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Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-cyclodextrin heterodimers

AuthorsGallego-Yerga, Laura; Lomazzi, Michela; Sansone, Francesco; Ortiz-Mellet, Carmen; Casnati, Alessandro; García-Fernández, José Manuel
Issue Date2014
PublisherRoyal Society of Chemistry (UK)
CitationChemical Communications, 50: 7440-7443 (2014)
AbstractStable core–shell nanospheres self-assemble in water from heterodimers combining a hydrophobic calix[4]arene moiety and a hydrophilic β-cyclodextrin head; their potential to encapsulate and provide sustained release of the anticancer drug docetaxel and undergo surface post-modification with glycoligands targeting the macrophage mannose receptor is discussed.
Publisher version (URL)http://dx.doi.org/10.1039/c0xx00000x
Appears in Collections:(IIQ) Artículos
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