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Título

Comparative study of microbial-derived phenolic metabolites in human feces after intake of gin, red wine, and dealcoholized red wine

AutorJiménez-Girón, Ana; Queipo-Ortuño, María Isabel; Muñoz-González, Irene CSIC ORCID; Sánchez-Patán, Fernando CSIC; Monagas Juan, María Josefina CSIC; Martín-Álvarez, Pedro J. CSIC ORCID; Tinahones, Francisco J.; Andrés-Lacueva, Cristina; Bartolomé, Begoña CSIC ORCID ; Moreno-Arribas, M. Victoria CSIC ORCID
Palabras claveFeces
UPLC-ESI-MS/MS
Microbial metabolites
Gut microbiota
Red wine polyphenols
Fecha de publicación2013
EditorAmerican Chemical Society
CitaciónJournal of Agricultural and Food Chemistry 61(16): 3909-3915 (2013)
ResumenThe analysis of microbial phenolic metabolites in fecal samples from in vivo studies is crucial to understanding the potential modulatory effects derived from polyphenol consumption and its overall health effects, particularly at the gut level. In this study, the composition of microbial phenolic metabolites in human feces collected after regular consumption of either red wine, dealcoholized red wine, or gin was analyzed by UPLC-ESI-MS/MS. Red wine interventions produce a change in the content of eight phenolic acids, which are probably derived from the catabolism of flavan-3-ols and anthocyanins, the main flavonoids in red wine. Moreover, alcohol seemed not to influence the formation of phenolic metabolites by the gut microbiota. A principal component analysis revealed large interindividual differences in the formation of microbial metabolites after each red wine polyphenol intervention, but not after the gin intervention, indicating differences in the gut microbial composition among subjects. © 2013 American Chemical Society.
URIhttp://hdl.handle.net/10261/99896
DOI10.1021/jf400678d
Identificadoresdoi: 10.1021/jf400678d
issn: 0021-8561
e-issn: 1520-5118
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