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dc.contributor.authorAbenza, J. F.-
dc.contributor.authorGalindo, Antonio-
dc.contributor.authorPinar, Mario-
dc.contributor.authorPantazopoulou, Areti-
dc.contributor.authorde los Ríos, Vivian-
dc.contributor.authorPeñalva, Miguel Ángel-
dc.identifier.citationMol Biol Cell. May 15, 2012; 23(10): 1889–1901es_ES
dc.description13 p.-11 fig.es_ES
dc.description.abstractWe exploit the ease with which highly motile early endosomes are distinguished from static late endosomes in order to study Aspergillus nidulans endosomal traffic. RabSRab7 mediates homotypic fusion of late endosomes/vacuoles in a homotypic fusion- and vacuole protein sorting/Vps41–dependent manner. Progression across the endocytic pathway involves endosomal maturation because the end products of the pathway in the absence of RabSRab7 are minivacuoles that are competent in multivesicular body sorting and cargo degradation but retain early endosomal features, such as the ability to undergo long-distance movement and propensity to accumulate in the tip region if dynein function is impaired. Without RabSRab7, early endosomal Rab5s—RabA and RabB—reach minivacuoles, in agreement with the view that Rab7 homologues facilitate the release of Rab5 homologues from endosomes. RabSRab7 is recruited to membranes already at the stage of late endosomes still lacking vacuolar morphology, but the transition between early and late endosomes is sharp, as only in a minor proportion of examples are RabA/RabB and RabSRab7 detectable in the same—frequently the less motile—structures. This early-to-late endosome/vacuole transition is coupled to dynein-dependent movement away from the tip, resembling the periphery-to-center traffic of endosomes accompanying mammalian cell endosomal maturation. Genetic studies establish that endosomal maturation is essential, whereas homotypic vacuolar fusion is notes_ES
dc.description.sponsorshipThis work was supported by the Spanish government through Dirección General de Investigación Científica y Técnica Grant BIO2009-7281 and by Comunidad de Madrid Networking Grant SAL/0246/2006 to M.A.P.es_ES
dc.publisherAmerican Society for Cell Biologyes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.titleEndosomal maturation by Rab conversion in Aspergillus nidulans is coupled to dynein-mediated basipetal movementes_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.rights.licensehttp://creativecommons.org/licenses/by-ncsa/ 3.0es_ES
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