Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/98824
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Efficient and safe internalization of magnetic iron oxide nanoparticles: Two fundamental requirements for biomedical applications

AutorGutiérrez, Lucía CSIC ORCID; Salas, Gorka; Luengo, Yurena; Morales, M. P. CSIC ORCID ; Miranda, Rodolfo CSIC ORCID; Villanueva, Ángeles
Palabras claveCellular uptake
Cytoxicity
Cytoskeleton
HeLa cell line
Iron oxide magnetic nanoparticles
Fecha de publicación2014
EditorElsevier
CitaciónNanomedicine: Nanotechnology, Biology, and Medicine 10(4): 733-743 (2014)
ResumenWe have performed a series of in vitro tests proposed for the reliable assessment of safety associated with nanoparticles-cell interaction. A thorough analysis of toxicity of three different coating iron oxide nanoparticles on HeLa cells has been carried out including, methyl thiazol tetrazolium bromide (MTT) and Trypan blue exclusion tests, cell morphology observation by optical and Scanning Electron Microscopy (SEM), study of cytoskeletal components, analysis of cell cycle and the presence of reactive oxygen species (ROS). We have quantified magnetic nanoparticle internalization, determined possible indirect cell damages and related it to the nanoparticle coating. The results confirm a very low toxicity of the analyzed iron oxide nanoparticles into HeLa cells by multiple assays and pave the way for a more successful cancer diagnostic and treatment without secondary effects. From the Clinical Editor: In this paper, three different iron oxide nanoparticles are studied and compared from the standpoint of safety and toxicity in HeLa cells, demonstrating low toxicity for each preparation, and paving the way to potential future clinical applications. © 2014 Elsevier Inc.
URIhttp://hdl.handle.net/10261/98824
DOI10.1016/j.nano.2013.11.010
Identificadoresdoi: 10.1016/j.nano.2013.11.010
issn: 1549-9642
Aparece en las colecciones: (ICMM) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

105
checked on 14-mar-2024

WEB OF SCIENCETM
Citations

94
checked on 07-feb-2024

Page view(s)

308
checked on 18-mar-2024

Download(s)

141
checked on 18-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.