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dc.contributor.authorGarcía-López, Jesús-
dc.contributor.authorHourcade, Juan D.-
dc.contributor.authorAlonso, Lola-
dc.contributor.authorCárdenas, David B.-
dc.contributor.authorDel Mazo, Jesús-
dc.date.accessioned2014-07-10T08:29:25Z-
dc.date.available2014-07-10T08:29:25Z-
dc.date.issued2014-06-
dc.identifier.citationBiochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2014,1839 ( 6) 463–475es_ES
dc.identifier.issn1874-9399-
dc.identifier.urihttp://hdl.handle.net/10261/99664-
dc.description44 p.-1 tab.-10 fig.es_ES
dc.description.abstractA set of small RNAs known as rasRNAs (repeat-associated small RNAs) have been related to the down-regulation of Transposable Elements (TEs) to safeguard genome integrity. Two key members of the rasRNAs group are piRNAs and endo-siRNAs. We have performed a comparative analysis of piRNAs and endo-siRNAs present in mouse oocytes, spermatozoa and zygotes, identified by deep sequencing and bioinformatic analysis. The detection of piRNAs and endo-siRNAs in the spermatozoa and revealed also in zygotes, hints to their potential delivery to oocytes during fertilization. However, a comparative assessment of the three cell types indicates that both piRNAs and endo-siRNAs are mainly maternally inherited. Finally, we have assessed the role of the different rasRNA molecules in connection with amplification processes by way of the "ping-pong cycle". Our results suggest that the ping-pong cycle can act on other rasRNAs, such as tRNA- and rRNA-derived fragments, thus not only being restricted to TEs during gametogenesis. © 2014 Elsevier B.V.es_ES
dc.description.sponsorshipThis work was funded by grants from The European Chemical Industry Council Long-range Research Initiative (CEFIC-LRi), from the MEDDTL (11-MRESPNRPE-9-CVS-072), France, from the CSIC (PIE 201020E016), Spain.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rightsopenAccesses_ES
dc.subjectPiRNAses_ES
dc.subjectEndo-siRNAses_ES
dc.subjectDeep sequencinges_ES
dc.subjectTransposable elementses_ES
dc.subjectGerm cellses_ES
dc.subjectZygotees_ES
dc.titleGlobal characterization and target identification of piRNAs and endo-siRNAs in mouse gametes and zygoteses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.bbagrm.2014.04.006-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.bbagrm.2014.04.006es_ES
dc.embargo.terms2015-06es_ES
dc.relation.csices_ES
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