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Title

Modeling structural and genomic constraints in the evolution of proteins

AuthorsBastolla, Ugo
Issue Date2012
PublisherSpringer
CitationComputational modeling of biological systems: 327- 346 (2012)
AbstractMacromolecules influence the phenotype of the organism where they are expressed through their function, and in particular through their interactions. Nevertheless, it is very difficult to computationally predict protein function and interactions. Moreover, only a few residues take part in them. For these reasons, models of molecular evolution usually represent folded macromolecules such as RNA or proteins and identify the function of the molecule with the folded structure, whose stability determines the modeled fitness.
URIhttp://hdl.handle.net/10261/99864
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