English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/99815
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Bioavailability of antihypertensive lactoferricin B-derived peptides: Transepithelial transport and resistance to intestinal and plasma peptidases

AuthorsFernández-Musoles, Ricardo ; Salom, Juan B.; Castelló-Ruiz, María; Contreras, María del Mar; Recio, Isidra ; Manzanares, Paloma
Issue Date2013
PublisherElsevier
CitationInternational Dairy Journal 32(2): 169-174 (2013)
AbstractThe transepithelial transport of the angiotensin I-converting enzyme (ACE)-inhibitory and antihypertensive lactoferricin B (LfcinB)-derived hexapeptide LfcinB20-25 (RRWQWR) and of its two main fragments RWQ and WQ were investigated using a human intestinal cell (Caco-2) monolayer. The three peptides were susceptible to the action of brush-border peptidases. Intact LfcinB20-25 was not transported across Caco-2 whereas RWQ and WQ were both absorbed through the cell monolayer. Apparent permeability (Papp) values for absorptive transport across the monolayer were 0.7×10-8cms-1 (RWQ) and 3.9×10-8cms-1 (WQ). The effect of pathway-selective inhibitors on peptide absorption suggested paracellular diffusion as the main mechanism for the transport of intact RWQ and WQ. Invitro incubation in human plasma showed half-life values of 1.9min (RWQ) and 2.3h (WQ). These results highlight the possibility of transport of antihypertensive lactoferricin B-derived peptides across human intestinal mucosa. © 2013 Elsevier Ltd.
URIhttp://hdl.handle.net/10261/99815
DOI10.1016/j.idairyj.2013.05.009
Identifiersdoi: 10.1016/j.idairyj.2013.05.009
issn: 0958-6946
e-issn: 1879-0143
Appears in Collections:(IATA) Artículos
(CIAL) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.