metabolites present in a wide dynamic range of concentrations in any single living system, actual analytical technologies can still only capture a part of the metabolome. Currently, MS-based approaches yield a higher sensitivity than NMR when analyzing minimal amounts of complex mixtures. Most MS-based approaches in metabolomics involve a physical/chemical purification/fractionation prior to MS analysis, to avoid sample matrix effects, at the expense of low high-throughput performance. In the quest to achieve the maximum high-throughput production of metabolite information in the largest possible number of samples, an extensive array of direct ionization or desorption/ionization techniques have been developed and combined. In the this chapter, an overview of the main desorption/ionization techniques coupled with MS applied to direct metabolite profiling or fingerprinting is presented. © 2014 Elsevier B.V.
Publisher version (URL)http://dx.doi.org/10.1016/B978-0-444-62651-6.00010-6
URIhttp://hdl.handle.net/10261/99917
DOI10.1016/B978-0-444-62651-6.00010-6
Identifiersdoi: 10.1016/B978-0-444-62651-6.00010-6
isbn: 978-0-444-62650-9
Appears in Collections:(CIAL) Libros y partes de libros
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