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dc.contributor.authorGarcía-López, Jesús-
dc.contributor.authorHourcade, Juan D.-
dc.contributor.authorDel Mazo, Jesús-
dc.identifier.citationNucleic Acids Research, 2013,41 (10) 5483–5493es_ES
dc.description11 p.-5 fig.es_ES
dc.description.abstractAdenosine deaminases-acting-on-RNA (ADAR) proteins induce adenosine-to-inosine editing in double-stranded RNA molecules. This editing generates RNA diversity at the post-transcriptional level, and it has been implicated in the control of cell differentiation and development. The editing of microRNA (miRNA) precursors, along with Tudor-SN (Snd1) activity, could lead to the elimination of selected miRNAs and reprogram miRNA activity.Here, we report the dynamics of adenosine-toinosine editing in miRNA precursors and their selected elimination during mouse preimplantation development. Adar1p110 and Snd1 were found to be strongly but differentially expressed in oocytes and zygotes with respect to later pre-implantation stages. When the biogenesis of miR-151 was assessed, the majority of miR-151 precursors was edited and subsequently eliminated during early development. Deep sequencing of this and other miRNAs confirmed that, in general, edited precursors were selectively eliminated at early post-zygotic stages. Moreover, in oocytes and throughout the zygote-to-blastocyst stages,Tudor-SN accumulated in newly discovered aggregates termed ‘T bodies’. These results provide new insight into how editing and Tudor SN-mediated elimination of miRNA precursors is regulated during early development.es_ES
dc.description.sponsorshipEuropean Chemical Industry Council Long-range Research Initiative (CEFIC-LRi); MEDDTL, France[11-MRES-PNRPE-9-CVS-072]; CSIC, Spain [PIE 201020E016]. Funding for open access charge:MEDDTL, France [11-MRES-PNRPE-9-CVS-072];CSIC, Spain [PIE 201020E016].es_ES
dc.publisherOxford University Presses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.titleReprogramming of microRNAs by adenosine-toinosine editing and the selective elimination of edited microRNA precursors in mouse oocytes and preimplantation embryoses_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.rights.licensehttp://creativecommons.org/licenses/ by-nc/3.0/es_ES
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